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anti-CCNH antibody :: Mouse anti-Human CCNH Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120469
Quality Control
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCNH, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human CCNH

 Product Synonym Names    Homo sapiens cyclin H (CCNH), mRNA.; CAK; p34; p37
 Product Gene Name   

anti-CCNH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601953
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2125C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-CCNH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CCNH antibody

   The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. [provided by RefSeq][NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-CCNH antibody   

Dot Blot (DB)

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 Quality Control of anti-CCNH antibody    Left: Western blot analysis of immunized recombinant protein, using anti-CCNH monoclonal antibody.
anti-CCNH antibody Quality Control image
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NCBI/Uniprot data below describe general gene information for CCNH. It may not necessarily be applicable to this product.
 NCBI GI #    312596942
 NCBI GeneID    902
 NCBI Accession #    NP_001230.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001239 [Other Products]
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 UniProt Secondary Accession #    Q53X72; Q8TBL9 [Other Products]
 UniProt Related Accession #    P51946 [Other Products]
 Molecular Weight    37,643 Da
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 NCBI Official Full Name    Homo sapiens cyclin H (CCNH), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    cyclin H
 NCBI Official Symbol    CCNH [Similar Products]
 NCBI Official Synonym Symbols   
CAK; p34; p37; CycH
[Similar Products]
 NCBI Protein Information    cyclin-H; CAK complex subunit; CDK-activating kinase complex subunit; MO15-associated protein; cyclin-dependent kinase-activating kinase complex subunit
 UniProt Protein Name    Cyclin-H
 UniProt Synonym Protein Names   
MO15-associated protein; p34; p37
 Protein Family    Cyclin
 UniProt Gene Name    CCNH [Similar Products]
 UniProt Entry Name    CCNH_HUMAN
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 NCBI Summary for CCNH    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]
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 UniProt Comments for CCNH    CCNH: Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Belongs to the cyclin family. Cyclin C subfamily.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q13.3-q14

Cellular Component: nucleoplasm; holo TFIIH complex; nucleus; cyclin-dependent protein kinase activating kinase holoenzyme complex

Molecular Function: RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; cyclin-dependent protein kinase regulator activity; protein kinase binding

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; protein amino acid phosphorylation; regulation of gene expression, epigenetic; mRNA capping; nucleotide-excision repair; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleotide-excision repair, DNA damage removal; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; transcription initiation from RNA polymerase I promoter; G1/S transition of mitotic cell cycle
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 Research Articles on CCNH    1. Hemodynamic forces modulate EC proliferative phenotype through the miR-23b/CAK/cyclin H pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCNH antibodyPathways associated with anti-CCNH antibody
 Reference Product  PubMed Publications
 CDK7 antibody  >52 publications with CCNH and CDK7
 CDK2 antibody  >23 publications with CCNH and CDK2
 XPC antibody  >9 publications with CCNH and XPC
 MNAT1 antibody  >7 publications with CCNH and MNAT1
 CDK8 antibody  >4 publications with CCNH and CDK8
 ERCC2 antibody  >4 publications with CCNH and ERCC2
 CDK9 antibody  >1 publications with CCNH and CDK9
 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cyclin A/B1 Associated Events During G2/M Transition Pathway antibodies  Cyclin A/B1 Associated Events During G2/M Transition Pathway Diagram
 Cyclin A:Cdk2-associated Events At S Phase Entry Pathway antibodies  Cyclin A:Cdk2-associated Events At S Phase Entry Pathway Diagram
 Cyclin D Associated Events In G1 Pathway antibodies  Cyclin D Associated Events In G1 Pathway Diagram
Diseases associated with anti-CCNH antibodyOrgans/Tissues associated with anti-CCNH antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >10 publications with CCNH and Carcinoma
 Prostatic Diseases Antibodies  >6 publications with CCNH and Prostatic Diseases
 Neoplasm Metastasis Antibodies  >4 publications with CCNH and Neoplasm Metastasis
 Brain Diseases Antibodies  >3 publications with CCNH and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with CCNH and Carcinoma, Hepatocellular
 Hyperplasia Antibodies  >2 publications with CCNH and Hyperplasia
 Mammary Neoplasms, Experimental Antibodies  >2 publications with CCNH and Mammary Neoplasms, Experimental
 Adenocarcinoma Antibodies  >2 publications with CCNH and Adenocarcinoma
 Urinary Bladder Neoplasms Antibodies  >2 publications with CCNH and Urinary Bladder Neoplasms
 Liver Diseases Antibodies  >2 publications with CCNH and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with CCNH and Blood
 Prostate Antibodies  >8 publications with CCNH and Prostate
 Lung Antibodies  >5 publications with CCNH and Lung
 Liver Antibodies  >4 publications with CCNH and Liver
 Brain Antibodies  >4 publications with CCNH and Brain
 Skin Antibodies  >3 publications with CCNH and Skin
 Bone Antibodies  >2 publications with CCNH and Bone
 Lymph Node Antibodies  >2 publications with CCNH and Lymph Node
 Vascular Antibodies  >2 publications with CCNH and Vascular
 Bladder Antibodies  >2 publications with CCNH and Bladder
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