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anti-CCR7 antibody :: Rat anti-Mouse CCR7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS633430 anti-CCR7 antibody
Unit / Price
100 Tests  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCR7, Monoclonal Antibody

 Also Known As   

CCR7 (Chemokine Receptor 7, CC-CCR-7) (PE)

 Product Synonym Names    Anti -CCR7 (Chemokine Receptor 7, CC-CCR-7) (PE)
 Product Gene Name   

anti-CCR7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (38710021..38721736, complement). Location: 17q12-q21.2
 OMIM    600242
 3D Structure    ModBase 3D Structure for P32248
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    8H212
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse CCR7.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.1% sodium azide. Conjugated to PE.
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 Immunogen    RBC-2H3 cells expressing mCCR7
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CCR7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CCR7 antibody

   CCR7 is a 7 transmembrane G protein coupled chemokine receptor. CCR7 is expressed on T cells and mature dendritic cells and transduces chemotactic signals in response to CCL19 and CCL21. Mouse CCR7 shares 87% amino acid sequence identity with human CCR7.
 Product Categories/Family for anti-CCR7 antibody    Antibodies; Abs to G Proteins
 Applications Tested/Suitable for anti-CCR7 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-CCR7 antibody    Suitable for use in Flow Cytometry.
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NCBI/Uniprot data below describe general gene information for CCR7. It may not necessarily be applicable to this product.
 NCBI GI #    4502641
 NCBI GeneID    1236
 NCBI Accession #    NP_001829.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001838.3 [Other Products]
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 UniProt Primary Accession #    P32248 [Other Products]
 UniProt Related Accession #    P32248 [Other Products]
 Molecular Weight    42,874 Da [Similar Products]
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 NCBI Official Full Name    C-C chemokine receptor type 7
 NCBI Official Synonym Full Names    chemokine (C-C motif) receptor 7
 NCBI Official Symbol    CCR7 [Similar Products]
 NCBI Official Synonym Symbols   
BLR2; EBI1; CD197; CDw197; CMKBR7
[Similar Products]
 NCBI Protein Information    C-C chemokine receptor type 7; CCR-7; CC-CKR-7; C-C CKR-7; OTTHUMP00000164532; MIP-3 beta receptor; CC chemokine receptor 7; chemokine (C-C) receptor 7; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; lymphocyte-specific G protein-coupled peptide receptor; epstein-Barr virus-induced G-protein coupled receptor 1
 UniProt Protein Name    C-C chemokine receptor type 7
 UniProt Synonym Protein Names   
BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor
 Protein Family    C-C chemokine receptor
 UniProt Gene Name    CCR7 [Similar Products]
 UniProt Synonym Gene Names    CMKBR7; EBI1; EVI1 [Similar Products]
 UniProt Entry Name    CCR7_HUMAN
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 NCBI Summary for CCR7    The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [provided by RefSeq]
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 UniProt Comments for CCR7    CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q12-q21.2

Cellular Component: cell surface; integral to membrane; plasma membrane; intracellular; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; C-C chemokine receptor activity

Biological Process: positive regulation of cell adhesion; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of JNK cascade; response to lipopolysaccharide; elevation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; positive regulation of humoral immune response; dendritic cell chemotaxis; establishment of T cell polarity; inflammatory response; positive regulation of cell-matrix adhesion; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hypersensitivity; positive regulation of phosphoinositide 3-kinase activity; negative thymic T cell selection; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; positive regulation of pseudopodium formation; myeloid dendritic cell chemotaxis; positive regulation of actin filament polymerization; regulation of interferon-gamma production; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; ruffle organization and biogenesis; regulation of interleukin-1 beta secretion; immune response
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 Research Articles on CCR7    1. Studies indicate that the mechanisms that regulate the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCR7 antibodyPathways associated with anti-CCR7 antibody
 Reference Product  PubMed Publications
 CCL21 antibody  >352 publications with CCR7 and CCL21
 CCL19 antibody  >323 publications with CCR7 and CCL19
 CCR10 antibody  >31 publications with CCR7 and CCR10
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with anti-CCR7 antibodyOrgans/Tissues associated with anti-CCR7 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >389 publications with CCR7 and Neoplasms
 Inflammation Antibodies  >242 publications with CCR7 and Inflammation
 Carcinoma Antibodies  >100 publications with CCR7 and Carcinoma
 Leukemia Antibodies  >93 publications with CCR7 and Leukemia
 Lung Diseases Antibodies  >85 publications with CCR7 and Lung Diseases
 Lymphoma Antibodies  >81 publications with CCR7 and Lymphoma
 Melanoma Antibodies  >80 publications with CCR7 and Melanoma
 Neoplasms, Experimental Antibodies  >63 publications with CCR7 and Neoplasms, Experimental
 Vascular Diseases Antibodies  >56 publications with CCR7 and Vascular Diseases
 Liver Diseases Antibodies  >50 publications with CCR7 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1417 publications with CCR7 and Blood
 Lymph Node Antibodies  >580 publications with CCR7 and Lymph Node
 Bone Marrow Antibodies  >173 publications with CCR7 and Bone Marrow
 Lung Antibodies  >131 publications with CCR7 and Lung
 Spleen Antibodies  >127 publications with CCR7 and Spleen
 Thymus Antibodies  >81 publications with CCR7 and Thymus
 Intestine Antibodies  >52 publications with CCR7 and Intestine
 Brain Antibodies  >42 publications with CCR7 and Brain
 Embryonic Tissue Antibodies  >26 publications with CCR7 and Embryonic Tissue
 Pharynx Antibodies  >20 publications with CCR7 and Pharynx
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