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anti-CD 45 antibody :: Rabbit anti-Human CD 45 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS684007
Testing Data
Unit / Price
1 ml (Prediluted)  /  $175 +1 FREE 8GB USB
0.04 mL  /  $185 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
7 ml (Prediluted)  /  $335 +1 FREE 8GB USB
0.2 mL  /  $415 +1 FREE 8GB USB
15 ml (Prediluted)  /  $480 +1 FREE 8GB USB
0.5 mL  /  $515 +1 FREE 8GB USB
1 mL  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD 45, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti - CD 45

 Product Gene Name   

anti-CD 45 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.11 (198638968..198757476). Location: 1q31-q32
 OMIM    126200
 3D Structure    ModBase 3D Structure for P08575
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 Clonality    Monoclonal
 Clone Number    E19-G
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
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 Immunogen    Peptide derived from C-terminal sequence of human CD 45
 Storage Buffer    20 mM Tris-HCI, pH 8.0
 Stabilizer    20 mg/ml BSA
 Preservative    0.05% NaN3
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 Preparation and Storage    Store at +4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Other Notes    Small volumes of anti-CD 45 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD 45 antibody   

Immunohistochemistry (IHC) - Formalin/Paraffin

 Application Notes for anti-CD 45 antibody    IHC-P dilution 1:100 - 1:1 000; IHC-Fr application and dilution to be tested by the user
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 Testing Data of anti-CD 45 antibody    anti-CD 45 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD 45. It may not necessarily be applicable to this product.
 NCBI GI #    33112650
 NCBI GeneID    5788
 NCBI Accession #    P08575.2 [Other Products]
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 UniProt Primary Accession #    P08575 [Other Products]
 UniProt Secondary Accession #    Q16614; Q9H0Y6; A8K7W6 [Other Products]
 UniProt Related Accession #    P08575 [Other Products]
 Molecular Weight    147,254 Da
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 NCBI Official Full Name    Receptor-type tyrosine-protein phosphatase C
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, C
 NCBI Official Symbol    PTPRC [Similar Products]
 NCBI Official Synonym Symbols   
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase C
 UniProt Synonym Protein Names   
Leukocyte common antigen; L-CA; T200
 UniProt Gene Name    PTPRC [Similar Products]
 UniProt Synonym Gene Names    CD45; L-CA [Similar Products]
 UniProt Entry Name    PTPRC_HUMAN
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 NCBI Summary for CD 45    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
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 UniProt Comments for CD 45    Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity

By similarity. Ref.6 Ref.8

Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure: Binds GANAB and PRKCSH

By similarity. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Ref.8 Ref.9

Subcellular location: Membrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Ref.9

Domain: The first PTPase domain interacts with SKAP1.

Post-translational modification: Heavily N- and O-glycosylated.

Involvement in disease: Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16 Ref.17Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Ref.16

Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.Contains 2 fibronectin type-III domains.Contains 2 tyrosine-protein phosphatase domains.
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 Research Articles on CD 45    1. spatial regulation of Lck by CD45 and GM1 ganglioside determines the outcome of apoptotic response to Gal-1 and this local regulation may occur only upon intimate effector (Gal-1 expressing) cell-T-cell attachment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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