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anti-CD103 antibody :: Hamster CD103 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219538 anti-CD103 antibody
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD103, Monoclonal Antibody

 Also Known As   

HAMSTER ANTI MOUSE CD103

 Product Gene Name   

anti-CD103 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q60677
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    2E7
 Host    Hamster
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 0.5mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Mouse intestinal intraepithelial lymphocytes
Buffer Solution
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD103 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD103 antibody

   Hamster anti Mouse CD103 antibody, clone 2E7 recognizes mouse CD103, otherwise known as Integrin alpha-E. CD103 binds Integrin beta 7 to form the heterodimeric integrin molecule aEbeta7. This complex is sometimes referred to as CD103, though strictly speaking CD103 only refers to the alpha chain. The beta 7 subunit can also interact with other integrin alpha chains. The aEbeta7 complex is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. CD103 is expressed on intestinal intraepithelial lymphocytes and is highly expressed on regulatory T cells.Hamster anti Mouse CD103 antibody, clone 2E7 has been reported to also recognize the aEbeta7 complex.
 Applications Tested/Suitable for anti-CD103 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP)

 Application Notes for anti-CD103 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/20
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NCBI/Uniprot data below describe general gene information for CD103. It may not necessarily be applicable to this product.
 NCBI GI #    226823202
 NCBI GeneID    16407
 NCBI Accession #    NP_032425.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008399.2 [Other Products]
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 UniProt Primary Accession #    Q60677 [Other Products]
 UniProt Secondary Accession #    B1AUD5 [Other Products]
 UniProt Related Accession #    Q60677 [Other Products]
 Molecular Weight    128,906 Da
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 NCBI Official Full Name    integrin alpha-E isoform 1
 NCBI Official Synonym Full Names    integrin alpha E, epithelial-associated
 NCBI Official Symbol    Itgae [Similar Products]
 NCBI Official Synonym Symbols   
CD103; aM290; alpha-E1; A530055J10; alpha-M290
[Similar Products]
 NCBI Protein Information    integrin alpha-E; integrin alpha M290
 UniProt Protein Name    Integrin alpha-E
 UniProt Synonym Protein Names   
Integrin alpha M290; CD_antigen: CD103Cleaved into the following 2 chains:Integrin alpha-E light chain; Integrin alpha-E heavy chain
 UniProt Gene Name    Itgae [Similar Products]
 UniProt Entry Name    ITAE_MOUSE
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 UniProt Comments for CD103    ITGAE: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Belongs to the integrin alpha chain family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: membrane; integral to membrane; integrin complex; external side of plasma membrane

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; cell adhesion
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 Research Articles on CD103    1. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD103 antibodyDiseases associated with anti-CD103 antibody
 Products by Pathway  Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >3 publications with CD103 and Lung Diseases
 Inflammation Antibodies  >3 publications with CD103 and Inflammation
 Skin Diseases Antibodies  >2 publications with CD103 and Skin Diseases
 Adenocarcinoma Antibodies  >1 publications with CD103 and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with CD103 and Lung Neoplasms
 Lymphoma Antibodies  >1 publications with CD103 and Lymphoma
 Heart Diseases Antibodies  >1 publications with CD103 and Heart Diseases
 Pneumonia Antibodies  >1 publications with CD103 and Pneumonia
 Neoplasms, Experimental Antibodies  >1 publications with CD103 and Neoplasms, Experimental
 Fibrosis Antibodies  >1 publications with CD103 and Fibrosis
Organs/Tissues associated with anti-CD103 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with CD103 and Skin
 Embryonic Tissue Antibodies  >1 publications with CD103 and Embryonic Tissue
 Testis Antibodies  >1 publications with CD103 and Testis
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