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anti-CD105 antibody :: Mouse anti-Human CD105 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850485
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD105, Monoclonal Antibody

 Also Known As   

CD105 Antibody

 Product Synonym Names    ENG; END; ORW; HHT1; ORW1; CD105; FLJ41744
 Product Gene Name   

anti-CD105 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 187300
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 Clonality    Monoclonal
 Clone Number    3A9
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human CD105 expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-CD105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD105 antibody

   Background: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
 Product Categories/Family for anti-CD105 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CD105 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-CD105 antibody    WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF: 1/200 - 1/1000, FC: 1/200 - 1/400, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-CD105 antibody    Figure 1: Western blot analysis using CD105 mAb against HEK293 (1) and CD105-hIgGFc transfected HEK293 (2) cell lysate.
anti-CD105 antibody Testing Data image
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 Testing Data #2 of anti-CD105 antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded kidney cancer tissues (left) and stomach cancer tissues (right) using CD105 mouse mAb with DAB staining.
anti-CD105 antibody Testing Data #2 image
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 Testing Data #3 of anti-CD105 antibody    anti-CD105 antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for CD105. It may not necessarily be applicable to this product.
 NCBI GI #    4557555
 NCBI GeneID    2022
 NCBI Accession #    NP_000109.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000118.3 [Other Products]
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 UniProt Secondary Accession #    Q14248; Q14926; Q5T9C0 [Other Products]
 UniProt Related Accession #    P17813 [Other Products]
 Molecular Weight    71kDa
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 NCBI Official Full Name    endoglin isoform 2
 NCBI Official Synonym Full Names    endoglin
 NCBI Official Symbol    ENG [Similar Products]
 NCBI Official Synonym Symbols   
END; HHT1; ORW1
[Similar Products]
 NCBI Protein Information    endoglin; CD105 antigen
 UniProt Protein Name    Endoglin
 UniProt Synonym Protein Names   
CD_antigen: CD105
 UniProt Gene Name    ENG [Similar Products]
 UniProt Synonym Gene Names    END [Similar Products]
 UniProt Entry Name    EGLN_HUMAN
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 NCBI Summary for CD105    This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for CD105    ENG: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: nucleoplasm; extracellular space; focal adhesion; cell surface; cytoplasm; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; transmembrane receptor activity; protein homodimerization activity; glycosaminoglycan binding; transforming growth factor beta binding; galactose binding; punt binding; activin binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: wound healing; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; response to corticosteroid stimulus; BMP signaling pathway; extracellular matrix disassembly; smooth muscle development; venous blood vessel morphogenesis; regulation of transforming growth factor beta receptor signaling pathway; central nervous system vasculogenesis; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; chronological cell aging; cell adhesion; vasculogenesis; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of cell adhesion; cell migration; regulation of phosphorylation; negative regulation of nitric-oxide synthase activity; regulation of cell proliferation; patterning of blood vessels; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber
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 Research Articles on CD105    1. Expression of CD105 (a marker of microvascular density) in laryngeal squamous cell carcinoma was correlated with EGFR and mTOR expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD105 antibodyPathways associated with anti-CD105 antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >325 publications with CD105 and TGFB1
 ACVRL1 antibody  >157 publications with CD105 and ACVRL1
 BMP2 antibody  >127 publications with CD105 and BMP2
 SMAD4 antibody  >48 publications with CD105 and SMAD4
 HIF1A antibody  >37 publications with CD105 and HIF1A
 TGFBR2 antibody  >6 publications with CD105 and TGFBR2
 TGFBR1 antibody  >5 publications with CD105 and TGFBR1
 CDH5 antibody  >1 publications with CD105 and CDH5
 TGFBI antibody  >1 publications with CD105 and TGFBI
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-CD105 antibodyOrgans/Tissues associated with anti-CD105 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6317 publications with CD105 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5506 publications with CD105 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2873 publications with CD105 and Heart Diseases
 Breast Neoplasms Antibodies  >744 publications with CD105 and Breast Neoplasms
 Disease Models, Animal Antibodies  >717 publications with CD105 and Disease Models, Animal
 Inflammation Antibodies  >607 publications with CD105 and Inflammation
 Hypertension Antibodies  >586 publications with CD105 and Hypertension
 Liver Diseases Antibodies  >463 publications with CD105 and Liver Diseases
 Atherosclerosis Antibodies  >427 publications with CD105 and Atherosclerosis
 Necrosis Antibodies  >394 publications with CD105 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10890 publications with CD105 and Blood
 Bone Antibodies  >7717 publications with CD105 and Bone
 Heart Antibodies  >7585 publications with CD105 and Heart
 Brain Antibodies  >7469 publications with CD105 and Brain
 Muscle Antibodies  >6727 publications with CD105 and Muscle
 Vascular Antibodies  >6635 publications with CD105 and Vascular
 Nerve Antibodies  >2848 publications with CD105 and Nerve
 Skin Antibodies  >2766 publications with CD105 and Skin
 Connective Tissue Antibodies  >2350 publications with CD105 and Connective Tissue
 Eye Antibodies  >1953 publications with CD105 and Eye
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