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anti-CD106 antibody :: Mouse CD106 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214615
Testing Data
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD106, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD106:FITC

 Product Gene Name   

anti-CD106 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    192225
 3D Structure    ModBase 3D Structure for P19320
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1.G11B1
 Host    Mouse
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
0.1% Bovine Serum Albumin
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD106 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD106 antibody

   Mouse anti Human CD106 antibody, clone 1.G11B1 recognizes human VCAM-1, a 110kD molecule whose ligand is VLA4. The antigen is expressed on activated endothelial cells and on some tissue macrophages, bone marrow fibroblasts and myoblasts. Mouse anti Human CD106 antibody, clone 1.G11B1 inhibits cellular adhesion mediated by VCAM-1.
 Applications Tested/Suitable for anti-CD106 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD106 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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 Testing Data of anti-CD106 antibody    KM-H2 cells stained with Mouse anti Human CD106 (MBS213194)
anti-CD106 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD106. It may not necessarily be applicable to this product.
 NCBI GI #    4507875
 NCBI GeneID    7412
 NCBI Accession #    NP_001069.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001078.3 [Other Products]
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 UniProt Primary Accession #    P19320 [Other Products]
 UniProt Secondary Accession #    Q6NUP8; A8K6R7; B4DKS4; E9PDD1 [Other Products]
 UniProt Related Accession #    P19320 [Other Products]
 Molecular Weight    74,346 Da
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 NCBI Official Full Name    vascular cell adhesion protein 1 isoform a
 NCBI Official Synonym Full Names    vascular cell adhesion molecule 1
 NCBI Official Symbol    VCAM1 [Similar Products]
 NCBI Official Synonym Symbols   
CD106; INCAM-100
[Similar Products]
 NCBI Protein Information    vascular cell adhesion protein 1; CD106 antigen
 UniProt Protein Name    Vascular cell adhesion protein 1
 UniProt Synonym Protein Names   
INCAM-100; CD_antigen: CD106
 UniProt Gene Name    VCAM1 [Similar Products]
 UniProt Synonym Gene Names    L1CAM; V-CAM 1; VCAM-1 [Similar Products]
 UniProt Entry Name    VCAM1_HUMAN
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 NCBI Summary for CD106    This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for CD106    VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium

Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding

Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; heart development; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; amine metabolic process; response to ionizing radiation; leukocyte tethering or rolling; cell adhesion; response to nutrient; acute inflammatory response; aging
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 Research Articles on CD106    1. Data show that VCAM-1 (CD106) physically associates with CD44 antigen.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD106 antibodyPathways associated with anti-CD106 antibody
 Reference Product  PubMed Publications
 CD44 antibody  >14 publications with CD106 and CD44
 ITGA4 antibody  >10 publications with CD106 and ITGA4
 ITGB2 antibody  >6 publications with CD106 and ITGB2
 ITGB1 antibody  >3 publications with CD106 and ITGB1
 VEGFA antibody  >3 publications with CD106 and VEGFA
 SRC antibody  >2 publications with CD106 and SRC
 ITGAD antibody  >1 publications with CD106 and ITGAD
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-CD106 antibodyOrgans/Tissues associated with anti-CD106 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >86 publications with CD106 and Inflammation
 Cardiovascular Diseases Antibodies  >54 publications with CD106 and Cardiovascular Diseases
 Necrosis Antibodies  >50 publications with CD106 and Necrosis
 Atherosclerosis Antibodies  >42 publications with CD106 and Atherosclerosis
 Kidney Diseases Antibodies  >13 publications with CD106 and Kidney Diseases
 Hypertension Antibodies  >12 publications with CD106 and Hypertension
 Heart Diseases Antibodies  >11 publications with CD106 and Heart Diseases
 Myocardial Ischemia Antibodies  >9 publications with CD106 and Myocardial Ischemia
 Anemia Antibodies  >8 publications with CD106 and Anemia
 Myocardial Infarction Antibodies  >7 publications with CD106 and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >202 publications with CD106 and Vascular
 Blood Antibodies  >122 publications with CD106 and Blood
 Kidney Antibodies  >24 publications with CD106 and Kidney
 Embryonic Tissue Antibodies  >22 publications with CD106 and Embryonic Tissue
 Brain Antibodies  >20 publications with CD106 and Brain
 Heart Antibodies  >17 publications with CD106 and Heart
 Liver Antibodies  >15 publications with CD106 and Liver
 Lung Antibodies  >13 publications with CD106 and Lung
 Skin Antibodies  >8 publications with CD106 and Skin
 Placenta Antibodies  >8 publications with CD106 and Placenta
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