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anti-CD226 antibody :: Mouse CD112 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600233 anti-CD226 antibody
Unit / Price
0.2 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD112 (CD226), Monoclonal Antibody

★Popular Item★
 Also Known As   

CD112 (Poliovirus Receptor Related 2, PRR2)

 Product Synonym Names    Anti -CD112 (Poliovirus Receptor Related 2, PRR2)
 Product Gene Name   

anti-CD226 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_000018.9 (67530192..67624412, complement). Location: 18q22.3
 OMIM    605397
 3D Structure    ModBase 3D Structure for Q15762
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3H1817
 Host    Mouse
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 Specificity    Recognizes human CD112.
 Purity/Purification    Purified by Protein G affinity chromatography from tissue culture supernatant.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Grade    Affinity Purified
 Recommended Secondary Antibody    (Please inquire MBS):IgG, Fc(HRP) Pab Gt xMo

MBS616316: IgG, X-Adsorbed (FITC) Pab Gt xMo

 Recommended Negative Control    MBS655746: IgG1 Murine Negative Control
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 Preparation and Storage    May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-CD226 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD226 antibody

   CD112 Poliovirus Receptor Related 2 (PRR2), is a new surface molecule, which has been reported to be homologous to the poliovirus receptor (CD155). Studies demonstrate that PRR2 expression is restrictred to the myelomonocytic and megakaryocytic lineages. PRR2 expresion has also been detected on haematopoeitic progenitors expressing CD34.
 Product Categories/Family for anti-CD226 antibody    Antibodies; Abs to CD Markers
 Applications Tested/Suitable for anti-CD226 antibody   

Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation.

Not recommended for use in Western Blot.

Other applications have not been tested.

 Application Notes for anti-CD226 antibody    Immunohistochemistry: Frozen sections

Flow Cytometry: 1:50-1:100. Use 10ul to label 10e6 cells in 100ul.

Optimal working dilutions to be determined by researcher.
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NCBI/Uniprot data below describe general gene information for CD226. It may not necessarily be applicable to this product.
 NCBI GI #    317373338
 NCBI GeneID    10666
 NCBI Accession #    Q15762.2 [Other Products]
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 UniProt Primary Accession #    Q15762 [Other Products]
 UniProt Secondary Accession #    B2R818 [Other Products]
 UniProt Related Accession #    Q15762 [Other Products]
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 NCBI Official Full Name    CD226 antigen
 NCBI Official Synonym Full Names    CD226 molecule
 NCBI Official Symbol    CD226 [Similar Products]
 NCBI Official Synonym Symbols   
PTA1; DNAM1; DNAM-1; TLiSA1
[Similar Products]
 NCBI Protein Information    CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen
 UniProt Protein Name    CD226 antigen
 UniProt Synonym Protein Names   
DNAX accessory molecule 1
 Protein Family    CD226 antigen
 UniProt Gene Name    CD226 [Similar Products]
 UniProt Synonym Gene Names    DNAM1; DNAM-1 [Similar Products]
 UniProt Entry Name    CD226_HUMAN
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 NCBI Summary for CD226    This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD226    DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; cell adhesion; signal transduction; positive regulation of mast cell activation
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 Research Articles on CD226    1. Overexpression of DNAM-1 was detected in the skin of patients with SSc (systemic sclerosis)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD226 antibodyPathways associated with anti-CD226 antibody
 Reference Product  PubMed Publications
 KLRK1 antibody  >21 publications with CD226 and KLRK1
 NCR1 antibody  >10 publications with CD226 and NCR1
 NCR3 antibody  >6 publications with CD226 and NCR3
 FYN antibody  >5 publications with CD226 and FYN
 ITGAL antibody  >3 publications with CD226 and ITGAL
 ITGB2 antibody  >2 publications with CD226 and ITGB2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with anti-CD226 antibodyOrgans/Tissues associated with anti-CD226 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >52 publications with CD226 and Immune System Diseases
 Neoplasms Antibodies  >49 publications with CD226 and Neoplasms
 Nervous System Diseases Antibodies  >12 publications with CD226 and Nervous System Diseases
 Inflammation Antibodies  >11 publications with CD226 and Inflammation
 Necrosis Antibodies  >11 publications with CD226 and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with CD226 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >8 publications with CD226 and Diabetes Mellitus, Type 1
 Respiratory Tract Diseases Antibodies  >8 publications with CD226 and Respiratory Tract Diseases
 Colorectal Neoplasms Antibodies  >7 publications with CD226 and Colorectal Neoplasms
 Bone Diseases Antibodies  >4 publications with CD226 and Bone Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with CD226 and Blood
 Vascular Antibodies  >8 publications with CD226 and Vascular
 Lung Antibodies  >7 publications with CD226 and Lung
 Lymph Node Antibodies  >6 publications with CD226 and Lymph Node
 Liver Antibodies  >6 publications with CD226 and Liver
 Spleen Antibodies  >5 publications with CD226 and Spleen
 Thymus Antibodies  >3 publications with CD226 and Thymus
 Mixed Antibodies  >3 publications with CD226 and Mixed
 Uterus Antibodies  >2 publications with CD226 and Uterus
 Kidney Antibodies  >1 publications with CD226 and Kidney
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