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anti-CD115 antibody :: Rat CD115 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS235353
Testing Data #1
Unit / Price
25 Tests  /  $195 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD115, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD115:RPE

 Product Gene Name   

anti-CD115 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P09581
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    604B5 2E11
 Host    Rat
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 Form/Format    Purified IgG - liquid
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
5% Glycerol
Preparation
 Immunogen    RAW 264 cells
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of anti-CD115 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD115 antibody

   Rat anti Mouse CD115 antibody, clone 604B5 2E11 recognizes the murine CD115 cell surface antigen, also known as the M-CSF receptor and as c-fms. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Rat anti Mouse CD115 antibody, clone 604B5 2E11 has been shown to inhibit in vitro colony formation in response to M-CSF in both rats and mice.
 Applications Tested/Suitable for anti-CD115 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD115 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data #1 of anti-CD115 antibody    Staining of the mouse J774 cell line with Rat anti Mouse CD115 : RPE (MBS215327)
anti-CD115 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for CD115. It may not necessarily be applicable to this product.
 NCBI GI #    126723423
 NCBI GeneID    12978
 NCBI Accession #    NP_001032948.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001037859.2 [Other Products]
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 UniProt Primary Accession #    P09581 [Other Products]
 UniProt Secondary Accession #    Q3U3P1; Q9DBH9 [Other Products]
 UniProt Related Accession #    P09581 [Other Products]
 Molecular Weight    109,179 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    Csf1r [Similar Products]
 NCBI Official Synonym Symbols   
Fms; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; c-fms; proto-oncogene c-Fms; proto-oncogene fms
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 UniProt Gene Name    Csf1r [Similar Products]
 UniProt Synonym Gene Names    Csfmr; Fms; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
 UniProt Entry Name    CSF1R_MOUSE
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 UniProt Comments for CD115    CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: Oncoprotein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TK; TK group; PDGFR family

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; intracellular; receptor complex

Molecular Function: transferase activity; macrophage colony stimulating factor receptor activity; protein binding; protein homodimerization activity; cytokine binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding; protein kinase activity

Biological Process: regulation of bone resorption; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; immune system process; positive regulation of osteoclast differentiation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; osteoclast differentiation; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; cell proliferation; regulation of cell shape; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; positive regulation of protein amino acid phosphorylation; phosphatidylinositol metabolic process; intercellular junction maintenance; inflammatory response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
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 Research Articles on CD115    1. All-lymphoid progenitors ALPs express higher levels of CSF1R transcripts than their upstream precursors, but only limited cell-surface CSF1R expression. ADAM17 knockouts have more CSF1R surface expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD115 antibodyDiseases associated with anti-CD115 antibody
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1287 publications with CD115 and Necrosis
 Inflammation Antibodies  >735 publications with CD115 and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >380 publications with CD115 and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >303 publications with CD115 and Lung Diseases
 Cardiovascular Diseases Antibodies  >172 publications with CD115 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >169 publications with CD115 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >165 publications with CD115 and Breast Neoplasms
 Lymphoma Antibodies  >160 publications with CD115 and Lymphoma
 Lung Neoplasms Antibodies  >79 publications with CD115 and Lung Neoplasms
 Kidney Diseases Antibodies  >70 publications with CD115 and Kidney Diseases
Organs/Tissues associated with anti-CD115 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3195 publications with CD115 and Blood
 Bone Antibodies  >1986 publications with CD115 and Bone
 Bone Marrow Antibodies  >1449 publications with CD115 and Bone Marrow
 Lung Antibodies  >424 publications with CD115 and Lung
 Spleen Antibodies  >273 publications with CD115 and Spleen
 Brain Antibodies  >254 publications with CD115 and Brain
 Liver Antibodies  >206 publications with CD115 and Liver
 Skin Antibodies  >197 publications with CD115 and Skin
 Joint Antibodies  >163 publications with CD115 and Joint
 Kidney Antibodies  >136 publications with CD115 and Kidney
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