NP_001116205.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,814 Da
NCBI Official Full Name
mast/stem cell growth factor receptor Kit isoform 1
NCBI Official Synonym Full Names
kit oncogene
NCBI Official Synonym Symbols
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3 [Similar Products]
NCBI Protein Information
mast/stem cell growth factor receptor Kit; Dominant white spotting; SCFR; Steel Factor Receptor; belly-spot; c-kit proto-oncogene protein; dominant spotting; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; spotted sterile male
UniProt Protein Name
Mast/stem cell growth factor receptor Kit
UniProt Synonym Protein Names
Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; CD_antigen: CD117
UniProt Synonym Gene Names
UniProt Entry Name
KIT_MOUSE
NCBI Summary for CD117
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CD117
Kit: a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes.
Protein type: EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; PDGFR family
Cellular Component: extracellular space; internal side of plasma membrane; cell surface; mast cell granule; membrane; cytoplasm; plasma membrane; acrosome; integral to membrane; intercellular junction; intracellular; external side of plasma membrane
Molecular Function: protein homodimerization activity; protease binding; metal ion binding; nucleotide binding; stem cell factor receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; cytokine binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: somatic stem cell maintenance; activation of MAPK activity; germ cell programmed cell death; positive regulation of JAK-STAT cascade; lymphoid progenitor cell differentiation; positive regulation of long-term neuronal synaptic plasticity; protein amino acid phosphorylation; germ cell development; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; positive regulation of MAP kinase activity; epithelial cell proliferation; germ cell migration; somatic stem cell division; erythrocyte differentiation; T cell differentiation; embryonic hemopoiesis; mast cell chemotaxis; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of transcription factor activity; glycosphingolipid metabolic process; immature B cell differentiation; regulation of pigmentation during development; mast cell cytokine production; transmembrane receptor protein tyrosine kinase signaling pathway; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; pigmentation during development; chemotaxis; response to radiation; positive regulation of MAPKKK cascade; myeloid progenitor cell differentiation; ovarian follicle development; positive regulation of cell proliferation; melanocyte differentiation; negative regulation of programmed cell death; visual learning; hemopoiesis; inflammatory response; cell differentiation; positive regulation of Notch signaling pathway; lamellipodium biogenesis; dendritic cell cytokine production; cytokine and chemokine mediated signaling pathway; mast cell degranulation; positive regulation of pseudopodium formation; gut development; pigmentation; positive regulation of tyrosine phosphorylation of Stat5 protein; actin cytoskeleton reorganization; myeloid leukocyte differentiation; spermatogenesis; phosphorylation; spermatid development; positive regulation of cell migration
Research Articles on CD117
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Pathways associated with anti-CD117 antibody
Diseases associated with anti-CD117 antibody
Organs/Tissues associated with anti-CD117 antibody
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