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anti-CD117 antibody :: Mouse CD117 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215263 anti-CD117 antibody
Unit / Price
25 Tests  /  $200 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD117, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD117:RPE

 Product Gene Name   

anti-CD117 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164920
 3D Structure    ModBase 3D Structure for P10721
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    104D2
 Host    Mouse
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 Form/Format    Purified IgG conjugated to R. Phycoerythrin (RPE) - liquid
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 Perservative Stabilisers    0.09% Sodium Azide
0.2% Bovine Serum Albumin
 Immunogen    MOLM-1 megakaryocytic cell line.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 6 months from date of despatch.
 Other Notes    Small volumes of anti-CD117 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD117 antibody

   Mouse anti Human CD117 antibody, clone 104D2 recognizes the human CD117 cell surface antigen, a 145kDa glycoprotein also known as c-kit. CD117 is expressed by some haematopoietic stem cells (approx. 70% of CD34+ve cells in normal bone marrow are CD117+ve), some acute myeloid leukaemias and by mast cells. Functionally CD117 is a receptor for stem cell factor, and has receptor tyrosine kinase activity. Mouse anti Human CD117 antibody, clone 104D2 is non-neutralising.
 Applications Tested/Suitable for anti-CD117 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD117 antibody    Flow Cytometry: Use 20 ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Maximum Dilution: Neat
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NCBI/Uniprot data below describe general gene information for CD117. It may not necessarily be applicable to this product.
 NCBI GI #    4557695
 NCBI GeneID    3815
 NCBI Accession #    NP_000213.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000222.2 [Other Products]
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 UniProt Primary Accession #    P10721 [Other Products]
 UniProt Secondary Accession #    Q6IQ28; Q99662; Q9UM99; B5A956; D5LXN2; D5M931; F5H8F8 [Other Products]
 UniProt Related Accession #    P10721 [Other Products]
 Molecular Weight    46,658 Da
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 NCBI Official Full Name    mast/stem cell growth factor receptor Kit isoform 1
 NCBI Official Synonym Full Names    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 NCBI Official Symbol    KIT [Similar Products]
 NCBI Official Synonym Symbols   
PBT; SCFR; C-Kit; CD117
[Similar Products]
 NCBI Protein Information    mast/stem cell growth factor receptor Kit; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; soluble KIT variant 1; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
 UniProt Protein Name    Mast/stem cell growth factor receptor Kit
 UniProt Synonym Protein Names   
Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD_antigen: CD117
 UniProt Gene Name    KIT [Similar Products]
 UniProt Synonym Gene Names    SCFR; SCFR; PBT [Similar Products]
 UniProt Entry Name    KIT_HUMAN
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 NCBI Summary for CD117    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD117    Kit: a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes.

Protein type: Protein kinase, TK; Membrane protein, integral; Oncoprotein; EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; PDGFR family

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular space; internal side of plasma membrane; mast cell granule; plasma membrane; integral to membrane; acrosome; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protease binding; protein-tyrosine kinase activity; metal ion binding; cytokine binding; stem cell factor receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; somatic stem cell maintenance; activation of MAPK activity; germ cell programmed cell death; positive regulation of JAK-STAT cascade; lymphoid progenitor cell differentiation; positive regulation of long-term neuronal synaptic plasticity; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; epithelial cell proliferation; germ cell migration; erythrocyte differentiation; somatic stem cell division; T cell differentiation; fibroblast growth factor receptor signaling pathway; embryonic hemopoiesis; mast cell chemotaxis; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of pigmentation during development; glycosphingolipid metabolic process; immature B cell differentiation; positive regulation of transcription factor activity; mast cell cytokine production; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; signal transduction; positive regulation of MAPKKK cascade; myeloid progenitor cell differentiation; ovarian follicle development; melanocyte differentiation; positive regulation of cell proliferation; negative regulation of programmed cell death; visual learning; hemopoiesis; inflammatory response; positive regulation of Notch signaling pathway; epidermal growth factor receptor signaling pathway; lamellipodium biogenesis; phosphoinositide-mediated signaling; dendritic cell cytokine production; cytokine and chemokine mediated signaling pathway; male gonad development; stem cell maintenance; positive regulation of phosphoinositide 3-kinase activity; mast cell degranulation; regulation of cell proliferation; positive regulation of pseudopodium formation; pigmentation; positive regulation of tyrosine phosphorylation of Stat5 protein; gut development; actin cytoskeleton reorganization; innate immune response; spermatogenesis; spermatid development; positive regulation of cell migration

Disease: Gastrointestinal Stromal Tumor; Mast Cell Disease; Piebald Trait; Testicular Germ Cell Tumor
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 Research Articles on CD117    1. The study found no correlation between the incidence and types of KIT mutations and its expression on cells in acute myeloid leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD117 antibodyPathways associated with anti-CD117 antibody
 Reference Product  PubMed Publications
 KITLG antibody  >3766 publications with CD117 and KITLG
 JAK2 antibody  >138 publications with CD117 and JAK2
 LYN antibody  >58 publications with CD117 and LYN
 CBL antibody  >58 publications with CD117 and CBL
 GRB2 antibody  >39 publications with CD117 and GRB2
 PTPN11 antibody  >34 publications with CD117 and PTPN11
 TEC antibody  >30 publications with CD117 and TEC
 PTPN6 antibody  >23 publications with CD117 and PTPN6
 GRB7 antibody  >8 publications with CD117 and GRB7
 PIK3R1 antibody  >4 publications with CD117 and PIK3R1
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-CD117 antibodyOrgans/Tissues associated with anti-CD117 antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Stromal Tumors Antibodies  >2269 publications with CD117 and Gastrointestinal Stromal Tumors
 Nervous System Diseases Antibodies  >1309 publications with CD117 and Nervous System Diseases
 Inflammation Antibodies  >1291 publications with CD117 and Inflammation
 Liver Diseases Antibodies  >1278 publications with CD117 and Liver Diseases
 Lung Diseases Antibodies  >1191 publications with CD117 and Lung Diseases
 Adenocarcinoma Antibodies  >1158 publications with CD117 and Adenocarcinoma
 Necrosis Antibodies  >1112 publications with CD117 and Necrosis
 Leukemia, Myeloid, Acute Antibodies  >883 publications with CD117 and Leukemia, Myeloid, Acute
 Heart Diseases Antibodies  >842 publications with CD117 and Heart Diseases
 Breast Neoplasms Antibodies  >695 publications with CD117 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2240 publications with CD117 and Muscle
 Liver Antibodies  >2086 publications with CD117 and Liver
 Skin Antibodies  >1517 publications with CD117 and Skin
 Lung Antibodies  >1464 publications with CD117 and Lung
 Heart Antibodies  >1311 publications with CD117 and Heart
 Intestine Antibodies  >1123 publications with CD117 and Intestine
 Kidney Antibodies  >1027 publications with CD117 and Kidney
 Brain Antibodies  >1019 publications with CD117 and Brain
 Nerve Antibodies  >657 publications with CD117 and Nerve
 Spleen Antibodies  >630 publications with CD117 and Spleen
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