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anti-CD11c antibody :: Hamster CD11c Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210330 anti-CD11c antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD11c, Monoclonal Antibody

 Also Known As   

HAMSTER ANTI MOUSE CD11c:Biotin

 Product Gene Name   

anti-CD11c antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9QXH4
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    N418
 Host    Hamster
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 Form/Format    Biotin
Purified IgG conjugated to Biotin - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Immunogen    Mouse spleen dendritic cells.
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD11c antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD11c antibody

   Hamster anti Mouse CD11c antibody, clone N418 recognizes the murine homolog of human CD11c, a 150/90kDa member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells. Hamster anti Mouse CD11c antibody, clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo (Wang et al. 2000).
 Applications Tested/Suitable for anti-CD11c antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD11c antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Minimum Dilution: neat; Maximum Dilution: 1/5
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NCBI/Uniprot data below describe general gene information for CD11c. It may not necessarily be applicable to this product.
 NCBI GI #    10946646
 NCBI GeneID    16411
 NCBI Accession #    NP_067309.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021334.2 [Other Products]
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 UniProt Primary Accession #    Q9QXH4 [Other Products]
 UniProt Related Accession #    Q9QXH4 [Other Products]
 Molecular Weight    129,151 Da
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 NCBI Official Full Name    integrin alpha-X
 NCBI Official Synonym Full Names    integrin alpha X
 NCBI Official Symbol    Itgax [Similar Products]
 NCBI Official Synonym Symbols   
Cr4; N418; Cd11c; AI449405
[Similar Products]
 NCBI Protein Information    integrin alpha-X; CD11 antigen-like family member C; CD11C (p150) alpha polypeptide; complement receptor 4; integrin aX; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95
 UniProt Protein Name    Integrin alpha-X
 UniProt Synonym Protein Names   
CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c
 UniProt Gene Name    Itgax [Similar Products]
 UniProt Entry Name    ITAX_MOUSE
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 UniProt Comments for CD11c    ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: cell surface; membrane; integral to membrane; integrin complex; external side of plasma membrane

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; activated T cell proliferation; cell adhesion; defense response to virus
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 Research Articles on CD11c    1. these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD11c antibodyDiseases associated with anti-CD11c antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >526 publications with CD11c and Inflammation
 Necrosis Antibodies  >358 publications with CD11c and Necrosis
 Disease Models, Animal Antibodies  >298 publications with CD11c and Disease Models, Animal
 Lung Diseases Antibodies  >167 publications with CD11c and Lung Diseases
 Nervous System Diseases Antibodies  >119 publications with CD11c and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >110 publications with CD11c and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >108 publications with CD11c and Cardiovascular Diseases
 Asthma Antibodies  >70 publications with CD11c and Asthma
 Liver Diseases Antibodies  >60 publications with CD11c and Liver Diseases
 Atherosclerosis Antibodies  >50 publications with CD11c and Atherosclerosis
Organs/Tissues associated with anti-CD11c antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2180 publications with CD11c and Blood
 Bone Antibodies  >569 publications with CD11c and Bone
 Bone Marrow Antibodies  >549 publications with CD11c and Bone Marrow
 Spleen Antibodies  >445 publications with CD11c and Spleen
 Lymph Node Antibodies  >412 publications with CD11c and Lymph Node
 Lung Antibodies  >293 publications with CD11c and Lung
 Skin Antibodies  >245 publications with CD11c and Skin
 Intestine Antibodies  >142 publications with CD11c and Intestine
 Thymus Antibodies  >77 publications with CD11c and Thymus
 Joint Antibodies  >29 publications with CD11c and Joint
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