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anti-CD120a antibody :: Mouse CD120a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214946
Testing Data
Unit / Price
0.025 mg  /  $175 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD120a, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD120a:FITC

 Product Gene Name   

anti-CD120a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142680
 3D Structure    ModBase 3D Structure for P19438
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    H398
 Host    Mouse
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD120a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD120a antibody

   Mouse anti Human CD120a antibody, clone H398 recognizes an extracellular domain of the 55kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the 75kDa TNF receptor (CD120b). CD120a is weakly expressed by monocytes and granulocytes. Mouse anti Human CD120a antibody, clone H398 may be used to detect high levels of TNFR1, in western blotting under reducing conditions, such as recombinant material, but it is not suitable for detection of TNFR1 in normal cells in this application. Mouse anti Human CD120a antibody, clone H398 inhibits the biological activity of both natural and recombinant human TNFalpha and TNFbeta (Thoma et al. 1990and Dri et al. 1999). Mouse anti Human CD120a antibody, clone H398 is routinely tested in flow cytometry on human peripheral blood monocytes.
 Applications Tested/Suitable for anti-CD120a antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD120a antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD120a antibody    Staining of human peripheral blood granulocytes with Mouse anti human CD120a: Alexa Fluor 647 (MBS212106A647)
anti-CD120a antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD120a. It may not necessarily be applicable to this product.
 NCBI GI #    4507575
 NCBI GeneID    7132
 NCBI Accession #    NP_001056.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001065.3 [Other Products]
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 UniProt Primary Accession #    P19438 [Other Products]
 UniProt Secondary Accession #    Q9UCA4; A8K4X3; B2RDE4; B3KPQ1; B4DQB7; B4E309; B5M0B5; D3DUR1 [Other Products]
 UniProt Related Accession #    P19438 [Other Products]
 Molecular Weight    24,194 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 1A
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 1A
 NCBI Official Symbol    TNFRSF1A [Similar Products]
 NCBI Official Synonym Symbols   
FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 1A
 UniProt Synonym Protein Names   
Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD_antigen: CD120aCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI
 UniProt Gene Name    TNFRSF1A [Similar Products]
 UniProt Synonym Gene Names    TNFAR; TNFR1; TNF-R1; TNF-RI; TNFR-I; TBPI [Similar Products]
 UniProt Entry Name    TNR1A_HUMAN
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 NCBI Summary for CD120a    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD120a    TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: Golgi membrane; extracellular space; cell surface; mitochondrion; axon; integral to plasma membrane; plasma membrane; extracellular region; synapse; nucleus; cytosol; receptor complex; lipid raft

Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding

Biological Process: response to alkaloid; viral reproduction; protein heterooligomerization; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway; positive regulation of neuron apoptosis; response to wounding; negative regulation of interleukin-6 production; tetrapyrrole metabolic process; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein import into nucleus, translocation; cytokine and chemokine mediated signaling pathway; response to amino acid stimulus; positive regulation of tumor necrosis factor production; prostaglandin metabolic process; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of inflammatory response; defense response to bacterium; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; positive regulation of inflammatory response; negative regulation of apoptosis

Disease: Periodic Fever, Familial, Autosomal Dominant; Multiple Sclerosis, Susceptibility To, 5
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 Research Articles on CD120a    1. Dysregulation of TNF plays a role in the pathology of many auto-immune diseases. TNF-blocking agents have proven successful in the treatment of such diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD120a antibodyPathways associated with anti-CD120a antibody
 Reference Product  PubMed Publications
 TNF antibody  >428 publications with CD120a and TNF
 FADD antibody  >15 publications with CD120a and FADD
 TRADD antibody  >14 publications with CD120a and TRADD
 TRAF2 antibody  >13 publications with CD120a and TRAF2
 IKBKB antibody  >12 publications with CD120a and IKBKB
 RIPK1 antibody  >11 publications with CD120a and RIPK1
 LTA antibody  >7 publications with CD120a and LTA
 TRAF1 antibody  >3 publications with CD120a and TRAF1
 BIRC2 antibody  >2 publications with CD120a and BIRC2
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
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 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-CD120a antibodyOrgans/Tissues associated with anti-CD120a antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >615 publications with CD120a and Necrosis
 Inflammation Antibodies  >206 publications with CD120a and Inflammation
 Fever Antibodies  >158 publications with CD120a and Fever
 Autoimmune Diseases Antibodies  >97 publications with CD120a and Autoimmune Diseases
 Disease Models, Animal Antibodies  >86 publications with CD120a and Disease Models, Animal
 Pain Antibodies  >67 publications with CD120a and Pain
 Cardiovascular Diseases Antibodies  >66 publications with CD120a and Cardiovascular Diseases
 Heart Diseases Antibodies  >39 publications with CD120a and Heart Diseases
 Multiple Sclerosis Antibodies  >35 publications with CD120a and Multiple Sclerosis
 Liver Diseases Antibodies  >32 publications with CD120a and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >214 publications with CD120a and Blood
 Brain Antibodies  >61 publications with CD120a and Brain
 Liver Antibodies  >52 publications with CD120a and Liver
 Skin Antibodies  >49 publications with CD120a and Skin
 Vascular Antibodies  >48 publications with CD120a and Vascular
 Muscle Antibodies  >47 publications with CD120a and Muscle
 Bone Antibodies  >44 publications with CD120a and Bone
 Lung Antibodies  >37 publications with CD120a and Lung
 Nerve Antibodies  >31 publications with CD120a and Nerve
 Bone Marrow Antibodies  >31 publications with CD120a and Bone Marrow
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