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anti-CD134 antibody :: Mouse anti-Human CD134 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS666154
Testing Data
Unit / Price
120 Tests  /  $470 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD134, Monoclonal Antibody

 Also Known As   

anti-human CD134(OX40)-R-PE

 Product Synonym Names    Monoclonal anti-human CD134 (OX40)/R-PE
 Product Gene Name   

anti-CD134 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615593
 3D Structure    ModBase 3D Structure for P43489
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    BerAct35
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA.
 Concentration    Volume: 0.2 ml (lot specific)
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 Performance    Five x 105 cultured HPB-MLT human tumor cells were washed and incubated 45 minutes on ice with 80 mul of anti-CD134/R-PE at a 1:50 dilution (5 mug/ml). Cells were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 0.85 log10 fluorescent units when compared to a Mouse IgG1/R-PE negative control at a similar concentration. Binding was blocked when cells were pre incubated 10 minutes with 20 mul of 0.5 mg/ml anti-CD134 antibody.
 Conjugation    PE
 Production    Protein A purified antibody from tissue culture supernatant was conjugated to R-Phycoerythrin through a sulfo-ester linkage. Unconjugated antibody was removed using size exclusion chromatography. Antibody conjugate is at 0.25 mg/ml with a A565/A280 ratio of 3.0.
 Buffer    50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative).
 Immunogen    Human HUT 102 T cells
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 Preparation and Storage    Store at 2 - 5 degree C. Do not freeze! Protect from light.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
 Other Notes    Small volumes of anti-CD134 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD134 antibody

   Information: Human CD134 (OX40) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation. Antibody Ber Act 35 recognizes the human CD134 molecule of about 35 kd.
 Applications Tested/Suitable for anti-CD134 antibody   

Flow Cytometry (FC/FACS), ELISA (EIA), Immunohistochemistry (IHC), FX, FPS

 Application Notes for anti-CD134 antibody    1:50 (or use 1.6mul of concentrated stock per 5 x 105-cell test)
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 Testing Data of anti-CD134 antibody    anti-CD134 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD134. It may not necessarily be applicable to this product.
 NCBI GI #    8926702
 NCBI GeneID    7293
 NCBI Accession #    CAB96543.1 [Other Products]
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 UniProt Primary Accession #    P43489 [Other Products]
 UniProt Secondary Accession #    Q13663; Q2M312; Q5T7M0 [Other Products]
 UniProt Related Accession #    P43489 [Other Products]
 Molecular Weight    29,341 Da
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 NCBI Official Full Name    CD134 antigen
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 4
 NCBI Official Symbol    TNFRSF4 [Similar Products]
 NCBI Official Synonym Symbols   
OX40; ACT35; CD134; IMD16; TXGP1L
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 4; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 4
 UniProt Synonym Protein Names   
ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134
 UniProt Gene Name    TNFRSF4 [Similar Products]
 UniProt Synonym Gene Names    TXGP1L [Similar Products]
 UniProt Entry Name    TNR4_HUMAN
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 NCBI Summary for CD134    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD134    TNFRSF4: Receptor for TNFSF4/OX40L/GP34.

Protein type: Apoptosis; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: regulation of apoptosis; T cell proliferation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; regulation of protein kinase activity; inflammatory response

Disease: Immunodeficiency 16
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Product References and Citations for anti-CD134 antibody

   U. Latza et al, Eur J Immunol (1994) 24: 677-683. E. Stuber, et al, (1995) Immunity 2: 507-521. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 464-465. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995) p. 1157-1160.
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 Research Articles on CD134    1. There were no significant associations between rs1234313, rs1234314 and rs17568 and atherosclerotic cerebral infarction risk in a Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD134 antibodyPathways associated with anti-CD134 antibody
 Reference Product  PubMed Publications
 TNFSF4 antibody  >190 publications with CD134 and TNFSF4
 TNFRSF9 antibody  >40 publications with CD134 and TNFRSF9
 IL2RA antibody  >15 publications with CD134 and IL2RA
 TRAF3 antibody  >3 publications with CD134 and TRAF3
 IL2RG antibody  >3 publications with CD134 and IL2RG
 IL2RB antibody  >3 publications with CD134 and IL2RB
 TRAF1 antibody  >2 publications with CD134 and TRAF1
 TRAF5 antibody  >2 publications with CD134 and TRAF5
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
Diseases associated with anti-CD134 antibodyOrgans/Tissues associated with anti-CD134 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >294 publications with CD134 and Necrosis
 Immune System Diseases Antibodies  >122 publications with CD134 and Immune System Diseases
 Autoimmune Diseases Antibodies  >57 publications with CD134 and Autoimmune Diseases
 Disease Models, Animal Antibodies  >55 publications with CD134 and Disease Models, Animal
 Inflammation Antibodies  >49 publications with CD134 and Inflammation
 Lung Diseases Antibodies  >23 publications with CD134 and Lung Diseases
 Nervous System Diseases Antibodies  >23 publications with CD134 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >21 publications with CD134 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >21 publications with CD134 and Neoplasms, Experimental
 Brain Diseases Antibodies  >14 publications with CD134 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >338 publications with CD134 and Blood
 Lymph Node Antibodies  >47 publications with CD134 and Lymph Node
 Lung Antibodies  >23 publications with CD134 and Lung
 Skin Antibodies  >22 publications with CD134 and Skin
 Intestine Antibodies  >8 publications with CD134 and Intestine
 Kidney Antibodies  >6 publications with CD134 and Kidney
 Stomach Antibodies  >1 publications with CD134 and Stomach
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