O43678
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CD14
NCBI Official Synonym Full Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NCBI Protein Information
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; OTTHUMP00000159890; OTTHUMP00000223709; complex I B8 subunit; NADH-ubiquinone oxidoreductase subunit CI-B8
UniProt Protein Name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
UniProt Synonym Protein Names
Complex I-B8; CI-B8; NADH-ubiquinone oxidoreductase B8 subunit
UniProt Entry Name
NDUA2_HUMAN
NCBI Summary for NDUFA2
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.
UniProt Comments for NDUFA2
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subunit structure: Complex I is composed of 45 different subunits.
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Product References and Citations for anti-NDUFA2 antibody
1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD14 Section, Academic Press, New York, p. 169. 3. Hogg, N., S. MacDonald, M. Slusarenko, and P.C. Beverley. 1984. Immunol. 53:753. 4. Stocks, S.C., M. Albrechtsen, and M.A. Kerr. 1990. Biochem. J. 268:275.
Research Articles on NDUFA2
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Pathways associated with anti-NDUFA2 antibody
Diseases associated with anti-NDUFA2 antibody
Organs/Tissues associated with anti-NDUFA2 antibody
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