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anti-BSG antibody :: anti-Human CD147 (Neurothelin) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312130 anti-BSG antibody
Unit / Price
0.2 mg  /  $750 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD147 (Neurothelin) (BSG), Monoclonal Antibody

 Also Known As   

MAb to CD147

 Product Synonym Names    Monoclonal Antibody to Human CD147 (Neurothelin)
 Product Gene Name   

anti-BSG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (571325..583493). Location: 19p13.3
 3D Structure    ModBase 3D Structure for Q54A51
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MEM-M6/1
 Host    Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.
Source: Ascites
 Species Reactivity    Human
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 Specificity    CD147 (Neurothelin)
Recognizes human CD147. Reacts with an epitope in the N-terminal Ig domain (D1). Recognizes a 50-60 kDa glycoprotein also known as neurothelin and basigin. CD147 is expressed on peripheral blood cells and by endothelial cells. Expre
 Purity/Purification    Protein A chromatography
 Form/Format    Purified, Liquid
 Concentration    1mg/ml (OD280nm) (lot specific)
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 Immunogen    Soluble recombinant CD147Rg (extracellular region)
 Affinity Constant    1.91 x 10^10
 Buffer    PBS, pH 7.4
 Preservative    0.05% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short term, store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C. Avoid multiple freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BSG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-BSG antibody    Monoclonal Antibodies to Human CDs
 Applications Tested/Suitable for anti-BSG antibody   

Flow Cytometry, Western Blot

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NCBI/Uniprot data below describe general gene information for BSG. It may not necessarily be applicable to this product.
 NCBI GI #    31076333
 NCBI GeneID    682
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 UniProt Primary Accession #    Q54A51 [Other Products]
 UniProt Related Accession #    P35613; Q54A51 [Other Products]
 Molecular Weight    29,221 Da [Similar Products]
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 NCBI Official Full Name    CD147
 NCBI Official Synonym Full Names    basigin (Ok blood group)
 NCBI Official Symbol    BSG [Similar Products]
 NCBI Official Synonym Symbols   
M6; OK; 5F7; TCSF; CD147; EMMPRIN
[Similar Products]
 NCBI Protein Information    basigin; CD147 antigen; OK blood group antigen; collagenase stimulatory factor; leukocyte activation antigen M6; extracellular matrix metalloproteinase inducer; tumor cell-derived collagenase stimulatory factor
 UniProt Protein Name    Basigin (Ok blood group), isoform CRA_a
 Protein Family    Basigin
 UniProt Gene Name    hEMMPRIN [Similar Products]
 UniProt Synonym Gene Names    BSG [Similar Products]
 UniProt Entry Name    Q54A51_HUMAN
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 NCBI Summary for BSG    The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for BSG    BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi membrane; focal adhesion; membrane; mitochondrion; integral to plasma membrane; plasma membrane; melanosome; sarcolemma; lipid raft; acrosomal membrane

Molecular Function: mannose binding; protein binding

Biological Process: response to mercury ion; extracellular matrix disassembly; response to peptide hormone stimulus; cellular metabolic process; extracellular matrix organization and biogenesis; response to cAMP; cell surface receptor linked signal transduction; decidualization; blood coagulation; pyruvate metabolic process; leukocyte migration; embryo implantation; odontogenesis of dentine-containing teeth

Disease: Blood Group--ok
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Product References and Citations for anti-BSG antibody

   • Koch, C., et al., (1999), "T cell activation-associated epitopes of CD147 in regulation of the T cell response and their definition by antibody affinity and antigen density", International Immunology, 11(5): 777-786.
• Reimers, N.
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 Research Articles on BSG    1. study suggests EMMPRIN expression is important feature of malignant salivary gland tumors and can be used as biologic marker to characterize salivary gland tumors. EMMPRIN is also positive angiogenic factor in salivary gland tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BSG antibodyPathways associated with anti-BSG antibody
 Reference Product  PubMed Publications
 SLC16A3 antibody  >4 publications with BSG and SLC16A3
 MMP1 antibody  >4 publications with BSG and MMP1
 CAV1 antibody  >3 publications with BSG and CAV1
 SLC16A1 antibody  >1 publications with BSG and SLC16A1
 PPIL2 antibody  >1 publications with BSG and PPIL2
 Products by Pathway  Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies  Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
 Syndecan-1-mediated Signaling Events Pathway antibodies  Syndecan-1-mediated Signaling Events Pathway Diagram
Diseases associated with anti-BSG antibodyOrgans/Tissues associated with anti-BSG antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >221 publications with BSG and Neoplasms
 Adenocarcinoma Antibodies  >48 publications with BSG and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >46 publications with BSG and Cardiovascular Diseases
 Neoplasm Invasiveness Antibodies  >45 publications with BSG and Neoplasm Invasiveness
 Neuroectodermal Tumors Antibodies  >45 publications with BSG and Neuroectodermal Tumors
 Inflammation Antibodies  >38 publications with BSG and Inflammation
 Brain Neoplasms Antibodies  >36 publications with BSG and Brain Neoplasms
 Immune System Diseases Antibodies  >36 publications with BSG and Immune System Diseases
 Nervous System Neoplasms Antibodies  >36 publications with BSG and Nervous System Neoplasms
 Urogenital Neoplasms Antibodies  >28 publications with BSG and Urogenital Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >311 publications with BSG and Blood
 Brain Antibodies  >156 publications with BSG and Brain
 Vascular Antibodies  >79 publications with BSG and Vascular
 Nerve Antibodies  >49 publications with BSG and Nerve
 Muscle Antibodies  >39 publications with BSG and Muscle
 Liver Antibodies  >39 publications with BSG and Liver
 Eye Antibodies  >37 publications with BSG and Eye
 Lung Antibodies  >35 publications with BSG and Lung
 Embryonic Tissue Antibodies  >30 publications with BSG and Embryonic Tissue
 Bone Antibodies  >29 publications with BSG and Bone
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