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anti-CD40LG antibody :: Mouse anti-Human CD154, soluble Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS633272 anti-CD40LG antibody
Unit / Price
0.2 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD154, soluble (CD40LG), Monoclonal Antibody

 Also Known As   

CD154, soluble (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5)

 Product Synonym Names    Anti -CD154, soluble (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5)
 Product Gene Name   

anti-CD40LG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (135730281..135742549). Location: Xq26
 OMIM    300386
 3D Structure    ModBase 3D Structure for P29965
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9A158
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human CD154, a 32kD glycoprotein also known as CD40 ligand.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide.
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 Immunogen    Recombinant human soluble CD154 conjugated to BSA.
 Hybridoma    Spleen cells from immunized Balb/c mice were fused with cells of the myeloma Sp2/0 cell line.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CD40LG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD40LG antibody

   CD154 is a member of the TNF family of molecules. It binds to CD40 and acts as a co-stimulatory molecule by activating antigen presenting cells, such as B cells. While CD154 is mostly found expressed on activated T cells.
 Product Categories/Family for anti-CD40LG antibody    Antibodies; Abs to CD Markers
 Applications Tested/Suitable for anti-CD40LG antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-CD40LG antibody    Suitable for use in ELISA and Western Blot.
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NCBI/Uniprot data below describe general gene information for CD40LG. It may not necessarily be applicable to this product.
 NCBI GI #    4557433
 NCBI GeneID    959
 NCBI Accession #    NP_000065.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000074.2 [Other Products]
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 UniProt Primary Accession #    P29965 [Other Products]
 UniProt Related Accession #    P29965 [Other Products]
 Molecular Weight    29,274 Da [Similar Products]
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 NCBI Official Full Name    CD40 ligand
 NCBI Official Synonym Full Names    CD40 ligand
 NCBI Official Symbol    CD40LG [Similar Products]
 NCBI Official Synonym Symbols   
IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
[Similar Products]
 NCBI Protein Information    CD40 ligand; CD40-L; CD40 antigen ligand; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5
 UniProt Protein Name    CD40 ligand
 UniProt Synonym Protein Names   
T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5
 Protein Family    CD40 ligand
 UniProt Gene Name    CD40LG [Similar Products]
 UniProt Synonym Gene Names    CD40L; TNFSF5; TRAP; CD40-L; TRAP [Similar Products]
 UniProt Entry Name    CD40L_HUMAN
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 NCBI Summary for CD40LG    The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD40LG    CD40LG: Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: Xq26

Cellular Component: extracellular space; integral to plasma membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: cytokine activity; CD40 receptor binding; tumor necrosis factor receptor binding

Biological Process: B cell proliferation; platelet activation; regulation of immune response; leukocyte adhesion; positive regulation of interleukin-12 production; immunoglobulin secretion; B cell differentiation; isotype switching; inflammatory response; regulation of immunoglobulin secretion; negative regulation of apoptosis

Disease: Immunodeficiency With Hyper-igm, Type 1
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 Research Articles on CD40LG    1. A major part of central and effector memory CD8(+) T cells expresses CD40L, one key molecule for CD4(+) T-cell-mediated help.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD40LG antibodyPathways associated with anti-CD40LG antibody
 Reference Product  PubMed Publications
 CD40 antibody  >23 publications with CD40LG and CD40
 ICAM1 antibody  >3 publications with CD40LG and ICAM1
 CD86 antibody  >3 publications with CD40LG and CD86
 TRAF1 antibody  >2 publications with CD40LG and TRAF1
 RELA antibody  >1 publications with CD40LG and RELA
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
Diseases associated with anti-CD40LG antibodyOrgans/Tissues associated with anti-CD40LG antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with CD40LG and Inflammation
 Neoplasms Antibodies  >7 publications with CD40LG and Neoplasms
 Necrosis Antibodies  >6 publications with CD40LG and Necrosis
 Myocardial Infarction Antibodies  >3 publications with CD40LG and Myocardial Infarction
 IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 1 Antibodies  >3 publications with CD40LG and IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 1
 Myocardial Ischemia Antibodies  >3 publications with CD40LG and Myocardial Ischemia
 Cardiovascular Diseases Antibodies  >3 publications with CD40LG and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with CD40LG and Heart Diseases
 Kidney Diseases Antibodies  >2 publications with CD40LG and Kidney Diseases
 Hypersensitivity Antibodies  >2 publications with CD40LG and Hypersensitivity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with CD40LG and Blood
 Mixed Antibodies  >1 publications with CD40LG and Mixed
 Thymus Antibodies  >1 publications with CD40LG and Thymus
 Brain Antibodies  >1 publications with CD40LG and Brain
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