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anti-CD16 antibody :: Mouse anti-Human CD16 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530474 anti-CD16 antibody
Unit / Price
0.1 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD16, Monoclonal Antibody

 Also Known As   

CD16 antibody

 Product Synonym Names    Monoclonal CD16; Anti-CD16; CD-16; CD 16; FcgRIII; CD16 FcgRIII; CD16
 Product Gene Name   

anti-CD16 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146740
 3D Structure    ModBase 3D Structure for P08637
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3G8
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    > 95% pure
CD16 antibody was purified by Protein A chromatography.
 Form/Format    50mM Na3PO4, pH 7.5, with 100mM KCL, 150mM NaCl, and 0.5 mg/ml gentamycin sulfate.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    Human CD16 is a low affinity receptor for complexed IgG and occurs in two distinct forms, as a glycosyl phosphtidyl inositol (GPI) anchored protein in granulocytes, and as an integral membrane protein on NK cells and macrophages.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    CD16 antibody was raised in mouse using human polymorphonuclear leukocytes as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD16 antibody

   Mouse monoclonal CD16 antibody
 Product Categories/Family for anti-CD16 antibody    Immunology
 Applications Tested/Suitable for anti-CD16 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-CD16 antibody    FC: 5 ug/ml
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NCBI/Uniprot data below describe general gene information for CD16. It may not necessarily be applicable to this product.
 NCBI GI #    8176551
 NCBI GeneID    2214
 NCBI Accession #    AAB33925.2 [Other Products]
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 UniProt Primary Accession #    P08637 [Other Products]
 UniProt Secondary Accession #    Q53FJ0; Q53FL6; Q5EBR4; Q65ZM6; Q6PIJ0; A2N6W9 [Other Products]
 UniProt Related Accession #    P08637 [Other Products]
 Molecular Weight    29,089 Da
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 NCBI Official Full Name    CD16, partial
 NCBI Official Synonym Full Names    Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
 NCBI Official Symbol    FCGR3A [Similar Products]
 NCBI Official Synonym Symbols   
CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA
[Similar Products]
 NCBI Protein Information    low affinity immunoglobulin gamma Fc region receptor III-A
 UniProt Protein Name    Low affinity immunoglobulin gamma Fc region receptor III-A
 UniProt Synonym Protein Names   
CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
 Protein Family    CD160 antigen
 UniProt Gene Name    FCGR3A [Similar Products]
 UniProt Synonym Gene Names    CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa [Similar Products]
 UniProt Entry Name    FCG3A_HUMAN
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 NCBI Summary for CD16    This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD16    FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: IgG binding

Biological Process: regulation of immune response; innate immune response; immune response

Disease: Immunodeficiency 20
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 Research Articles on CD16    1. This meta-analysis demonstrates that FCGR3A V allele carriers show a better response to rituximab, and individuals carrying the IL-6 -174 C allele show a poorer response to anti-TNF therapy for rheumatoid arthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD16 antibodyPathways associated with anti-CD16 antibody
 Reference Product  PubMed Publications
 FCGR2A antibody  >72 publications with CD16 and FCGR2A
 FCGR2B antibody  >27 publications with CD16 and FCGR2B
 PIK3CA antibody  >2 publications with CD16 and PIK3CA
 SYK antibody  >2 publications with CD16 and SYK
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
Diseases associated with anti-CD16 antibodyOrgans/Tissues associated with anti-CD16 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >28 publications with CD16 and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >26 publications with CD16 and Lupus Erythematosus, Systemic
 Cardiovascular Diseases Antibodies  >23 publications with CD16 and Cardiovascular Diseases
 Inflammation Antibodies  >19 publications with CD16 and Inflammation
 Leukemia Antibodies  >14 publications with CD16 and Leukemia
 Breast Neoplasms Antibodies  >13 publications with CD16 and Breast Neoplasms
 Kidney Diseases Antibodies  >12 publications with CD16 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >11 publications with CD16 and Neoplasms, Experimental
 Hemorrhage Antibodies  >8 publications with CD16 and Hemorrhage
 Leukemia, Lymphoid Antibodies  >7 publications with CD16 and Leukemia, Lymphoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >166 publications with CD16 and Blood
 Kidney Antibodies  >10 publications with CD16 and Kidney
 Ovary Antibodies  >6 publications with CD16 and Ovary
 Lung Antibodies  >5 publications with CD16 and Lung
 Liver Antibodies  >4 publications with CD16 and Liver
 Brain Antibodies  >3 publications with CD16 and Brain
 Intestine Antibodies  >1 publications with CD16 and Intestine
 Thyroid Antibodies  >1 publications with CD16 and Thyroid
 Spleen Antibodies  >1 publications with CD16 and Spleen
 Stomach Antibodies  >1 publications with CD16 and Stomach
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