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anti-CD160 antibody :: Rat CD160 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS832170
Flow Cytometry (FC/FACS)
Unit / Price
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $395 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD160, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD160 antibody (PE)

 Product Synonym Names    Monoclonal CD160; Anti-CD160; NK1; CD-160; CD 160; CD160; NK28; BY55
 Product Gene Name   

anti-CD160 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604463
 3D Structure    ModBase 3D Structure for O95971
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 Clonality    Monoclonal
 Isotype    IgG2a kappa
 Clone Number    CNX46-3
 Host    Rat
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 Specificity    Human
 Form/Format    Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
 Concentration    200 ug/ml (lot specific)
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 Biological Significance    CD160 is a glycosylphosphatidylinositol -anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all iIELs, NKT cells, most TCRgamma delta T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160. In human, CD160 mAb cross-linking triggers TNF alpha, IFNgamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.
 Tag/Conjugate    PE
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. Protect from light.
 Other Notes    Small volumes of anti-CD160 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD160 antibody

   Rat monoclonal CD160 antibody (PE)
 Product Categories/Family for anti-CD160 antibody    Immunology; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD160 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-CD160 antibody    FC: <= 0.125 ug/test

A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
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 Flow Cytometry (FC/FACS) of anti-CD160 antibody    Staining of C57BL/6 splenocytes with CD3 antibody (FITC), NK1.1 antibody (APC), and 0.5 ug of CD160 antibody (PE). The histogram (right) demonstrates staining of CD160 on NK1.1+CD3- cells (red histogram) and NK1.1+CD3+ cells (black histogram), as gated in the dot plot (left).
anti-CD160 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for CD160. It may not necessarily be applicable to this product.
 NCBI GI #    5901910
 NCBI GeneID    11126
 NCBI Accession #    NP_008984.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007053.3 [Other Products]
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 UniProt Primary Accession #    O95971 [Other Products]
 UniProt Related Accession #    O95971 [Other Products]
 Molecular Weight    19,810 Da
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 NCBI Official Full Name    CD160 antigen
 NCBI Official Synonym Full Names    CD160 molecule
 NCBI Official Symbol    CD160 [Similar Products]
 NCBI Official Synonym Symbols   
NK1; BY55; NK28
[Similar Products]
 NCBI Protein Information    CD160 antigen
 UniProt Protein Name    CD160 antigen
 UniProt Synonym Protein Names   
Natural killer cell receptor BY55; CD_antigen: CD160
 Protein Family    CD160 antigen
 UniProt Gene Name    CD160 [Similar Products]
 UniProt Synonym Gene Names    BY55 [Similar Products]
 UniProt Entry Name    BY55_HUMAN
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 NCBI Summary for CD160    CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD160    Receptor showing broad specificity for both classical and non-classical MHC class I molecules.
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 Research Articles on CD160    1. A population of CD4+ CD160+ T lymphocytes was identified in circulating cutaneous T cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD160 antibodyDiseases associated with anti-CD160 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >32 publications with CD160 and Immune System Diseases
 Necrosis Antibodies  >32 publications with CD160 and Necrosis
 Death Antibodies  >22 publications with CD160 and Death
 Inflammation Antibodies  >16 publications with CD160 and Inflammation
 Liver Diseases Antibodies  >4 publications with CD160 and Liver Diseases
 Metaplasia Antibodies  >2 publications with CD160 and Metaplasia
 Hypersensitivity Antibodies  >1 publications with CD160 and Hypersensitivity
 Lung Diseases Antibodies  >1 publications with CD160 and Lung Diseases
 Atherosclerosis Antibodies  >1 publications with CD160 and Atherosclerosis
 Dermatitis, Contact Antibodies  >1 publications with CD160 and Dermatitis, Contact
Organs/Tissues associated with anti-CD160 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with CD160 and Kidney
 Lung Antibodies  >3 publications with CD160 and Lung
 Liver Antibodies  >3 publications with CD160 and Liver
 Embryonic Tissue Antibodies  >1 publications with CD160 and Embryonic Tissue
 Brain Antibodies  >1 publications with CD160 and Brain
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