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anti-CD169 antibody :: Mouse CD169 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215902 anti-CD169 antibody
Unit / Price
0.1 mg  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD169, Monoclonal Antibody

 Also Known As   

MOUSE ANTI PIG CD169:FITC

 Product Gene Name   

anti-CD169 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for A7LCJ3
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3B11/11
 Host    Mouse
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Pig
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD169 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD169 antibody

   Mouse anti Pig CD169, clone 3B11/11 Is specific for porcine CD169, also known as sialoadhesin or Siglec-1, a member of the sialic acid binding immunoglobulin-like lectin (Siglec) family. CD169 was originally identified in mice and identified as the sialic acid dependent Sheep erythrocyte receptor (Crocker et al.1986). CD169 has subsequently been identified in rat (van den Berg et al. 1992), human (Mucklow et al. 1995) and pig (Vanderheijden et al. 2003). Mouse anti Porcine CD169, clone 3B1/11 was originally raised as part of a panel of anti porcine macrophage monoclonal antibodies raised against isolated porcine alveolar macrophages (Bullido et al. 1997). Immunohistochemical analysis indicated restriction to macrophage populations mainly in the spleen, lymph nodes, liver and Peyer's patches. Originally described as a non phagocytic intercellular adhesion receptor, work on porcine CD169 indicated that it may play a role as a viral adhesion receptor (Delputte et al. 2006) and as a targeted receptor for the delivery of toxins and antigens (Delputte et al. 2011). Mouse anti pig CD169, clone 3B11/11 detects a band of approximately 190 kDa in alveolar macrophage extracts under non-reducing conditions (Revilla et al).
 Applications Tested/Suitable for anti-CD169 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD169 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to 1x106 cells in 100ul.
Flow Cytometry: Maximum Dilution: Neat
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NCBI/Uniprot data below describe general gene information for CD169. It may not necessarily be applicable to this product.
 NCBI GI #    50979305
 NCBI GeneID    397623
 NCBI Accession #    NP_999511.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_214346.1 [Other Products]
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 UniProt Primary Accession #    A7LCJ3 [Other Products]
 UniProt Secondary Accession #    Q2VF24; Q7YRQ7 [Other Products]
 UniProt Related Accession #    A7LCJ3 [Other Products]
 Molecular Weight    184,912 Da
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 NCBI Official Full Name    sialoadhesin
 NCBI Official Symbol    SIGLEC-1 [Similar Products]
 NCBI Official Synonym Symbols   
SA; SN; pSn; p210; SIGLEC1
[Similar Products]
 NCBI Protein Information    sialoadhesin; Sialic acid-binding Ig-like lectin 1
 UniProt Protein Name    Sialoadhesin
 UniProt Synonym Protein Names   
Sialic acid-binding Ig-like lectin 1; Siglec-1; p210
 UniProt Gene Name    SIGLEC1 [Similar Products]
 UniProt Synonym Gene Names    SA; SN; pSn; Siglec-1 [Similar Products]
 UniProt Entry Name    SN_PIG
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 UniProt Comments for CD169    Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis (). Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process.
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 Research Articles on CD169    1. Fusion protein of sialoadhesin and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD169 antibodyOrgans/Tissues associated with anti-CD169 antibody
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Lymph Antibodies  >36 publications with CD169 and Lymph
 Embryonic Tissue Antibodies  >4 publications with CD169 and Embryonic Tissue
 Thyroid Antibodies  >2 publications with CD169 and Thyroid
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