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anti-CD177 antibody :: Mouse CD177 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245155
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD177, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone MEM-166] (IgG1) to Human CD177

 Product Synonym Names    Anti-CD177 Antibody (clone MEM-166) IHC-plus; CD177; CD177 molecule; CD177 antigen; Cell surface receptor; HNA-2a; HNA2A; NB1; PRV-1; Polycythemia rubra vera 1; PRV1; NB1 glycoprotein; NB1 GP; Human CD177
 Product Gene Name   

anti-CD177 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162860
 3D Structure    ModBase 3D Structure for Q8N6Q3
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MEM-166
 Host    Mouse
 Species Reactivity    Human, Monkey
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 Specificity    Human granulocytes
 Purity/Purification    Affinity Purified
 Form/Format    Phosphate-buffered solution, pH 7.2, 0.09% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Cells.
 Immunogen    CD177 antibody was raised against cells.
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 Preparation and Storage    +4 degree C. Store undiluted.
 Other Notes    Small volumes of anti-CD177 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD177 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

 Application Notes for anti-CD177 antibody    Flo (1 ug/10E6 cells), IHC-P (10 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CD177 antibody    Anti-CD177 antibody IHC of human intravascular neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-CD177 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-CD177 antibody    Human peripheral blood granulocytes stained with purified MEM-166, followed by anti-mouse IgG FITC
anti-CD177 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for CD177. It may not necessarily be applicable to this product.
 NCBI GI #    110735433
 NCBI GeneID    57126
 NCBI Accession #    NP_065139.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_020406.3 [Other Products]
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 UniProt Primary Accession #    Q8N6Q3 [Other Products]
 UniProt Secondary Accession #    Q711Q2; Q8NCV9; Q96QH1; Q9HDA5 [Other Products]
 UniProt Related Accession #    Q8N6Q3 [Other Products]
 Molecular Weight    15,683 Da
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 NCBI Official Full Name    CD177 antigen
 NCBI Official Synonym Full Names    CD177 molecule
 NCBI Official Symbol    CD177 [Similar Products]
 NCBI Official Synonym Symbols   
NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP
[Similar Products]
 NCBI Protein Information    CD177 antigen; NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1
 UniProt Protein Name    CD177 antigen
 UniProt Synonym Protein Names   
Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD_antigen: CD177
 Protein Family    CD177 antigen
 UniProt Gene Name    CD177 [Similar Products]
 UniProt Synonym Gene Names    NB1; PRV1; HNA-2a; NB1 GP; PRV-1 [Similar Products]
 UniProt Entry Name    CD177_HUMAN
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 NCBI Summary for CD177    This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
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 UniProt Comments for CD177    CD177: Induced by CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET). 3 isoforms of the human protein are produced by alternative splicing

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: plasma membrane

Biological Process: blood coagulation; leukocyte migration
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 Research Articles on CD177    1. This is the first report showing a prognostic correlation between CD177 expression and solid tumor behavior.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD177 antibodyPathways associated with anti-CD177 antibody
 Reference Product  PubMed Publications
 JAK2 antibody  >30 publications with CD177 and JAK2
 MPL antibody  >19 publications with CD177 and MPL
 EPO antibody  >6 publications with CD177 and EPO
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CD177 antibodyOrgans/Tissues associated with anti-CD177 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >22 publications with CD177 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >20 publications with CD177 and Vascular Diseases
 Lung Diseases Antibodies  >18 publications with CD177 and Lung Diseases
 Respiratory Tract Diseases Antibodies  >17 publications with CD177 and Respiratory Tract Diseases
 Lung Injury Antibodies  >15 publications with CD177 and Lung Injury
 Inflammation Antibodies  >12 publications with CD177 and Inflammation
 Necrosis Antibodies  >6 publications with CD177 and Necrosis
 Disease Models, Animal Antibodies  >5 publications with CD177 and Disease Models, Animal
 Anemia Antibodies  >5 publications with CD177 and Anemia
 Myelodysplastic Syndromes Antibodies  >5 publications with CD177 and Myelodysplastic Syndromes
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >136 publications with CD177 and Blood
 Lung Antibodies  >22 publications with CD177 and Lung
 Skin Antibodies  >4 publications with CD177 and Skin
 Prostate Antibodies  >3 publications with CD177 and Prostate
 Stomach Antibodies  >2 publications with CD177 and Stomach
 Embryonic Tissue Antibodies  >2 publications with CD177 and Embryonic Tissue
 Spleen Antibodies  >1 publications with CD177 and Spleen
 Brain Antibodies  >1 publications with CD177 and Brain
 Placenta Antibodies  >1 publications with CD177 and Placenta
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