NP_000202.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
integrin beta-2 isoform 1
NCBI Official Synonym Full Names
integrin subunit beta 2
NCBI Official Synonym Symbols
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1 [Similar Products]
NCBI Protein Information
integrin beta-2
UniProt Protein Name
Integrin beta-2
UniProt Synonym Protein Names
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
UniProt Synonym Gene Names
UniProt Entry Name
ITB2_HUMAN
NCBI Summary for ITGB2
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for ITGB2
ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cell surface; membrane; plasma membrane; receptor complex
Molecular Function: cell adhesion molecule binding; glycoprotein binding; ICAM-3 receptor activity; protein binding; protein kinase binding
Biological Process: cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte adhesion; leukocyte migration; neutrophil chemotaxis; receptor clustering; receptor internalization; regulation of immune response; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway
Disease: Leukocyte Adhesion Deficiency, Type I
Product References and Citations for anti-ITGB2 antibody
Leucocyte Typing III, (ed. McMichael AJ et. al.), Oxford Univ. Press, Oxford, 1987
Research Articles on ITGB2
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Products associated with anti-ITGB2 antibody
Pathways associated with anti-ITGB2 antibody
Diseases associated with anti-ITGB2 antibody
Organs/Tissues associated with anti-ITGB2 antibody
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