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anti-CD18 antibody :: Mouse CD18 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS212479
Unit / Price
0.2 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD18, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD18 (ACTIVATION EPITOPE)

 Product Gene Name   

anti-CD18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116920
 3D Structure    ModBase 3D Structure for P05107
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MEM-148
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Peripheral blood mononuclear cells.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD18 antibody

   Mouse anti Human CD18 (Activation Epitope) antibody, clone MEM-148 recognizes an epitope on the human CD18 molecule that is hidden in the CD11/CD18 heterodimer on resting cells. Clone MEM-148 binds very weakly to resting peripheral blood leukocytes and strongly to all leukocytes upon cellular activation. The epitope recognized by Mouse anti Human CD18 (Activation Epitope) antibody, clone MEM-148 is also exposed during dissociation of the CD11/CD18 by low pH.
 Applications Tested/Suitable for anti-CD18 antibody   

Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-CD18 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Western Blotting: Maximum Dilution: Non-reducing conditions
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 Testing Data of anti-CD18 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD18 (Activation Epitope):Biotin (MBS210392)
anti-CD18 antibody Testing Data image
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 Testing Data of anti-CD18 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD86 (Activation Epitope): Azide free (MBS210203)
anti-CD18 antibody Testing Data image
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 Testing Data of anti-CD18 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human CD18 (ACT EPITOPE)
anti-CD18 antibody Testing Data image
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 Testing Data of anti-CD18 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human CD18 (Activation Epitope):RPE (MBS213718)
anti-CD18 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD18. It may not necessarily be applicable to this product.
 NCBI GI #    89191865
 NCBI GeneID    3689
 NCBI Accession #    NP_000202.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000211.3 [Other Products]
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 UniProt Primary Accession #    P05107 [Other Products]
 UniProt Secondary Accession #    Q16418; Q53HS5; Q9UD72; B3KTS8; D3DSM1 [Other Products]
 UniProt Related Accession #    P05107 [Other Products]
 Molecular Weight    84,782 Da
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 NCBI Official Full Name    integrin beta-2
 NCBI Official Synonym Full Names    integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 NCBI Official Symbol    ITGB2 [Similar Products]
 NCBI Official Synonym Symbols   
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
[Similar Products]
 NCBI Protein Information    integrin beta-2; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); complement receptor C3 beta-subunit; integrin beta chain, beta 2; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
 UniProt Protein Name    Integrin beta-2
 UniProt Synonym Protein Names   
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
 Protein Family    CD180 antigen
 UniProt Gene Name    ITGB2 [Similar Products]
 UniProt Synonym Gene Names    CD18; MFI7 [Similar Products]
 UniProt Entry Name    ITB2_HUMAN
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 NCBI Summary for CD18    This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
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 UniProt Comments for CD18    ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Cell surface; Receptor, misc.

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex; vesicle; lipid raft

Molecular Function: protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cell-cell signaling; cellular extravasation; cell adhesion; inflammatory response; toll-like receptor 4 signaling pathway; regulation of peptidyl-tyrosine phosphorylation; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; endothelial cell migration; innate immune response; blood coagulation; leukocyte migration

Disease: Leukocyte Adhesion Deficiency, Type I
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 Research Articles on CD18    1. overview of the adaptor proteins involved in the intracellular signaling cascades by which LFA-1 regulates T-cell motility and immune responses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD18 antibodyPathways associated with anti-CD18 antibody
 Reference Product  PubMed Publications
 ITGAM antibody  >1648 publications with CD18 and ITGAM
 ITGAL antibody  >1095 publications with CD18 and ITGAL
 ICAM1 antibody  >880 publications with CD18 and ICAM1
 ITGAX antibody  >410 publications with CD18 and ITGAX
 ICAM2 antibody  >58 publications with CD18 and ICAM2
 ICAM3 antibody  >48 publications with CD18 and ICAM3
 ITGAD antibody  >18 publications with CD18 and ITGAD
 JAM3 antibody  >6 publications with CD18 and JAM3
 ITGA7 antibody  >1 publications with CD18 and ITGA7
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
Diseases associated with anti-CD18 antibodyOrgans/Tissues associated with anti-CD18 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >927 publications with CD18 and Inflammation
 Necrosis Antibodies  >618 publications with CD18 and Necrosis
 Cardiovascular Diseases Antibodies  >407 publications with CD18 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >237 publications with CD18 and Disease Models, Animal
 Lung Diseases Antibodies  >221 publications with CD18 and Lung Diseases
 Leukocyte-Adhesion Deficiency Syndrome Antibodies  >167 publications with CD18 and Leukocyte-Adhesion Deficiency Syndrome
 Heart Diseases Antibodies  >130 publications with CD18 and Heart Diseases
 Leukocyte Disorders Antibodies  >115 publications with CD18 and Leukocyte Disorders
 Hypersensitivity Antibodies  >113 publications with CD18 and Hypersensitivity
 Atherosclerosis Antibodies  >74 publications with CD18 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3739 publications with CD18 and Blood
 Lung Antibodies  >376 publications with CD18 and Lung
 Bone Antibodies  >294 publications with CD18 and Bone
 Bone Marrow Antibodies  >264 publications with CD18 and Bone Marrow
 Heart Antibodies  >187 publications with CD18 and Heart
 Muscle Antibodies  >163 publications with CD18 and Muscle
 Liver Antibodies  >128 publications with CD18 and Liver
 Embryonic Tissue Antibodies  >123 publications with CD18 and Embryonic Tissue
 Brain Antibodies  >105 publications with CD18 and Brain
 Spleen Antibodies  >104 publications with CD18 and Spleen
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