View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-CD19 antibody :: Rabbit anti-Human CD19 Monoclonal Antibody Catalog # MBS2544305 Unit / Price 0.06 mL / $260 +1 FREE 8GB USB 0.12 mL / $380 +1 FREE 8GB USB 0.2 mL / $560 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name CD19, Monoclonal Antibody Full Product Name Rabbit anti Human CD19 Monoclonal Antibody Product Gene Name anti-CD19 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM M21097 mRNA Clonality Monoclonal Isotype IgG Host Rabbit Species Reactivity Human Immunogen Recombinant Human CD19 protein Buffer 0.2 mum filtered solution in PBS with 5% trehalose Preparation and Storage This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-CD19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-CD19 antibody The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell coreceptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg. Applications Tested/Suitable for anti-CD19 antibody Immunohistochemistry (IHC) Paraffin Application Notes for anti-CD19 antibody IHC-P: 1-10 mug/mL TOP NCBI/Uniprot data below describe general gene information for CD19. It may not necessarily be applicable to this product. NCBI GI # 180034 NCBI GeneID 930 UniProt Secondary Accession # Q96S68; Q9BRD6; A0N0P9; F5H635[Other Products] UniProt Related Accession # P15391[Other Products] Molecular Weight 61,200 Da TOP NCBI Official Full Name CD19 NCBI Official Synonym Full Names CD19 molecule NCBI Official Symbol CD19 [Similar Products] NCBI Official Synonym Symbols B4; CVID3 [Similar Products] NCBI Protein Information B-lymphocyte antigen CD19 UniProt Protein Name B-lymphocyte antigen CD19 UniProt Synonym Protein Names B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19 Protein Family B-lymphocyte antigen UniProt Gene Name CD19 [Similar Products] UniProt Entry Name CD19_HUMAN TOP NCBI Summary for CD19 Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008] TOP UniProt Comments for CD19 CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Protein type: Cell surface; Membrane protein, integralChromosomal Location of Human Ortholog: 16p11.2Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane; protein complexMolecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; receptor signaling protein activityBiological Process: B cell receptor signaling pathway; cell surface receptor linked signal transduction; cellular defense response; phosphoinositide-mediated signaling; regulation of immune response; regulation of phosphoinositide 3-kinase cascadeDisease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3 Research Articles on CD19 1. The frequencies of CD19+CD24hiCD38hi B-regulatory lymphocyte were significantly increased in children with beta-thalassemia. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-CD19 antibody Reference Product PubMed Publications CD22 antibody >660 publications with CD19 and CD22 CD79A antibody >172 publications with CD19 and CD79A CD79B antibody >120 publications with CD19 and CD79B CD81 antibody >117 publications with CD19 and CD81 CR2 antibody >79 publications with CD19 and CR2 LYN antibody >65 publications with CD19 and LYN SYK antibody >54 publications with CD19 and SYK VAV1 antibody >15 publications with CD19 and VAV1 PIK3R1 antibody >3 publications with CD19 and PIK3R1 Pathways associated with anti-CD19 antibody Products by Pathway Pathway Diagram Adaptive Immune System Pathway antibodies Adaptive Immune System Pathway Diagram Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram BCR Signaling Pathway antibodies BCR Signaling Pathway Diagram Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram DAP12 Interactions Pathway antibodies DAP12 Interactions Pathway Diagram DAP12 Signaling Pathway antibodies DAP12 Signaling Pathway Diagram Disease Pathway antibodies Disease Pathway Diagram Diseases associated with anti-CD19 antibody Disease Name Pubmed Publications Cardiovascular Diseases Antibodies >497 publications with CD19 and Cardiovascular Diseases Vascular Diseases Antibodies >470 publications with CD19 and Vascular Diseases Inflammation Antibodies >454 publications with CD19 and Inflammation Necrosis Antibodies >366 publications with CD19 and Necrosis Death Antibodies >318 publications with CD19 and Death Lung Diseases Antibodies >238 publications with CD19 and Lung Diseases Liver Diseases Antibodies >189 publications with CD19 and Liver Diseases Kidney Diseases Antibodies >161 publications with CD19 and Kidney Diseases Cell Transformation, Neoplastic Antibodies >142 publications with CD19 and Cell Transformation, Neoplastic Common Variable Immunodeficiency Antibodies >98 publications with CD19 and Common Variable Immunodeficiency Organs/Tissues associated with anti-CD19 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >7066 publications with CD19 and Blood Bone Marrow Antibodies >1918 publications with CD19 and Bone Marrow Spleen Antibodies >659 publications with CD19 and Spleen Lymph Node Antibodies >526 publications with CD19 and Lymph Node Lymph Antibodies >471 publications with CD19 and Lymph Lung Antibodies >251 publications with CD19 and Lung Thymus Antibodies >186 publications with CD19 and Thymus Brain Antibodies >163 publications with CD19 and Brain Tonsil Antibodies >129 publications with CD19 and Tonsil Intestine Antibodies >114 publications with CD19 and Intestine TOP