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anti-CD19 antibody :: Mouse anti-Mouse CD19 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673250 anti-CD19 antibody
Unit / Price
0.1 mg  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD19, Monoclonal Antibody

 Also Known As   

Mouse Anti-Mouse CD19-PE

 Product Synonym Names    Mouse Anti-Mouse CD19 - Phycoerythrin-Labeled; Mouse Anti-Mouse CD19
 Product Gene Name   

anti-CD19 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (28943260..28950668). Location: 16p11.2
 OMIM    107265
 3D Structure    ModBase 3D Structure for P15391
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 Clonality    Monoclonal
 Isotype    Mouse (129 x C57BL/6) IgA kappa
 Clone Number    MB19-1
 Host    Mouse
 Species Reactivity    Mouse
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 Specificity    CD19 B cell differentiation antigen, Mr 95 kDa
CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220^+/CD43^+/HSA^+) through fully differentiated B cell stages. ^1-7 Terminally differentiated plasma cells do not express CD19. ^1 In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. ^3, 4 All splenic and peritoneal IgM^+ cells of both B-1 and B-2 lineages are CD19^+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. ^1, 7 Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. ^7
 Form/Format    R - phycoerythrin (R - PE) Conjugate
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 Immunogen    CD19^+ mouse pre-B cell line, 300.19
 Characterization    To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) and allophycocyanin (APC) conjugates are supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD), R-phycoerythrin-Cyanine 5.5 (R-PE-CY 5.5), Allophycocyanin-Cyanine 5.5 (APC-CY 5.5), and Allophycocyanin- Cyanine 7 (APC-CY 7) conjugates are supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Protect conjugated forms from light. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-CD19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD19 antibody   

Flow Cytometry; Immunoprecipitation

 Application Notes for anti-CD19 antibody    Flow Cytometry Suggested Dilution: <= 0.2 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for CD19. It may not necessarily be applicable to this product.
 NCBI GI #    901823
 NCBI GeneID    930
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 UniProt Primary Accession #    P15391 [Other Products]
 UniProt Secondary Accession #    Q96S68; Q9BRD6; A0N0P9 [Other Products]
 UniProt Related Accession #    P15391; Q6ZNU2; Q71UW0 [Other Products]
 Molecular Weight    61,128 Da [Similar Products]
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 NCBI Official Full Name    CD19
 NCBI Official Synonym Full Names    CD19 molecule
 NCBI Official Symbol    CD19 [Similar Products]
 NCBI Official Synonym Symbols   
B4; CVID3; MGC12802
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD19; OTTHUMP00000122551; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
 UniProt Protein Name    B-lymphocyte antigen CD19
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12
 Protein Family    B-lymphocyte antigen
 UniProt Gene Name    CD19 [Similar Products]
 UniProt Entry Name    CD19_HUMAN
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 NCBI Summary for CD19    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq]
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 UniProt Comments for CD19    Function: Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Subunit structure: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Ref.10 Ref.11 Ref.12

Involvement in disease: Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [

MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Ref.13

Sequence similarities: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Sequence caution: The sequence AAA35533.1 differs from that shown. Reason: Frameshift at position 396.
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Product References and Citations for anti-CD19 antibody

   1. Sato, S., N. Ono, D.A. Steeber, D.S. Pisetsky, and T.F. Tedder. 1996. J. Immunol. 157:4371-4378.
2. Krop, I., A.R. Fougerolles, R.R. Hardy, M. Allison, M.S. Schlissel, and D.T. Fearon. 1996. Eur. J. Immunol. 26:238.
3. Krop, I., A.L. Shaffer, D.T. Fearon, and M.S. Schlissel. 1996. J. Immunol. 157:48.
4. Fearon, D.T. 1993. Curr. Opin. in Immunol. 5:341.
5. Tedder, T.F., L.-J. Zhou, and P. Engel. 1994. Immunol. Today 15:437.
6. Rickert, R.C., K. Rajewsky, and J. Roes. 1995. Nature 376:352.
7. Engel, P., L.-J. Zhou, D.C. Ord, S. Sato, B. Koller, and T.F. Tedder. 1995. Immunity 3:39.
8. Rolink, A., E. ten Boekel, F. Melchers, D.T. Fearon, I. Krop, and J. Andersson. 1996. J. Exp. Med. 183:187.
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 Research Articles on CD19    1. CD23 and CD19 are important factors that associated with serum total IgE in the pathogenesis of allergic rhinitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD19 antibodyPathways associated with anti-CD19 antibody
 Reference Product  PubMed Publications
 CD22 antibody  >540 publications with CD19 and CD22
 CD79A antibody  >121 publications with CD19 and CD79A
 CD79B antibody  >90 publications with CD19 and CD79B
 CD81 antibody  >84 publications with CD19 and CD81
 CD9 antibody  >75 publications with CD19 and CD9
 CR2 antibody  >72 publications with CD19 and CR2
 LYN antibody  >53 publications with CD19 and LYN
 SYK antibody  >38 publications with CD19 and SYK
 BTK antibody  >35 publications with CD19 and BTK
 VAV1 antibody  >13 publications with CD19 and VAV1
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-CD19 antibodyOrgans/Tissues associated with anti-CD19 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2577 publications with CD19 and Neoplasms
 Lung Diseases Antibodies  >167 publications with CD19 and Lung Diseases
 Hypersensitivity Antibodies  >146 publications with CD19 and Hypersensitivity
 Arthritis, Rheumatoid Antibodies  >145 publications with CD19 and Arthritis, Rheumatoid
 Agammaglobulinemia Antibodies  >72 publications with CD19 and Agammaglobulinemia
 Common Variable Immunodeficiency Antibodies  >67 publications with CD19 and Common Variable Immunodeficiency
 Asthma Antibodies  >61 publications with CD19 and Asthma
 Pneumonia Antibodies  >58 publications with CD19 and Pneumonia
 Blood Coagulation Disorders Antibodies  >44 publications with CD19 and Blood Coagulation Disorders
 Liver Neoplasms Antibodies  >41 publications with CD19 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5063 publications with CD19 and Blood
 Bone Marrow Antibodies  >1451 publications with CD19 and Bone Marrow
 Spleen Antibodies  >439 publications with CD19 and Spleen
 Lymph Node Antibodies  >387 publications with CD19 and Lymph Node
 Lymph Antibodies  >343 publications with CD19 and Lymph
 Lung Antibodies  >171 publications with CD19 and Lung
 Thymus Antibodies  >152 publications with CD19 and Thymus
 Tonsil Antibodies  >104 publications with CD19 and Tonsil
 Brain Antibodies  >86 publications with CD19 and Brain
 Intestine Antibodies  >84 publications with CD19 and Intestine
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