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anti-CD1A antibody :: Rabbit CD1a/HTA1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380303
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD1a/HTA1, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD1a/HTA1 (Mature Langerhans Cells Marker)

 Product Synonym Names    Cortical thymocyte antigen CD1A; Epidermal dendritic cell marker CD1a antibody; FCB6; HTA1; T cell surface antigen T6 / Leu 6; T-Cell Surface Glycoprotein CD1A
 Product Gene Name   

anti-CD1A antibody

[Similar Products]
 Product Synonym Gene Name    HTA1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P06126
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    C1A/1506R
 Host    Rabbit
 Species Reactivity    Human. Others not known.
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 Specificity    At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa). 
 Form/Format    200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant full-length human CD1a protein
 Cellular Localization    Cell Surface
 Hu-chromosome Location    1q23.1
 Positive Control    MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-CD1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD1A antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-CD1A antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-CD1A antibody    Formalin-fixed, paraffin-embedded human Skin stained with CD1a Rabbit Recombinant Monoclonal Antibody (C1A/1506R).
anti-CD1A antibody Immunohistochemistry (IHC) (IHC) image
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 SDS-Page of anti-CD1A antibody    SDS-PAGE Analysis of Purified CD1a Rabbit Recombinant Monoclonal Antibody (C1A/1506R).
anti-CD1A antibody SDS-Page image
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NCBI/Uniprot data below describe general gene information for CD1A. It may not necessarily be applicable to this product.
 NCBI GI #    1002167153
 NCBI GeneID    909
 NCBI Accession #    NP_001307581.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001320652.1 [Other Products]
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 UniProt Primary Accession #    P06126 [Other Products]
 UniProt Secondary Accession #    Q13962; Q5TDJ8; Q9UMM4; Q9Y5M5; D3DVD7 [Other Products]
 UniProt Related Accession #    P06126 [Other Products]
 Molecular Weight    49kDa
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 NCBI Official Full Name    T-cell surface glycoprotein CD1a isoform 2
 NCBI Official Synonym Full Names    CD1a molecule
 NCBI Official Symbol    CD1A [Similar Products]
 NCBI Official Synonym Symbols   
R4; T6; CD1; FCB6; HTA1
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD1a
 UniProt Protein Name    T-cell surface glycoprotein CD1a
 UniProt Synonym Protein Names   
T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a
 Protein Family    T-cell surface glycoprotein
 UniProt Gene Name    CD1A [Similar Products]
 UniProt Synonym Gene Names    hTa1 thymocyte antigen [Similar Products]
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 NCBI Summary for CD1A    This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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 UniProt Comments for CD1A    Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
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Product References and Citations for anti-CD1A antibody

   Cassaday, RD.et al.2007. Clin. Cancer Res. 13: 540-549. Matsuda, A.et al.2009. Invest. Ophthalmol. Vis. Sci. 50: 2871-2877. Gulubova, M.et al.2008. Clin. Exp. Metastasis. 25: 777-785. McNally, AK.et al.2011. Exp. Mol. Pathol. 91: 673-681.
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 Research Articles on CD1A    1. In this review, authors summarize the current knowledge about CD1 proteins, their structures, lipid-binding profiles, and roles in immunity, and evaluate the role of CD1 proteins in eliciting humoral immune response
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD1A antibodyPathways associated with anti-CD1A antibody
 Reference Product  PubMed Publications
 CD83 antibody  >532 publications with CD1A and CD83
 CD207 antibody  >124 publications with CD1A and CD207
 KIRREL antibody  >1 publications with CD1A and KIRREL
 B2M antibody  >1 publications with CD1A and B2M
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with anti-CD1A antibodyOrgans/Tissues associated with anti-CD1A antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >406 publications with CD1A and Lung Diseases
 Necrosis Antibodies  >334 publications with CD1A and Necrosis
 Inflammation Antibodies  >232 publications with CD1A and Inflammation
 Cardiovascular Diseases Antibodies  >79 publications with CD1A and Cardiovascular Diseases
 Liver Diseases Antibodies  >68 publications with CD1A and Liver Diseases
 Fibrosis Antibodies  >65 publications with CD1A and Fibrosis
 Death Antibodies  >62 publications with CD1A and Death
 Hyperplasia Antibodies  >62 publications with CD1A and Hyperplasia
 Lung Neoplasms Antibodies  >47 publications with CD1A and Lung Neoplasms
 Breast Neoplasms Antibodies  >47 publications with CD1A and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1615 publications with CD1A and Blood
 Skin Antibodies  >970 publications with CD1A and Skin
 Lymph Node Antibodies  >309 publications with CD1A and Lymph Node
 Lung Antibodies  >181 publications with CD1A and Lung
 Thymus Antibodies  >120 publications with CD1A and Thymus
 Brain Antibodies  >65 publications with CD1A and Brain
 Heart Antibodies  >35 publications with CD1A and Heart
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