NP_001754.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,077 Da
NCBI Official Full Name
T-cell surface glycoprotein CD1a
NCBI Official Synonym Full Names
CD1a molecule
NCBI Protein Information
T-cell surface glycoprotein CD1a; CD1A antigen, a polypeptide; T-cell surface antigen T6/Leu-6; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; hTa1 thymocyte antigen
UniProt Protein Name
T-cell surface glycoprotein CD1a
UniProt Synonym Protein Names
T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a
UniProt Synonym Gene Names
UniProt Entry Name
CD1A_HUMAN
NCBI Summary for CD1a
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for CD1a
CD1A: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: integral to plasma membrane; plasma membrane; endosome membrane
Molecular Function: protein binding; beta-2-microglobulin binding; exogenous lipid antigen binding; endogenous lipid antigen binding
Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; immune response
Research Articles on CD1a
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Products associated with anti-CD1a antibody
Pathways associated with anti-CD1a antibody
Diseases associated with anti-CD1a antibody
Organs/Tissues associated with anti-CD1a antibody
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