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anti-CD2 antibody :: Mouse anti-Human. CD2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438458 anti-CD2 antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD2, Monoclonal Antibody

 Also Known As   

CD2

 Product Synonym Names    Erythrocyte receptor; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; Rosette receptor; SRBC; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11
 Product Gene Name   

anti-CD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186990
 3D Structure    ModBase 3D Structure for P06729
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 Clonality    Monoclonal
 Isotype    IgG2a, kappa
 Clone Number    1E7E8.G4
 Host    Mouse
 Species Reactivity    Human.
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 Specificity    CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.
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 Localization    Cell surface
 Positive Control    293T or Jurkat cells. Lymph node and tonsil
 Human Chromosomal Location    1p13.1
 Immunogen    Human Thymocytes/Sezary T cells
 Quantity and Buffer    0.5 ml at 200ug/ml with BSA and azide
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 Preparation and Storage    Store at 2 to 8 degree C. Antibody is stable for 24 months.
 Other Notes    Small volumes of anti-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD2 antibody   

ELISA (EIA), Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

 Application Notes for anti-CD2 antibody    ELISA (For coating, order Ab without BSA); Functional Studies (Order Ab without Azide); Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml); Western Blotting (0.5-1ug/ml); Immunoprecipitation (0.5-1ug/500ug protein lysate); Immunohistology (Frozen) (0.5-1ug/ml for 30 minutes at RT) Optimal dilution for a specific application should be determined.
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NCBI/Uniprot data below describe general gene information for CD2. It may not necessarily be applicable to this product.
 NCBI GI #    156071472
 NCBI GeneID    914
 NCBI Accession #    NP_001758.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001767.3 [Other Products]
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 UniProt Primary Accession #    P06729 [Other Products]
 UniProt Secondary Accession #    Q96TE5 [Other Products]
 UniProt Related Accession #    P06729 [Other Products]
 Molecular Weight    50kDa
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 NCBI Official Full Name    T-cell surface antigen CD2
 NCBI Official Synonym Full Names    CD2 molecule
 NCBI Official Symbol    CD2 [Similar Products]
 NCBI Official Synonym Symbols   
T11; SRBC; LFA-2
[Similar Products]
 NCBI Protein Information    T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor
 UniProt Protein Name    T-cell surface antigen CD2
 UniProt Synonym Protein Names   
Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
 Protein Family    CD2
 UniProt Gene Name    CD2 [Similar Products]
 UniProt Synonym Gene Names    SRBC [Similar Products]
 UniProt Entry Name    CD2_HUMAN
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 NCBI Summary for CD2    CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
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 UniProt Comments for CD2    CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Protein type: Membrane protein, integral; Cell surface; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: internal side of plasma membrane; anchored to plasma membrane; cell surface; integral to plasma membrane; plasma membrane; extracellular region; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; T cell activation; apoptosis; natural killer cell activation; regulation of T cell differentiation; positive regulation of tumor necrosis factor production; lipid raft polarization; blood coagulation; leukocyte migration; positive regulation of myeloid dendritic cell activation
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Product References and Citations for anti-CD2 antibody

   1. K.F.?Kozarsky, et al, (1993) Cell Immunol ?150: 235-246.
2. Leukocyte Typing?V (S.F. Schlossman, et al, eds.) Oxford?University Press, Oxford, (1995) p.?342-352.
3. G.M. Bell &?J.B. Imboden, (1995) J Immunol 155:?2805-2807.
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 Research Articles on CD2    1. ERGdel may be a pure surrogate of CD2-positivity--which has been suggested to be a good prognositc marker in childhood ALL
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD2 antibodyPathways associated with anti-CD2 antibody
 Reference Product  PubMed Publications
 CD58 antibody  >416 publications with CD2 and CD58
 PTPRC antibody  >343 publications with CD2 and PTPRC
 CD2AP antibody  >156 publications with CD2 and CD2AP
 CD48 antibody  >147 publications with CD2 and CD48
 LCK antibody  >79 publications with CD2 and LCK
 SH3KBP1 antibody  >19 publications with CD2 and SH3KBP1
 CD2BP2 antibody  >13 publications with CD2 and CD2BP2
 ITK antibody  >11 publications with CD2 and ITK
 CD8A antibody  >3 publications with CD2 and CD8A
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CD2 antibodyOrgans/Tissues associated with anti-CD2 antibody
 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >854 publications with CD2 and Lymphoma
 Skin Diseases Antibodies  >321 publications with CD2 and Skin Diseases
 Necrosis Antibodies  >313 publications with CD2 and Necrosis
 Inflammation Antibodies  >234 publications with CD2 and Inflammation
 Kidney Diseases Antibodies  >151 publications with CD2 and Kidney Diseases
 Liver Diseases Antibodies  >126 publications with CD2 and Liver Diseases
 Skin Neoplasms Antibodies  >123 publications with CD2 and Skin Neoplasms
 Lung Diseases Antibodies  >104 publications with CD2 and Lung Diseases
 Vascular Diseases Antibodies  >100 publications with CD2 and Vascular Diseases
 Anemia Antibodies  >100 publications with CD2 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4655 publications with CD2 and Blood
 Bone Antibodies  >765 publications with CD2 and Bone
 Muscle Antibodies  >544 publications with CD2 and Muscle
 Kidney Antibodies  >489 publications with CD2 and Kidney
 Thymus Antibodies  >437 publications with CD2 and Thymus
 Lymph Node Antibodies  >389 publications with CD2 and Lymph Node
 Heart Antibodies  >310 publications with CD2 and Heart
 Spleen Antibodies  >277 publications with CD2 and Spleen
 Intestine Antibodies  >253 publications with CD2 and Intestine
 Lung Antibodies  >185 publications with CD2 and Lung
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