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anti-MS4A1 antibody :: Mouse anti-Human CD20 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8203394
Flow Cytometry (FC/FACS)
Unit / Price
0.05 mL  /  $175 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD20 (MS4A1), Monoclonal Antibody

 Also Known As   

Anti-CD20 Antibody

 Product Synonym Names    CD20; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD antigen CD20
 Product Gene Name   

anti-MS4A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112210
 3D Structure    ModBase 3D Structure for P11836
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognises human CD20.
 Purity/Purification    The antibody was purified by affinity chromatography.
 Form/Format    Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.
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 Preparation and Storage    Shipped and store at 4 degree C for one year. Do not freeze.
 Other Notes    Small volumes of anti-MS4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MS4A1 antibody

   Mouse monoclonal antibody to CD20
 Applications Tested/Suitable for anti-MS4A1 antibody   

Immunofluoresence (IF), Flow Cytometry (FC/FACS)

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 Flow Cytometry (FC/FACS) of anti-MS4A1 antibody    Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD20 Antibody, followed by anti-mouse IgG PE.
anti-MS4A1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for MS4A1. It may not necessarily be applicable to this product.
 NCBI GI #    23110987
 NCBI GeneID    931
 NCBI Accession #    NP_068769.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021950.3 [Other Products]
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 UniProt Primary Accession #    P11836 [Other Products]
 UniProt Secondary Accession #    P08984; Q13963; A6NMS4; B4DT24 [Other Products]
 UniProt Related Accession #    P11836 [Other Products]
 Molecular Weight    14,581 Da
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 NCBI Official Full Name    B-lymphocyte antigen CD20
 NCBI Official Synonym Full Names    membrane-spanning 4-domains, subfamily A, member 1
 NCBI Official Symbol    MS4A1 [Similar Products]
 NCBI Official Synonym Symbols   
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD20
 UniProt Protein Name    B-lymphocyte antigen CD20
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
 Protein Family    CD209 antigen
 UniProt Gene Name    MS4A1 [Similar Products]
 UniProt Synonym Gene Names    CD20 [Similar Products]
 UniProt Entry Name    CD20_HUMAN
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 NCBI Summary for MS4A1    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MS4A1    MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.

Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5
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 Research Articles on MS4A1    1. This study identified a novel D393-CD20-derived MHC Class II restricted epitopes that bind various HLA-DR alleles. IFN-gamma-producing D393-CD20 specific CD4 T cell responses were detected in blood lymphocytes from lymphoma patients and D393-CD20 specific CD4 Th1 clones were able to recognize both lymphoma cell lines and autologous lymphoma cells and to induce their apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MS4A1 antibodyPathways associated with anti-MS4A1 antibody
 Reference Product  PubMed Publications
 CD40 antibody  >182 publications with MS4A1 and CD40
 PRDM1 antibody  >8 publications with MS4A1 and PRDM1
 MS4A3 antibody  >7 publications with MS4A1 and MS4A3
 LCK antibody  >4 publications with MS4A1 and LCK
 LYN antibody  >4 publications with MS4A1 and LYN
 HLA-DRA antibody  >4 publications with MS4A1 and HLA-DRA
 MS4A7 antibody  >3 publications with MS4A1 and MS4A7
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-MS4A1 antibodyOrgans/Tissues associated with anti-MS4A1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >371 publications with MS4A1 and Cardiovascular Diseases
 Inflammation Antibodies  >302 publications with MS4A1 and Inflammation
 Necrosis Antibodies  >251 publications with MS4A1 and Necrosis
 Chromosome Aberrations Antibodies  >182 publications with MS4A1 and Chromosome Aberrations
 Lung Diseases Antibodies  >172 publications with MS4A1 and Lung Diseases
 Hyperplasia Antibodies  >148 publications with MS4A1 and Hyperplasia
 Kidney Diseases Antibodies  >147 publications with MS4A1 and Kidney Diseases
 Liver Diseases Antibodies  >121 publications with MS4A1 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >88 publications with MS4A1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >81 publications with MS4A1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3256 publications with MS4A1 and Blood
 Lymph Node Antibodies  >531 publications with MS4A1 and Lymph Node
 Lymph Antibodies  >507 publications with MS4A1 and Lymph
 Skin Antibodies  >351 publications with MS4A1 and Skin
 Kidney Antibodies  >285 publications with MS4A1 and Kidney
 Spleen Antibodies  >220 publications with MS4A1 and Spleen
 Vascular Antibodies  >215 publications with MS4A1 and Vascular
 Lung Antibodies  >198 publications with MS4A1 and Lung
 Brain Antibodies  >111 publications with MS4A1 and Brain
 Stomach Antibodies  >90 publications with MS4A1 and Stomach
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