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anti-CD20 antibody :: Mouse CD20 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS212274
Unit / Price
0.2 mg  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD20, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD20

 Product Gene Name   

anti-CD20 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112210
 3D Structure    ModBase 3D Structure for P11836
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    2H7
 Host    Mouse
 Species Reactivity    Rhesus Monkey
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD20 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD20 antibody

   Mouse anti Human CD20 antibody, clone 2H7 recognizes the human CD20 cell surface antigen, a 33-37 kDa non-glycosylated phosphoprotein. The CD20 antigen is expressed during pre-B-cell development. It is present on both resting and activated B-cells but is lost prior to terminal B-cell differentiation into plasma cells. The epitope recognized by clone 2H7 has been mapped to the following sequence found in the large extracellular loop of human CD20: YNCEPANPSEKNSPST. Furthermore it appears that Mouse anti Human CD20 antibody, clone 2H7 only recognizes human CD20 in its native oligomeric form (Polyak et al. 2002).
 Applications Tested/Suitable for anti-CD20 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS)

 Application Notes for anti-CD20 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
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 Testing Data of anti-CD20 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD20:FITC (MBS210754)
anti-CD20 antibody Testing Data image
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 Testing Data of anti-CD20 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD20:Alexa Fluor 647 (MBS212274A647)
anti-CD20 antibody Testing Data image
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 Testing Data of anti-CD20 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD20
anti-CD20 antibody Testing Data image
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 Testing Data of anti-CD20 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD20:Biotin (MBS210355)
anti-CD20 antibody Testing Data image
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 Testing Data of anti-CD20 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD20:Alexa Fluor 488 (MBS212274A488)
anti-CD20 antibody Testing Data image
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 Testing Data of anti-CD20 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD20: Pacific Blue (MBS212274PB)
anti-CD20 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD20. It may not necessarily be applicable to this product.
 NCBI GI #    23110987
 NCBI GeneID    931
 NCBI Accession #    NP_068769.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021950.3 [Other Products]
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 UniProt Primary Accession #    P11836 [Other Products]
 UniProt Secondary Accession #    P08984; Q13963; A6NMS4; B4DT24 [Other Products]
 UniProt Related Accession #    P11836 [Other Products]
 Molecular Weight    14,581 Da
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 NCBI Official Full Name    B-lymphocyte antigen CD20
 NCBI Official Synonym Full Names    membrane-spanning 4-domains, subfamily A, member 1
 NCBI Official Symbol    MS4A1 [Similar Products]
 NCBI Official Synonym Symbols   
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16
 UniProt Protein Name    B-lymphocyte antigen CD20
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
 Protein Family    CD209 antigen
 UniProt Gene Name    MS4A1 [Similar Products]
 UniProt Synonym Gene Names    CD20 [Similar Products]
 UniProt Entry Name    CD20_HUMAN
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 NCBI Summary for CD20    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD20    MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.

Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5
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 Research Articles on CD20    1. CD20 in multiple myeloma without the t(11;14) may have a role in poor prognosis and aberrant expression of Wnt signaling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD20 antibodyPathways associated with anti-CD20 antibody
 Reference Product  PubMed Publications
 CD19 antibody  >918 publications with CD20 and CD19
 CD22 antibody  >352 publications with CD20 and CD22
 CD79A antibody  >302 publications with CD20 and CD79A
 CD40 antibody  >174 publications with CD20 and CD40
 CD79B antibody  >165 publications with CD20 and CD79B
 POU2AF1 antibody  >7 publications with CD20 and POU2AF1
 LYN antibody  >4 publications with CD20 and LYN
 LCK antibody  >4 publications with CD20 and LCK
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD20 antibodyOrgans/Tissues associated with anti-CD20 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >365 publications with CD20 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >303 publications with CD20 and Neoplasms, Experimental
 Respiratory Tract Diseases Antibodies  >298 publications with CD20 and Respiratory Tract Diseases
 Inflammation Antibodies  >287 publications with CD20 and Inflammation
 Necrosis Antibodies  >245 publications with CD20 and Necrosis
 Carcinoma Antibodies  >196 publications with CD20 and Carcinoma
 Skin Neoplasms Antibodies  >181 publications with CD20 and Skin Neoplasms
 Chromosome Aberrations Antibodies  >180 publications with CD20 and Chromosome Aberrations
 Lung Diseases Antibodies  >165 publications with CD20 and Lung Diseases
 Hyperplasia Antibodies  >146 publications with CD20 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3184 publications with CD20 and Blood
 Lymph Node Antibodies  >525 publications with CD20 and Lymph Node
 Lymph Antibodies  >501 publications with CD20 and Lymph
 Skin Antibodies  >341 publications with CD20 and Skin
 Kidney Antibodies  >277 publications with CD20 and Kidney
 Spleen Antibodies  >219 publications with CD20 and Spleen
 Vascular Antibodies  >212 publications with CD20 and Vascular
 Lung Antibodies  >187 publications with CD20 and Lung
 Brain Antibodies  >108 publications with CD20 and Brain
 Stomach Antibodies  >88 publications with CD20 and Stomach
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