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anti-CD204 antibody :: Rat CD204 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214931
Unit / Price
0.25 mg  /  $485 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD204, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD204

 Product Gene Name   

anti-CD204 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    2F8
 Host    Rat
 Species Reactivity    Channel catfish, Pig
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Raw 264 cell line
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD204 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD204 antibody   

Immunohistology Frozen*, ELISA (EIA), Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)*

 Application Notes for anti-CD204 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Immunohistology - Frozen: Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
Western Blotting: Application Note: This product recognises CD204 in J774 cells under non-reduced conditions only.
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 Testing Data of anti-CD204 antibody    Staining of mouse peritoneal macrophages with Rat anti Mouse CD204:FITC (MBS214937)
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Staining of mouse peritoneal macrophages with Rat anti Mouse CD204: Alexa Fluor 647 (MBS214931A647)
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD204 antibody, clone 2F8 followed by horseradish peroxidase Goat anti Rat IgG antibody (MBS235195). High power
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Staining of mouse peritoneal macrophages with Rat anti Mouse CD204: Biotin (MBS214934)
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Western Blot staining of J774 lysate (non reduced) probed with Rat anti Mouse CD204
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Staining of mouse peritoneal macrophages cells with Rat anti Mouse CD204:FITC (MBS210655)
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD204 antibody, clone 2F8 followed by horseradish peroxidase Goat anti Rat IgG antibody (MBS235195). Medium power
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD204 antibody, clone 2F8 followed by horseradish peroxidase Goat anti Rat IgG antibody (MBS235195). Low power
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Staining of mouse peritoneal macrophages with Rat anti Mouse CD204: Low Endotoxin (MBS214936)
anti-CD204 antibody Testing Data image
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 Testing Data of anti-CD204 antibody    Staining of mouse peritoneal macrophages with Rat anti Mouse CD204: Alexa Fluor 488 (MBS214931A488)
anti-CD204 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD204. It may not necessarily be applicable to this product.
 NCBI GI #    164664520
 NCBI GeneID    20288
 NCBI Accession #    NP_001106797.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001113326.1 [Other Products]
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 UniProt Secondary Accession #    Q923G0; Q9QZ56; E9QNQ5 [Other Products]
 UniProt Related Accession #    P30204 [Other Products]
 Molecular Weight    38,773 Da
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 NCBI Official Full Name    macrophage scavenger receptor types I and II isoform b
 NCBI Official Synonym Full Names    macrophage scavenger receptor 1
 NCBI Official Symbol    Msr1 [Similar Products]
 NCBI Official Synonym Symbols   
MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
[Similar Products]
 NCBI Protein Information    macrophage scavenger receptor types I and II; SR-A; macrophage acetylated LDL receptor I and II; scavenger receptor type A
 UniProt Protein Name    Macrophage scavenger receptor types I and II
 UniProt Synonym Protein Names   
Macrophage acetylated LDL receptor I and II; Scavenger receptor type A; SR-A; CD_antigen: CD204
 UniProt Gene Name    Msr1 [Similar Products]
 UniProt Synonym Gene Names    Scvr; SR-A [Similar Products]
 UniProt Entry Name    MSRE_MOUSE
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 UniProt Comments for CD204    MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: collagen; membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; cytosol

Molecular Function: low-density lipoprotein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol transport; lipoprotein transport; endocytosis
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 Research Articles on CD204    1. our data indicate that SR-A localizes in LRs and that LRs are required to couple SR-A to PLA2 activation during SRA-mediated macrophage attachment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD204 antibodyDiseases associated with anti-CD204 antibody
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >60 publications with CD204 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >48 publications with CD204 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >41 publications with CD204 and Prostatic Neoplasms
 Inflammation Antibodies  >35 publications with CD204 and Inflammation
 Lung Diseases Antibodies  >24 publications with CD204 and Lung Diseases
 Necrosis Antibodies  >24 publications with CD204 and Necrosis
 Disease Models, Animal Antibodies  >22 publications with CD204 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >10 publications with CD204 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >10 publications with CD204 and Lung Neoplasms
 Fibrosis Antibodies  >9 publications with CD204 and Fibrosis
Organs/Tissues associated with anti-CD204 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with CD204 and Blood
 Lung Antibodies  >29 publications with CD204 and Lung
 Bone Antibodies  >16 publications with CD204 and Bone
 Bone Marrow Antibodies  >14 publications with CD204 and Bone Marrow
 Brain Antibodies  >9 publications with CD204 and Brain
 Spleen Antibodies  >5 publications with CD204 and Spleen
 Skin Antibodies  >4 publications with CD204 and Skin
 Thymus Antibodies  >2 publications with CD204 and Thymus
 Pancreas Antibodies  >2 publications with CD204 and Pancreas
 Joint Antibodies  >2 publications with CD204 and Joint
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