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anti-CD209 antibody :: Mouse CD209 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213786
Unit / Price
100 Tests  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD209, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD209:RPE

 Product Gene Name   

anti-CD209 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604672
 3D Structure    ModBase 3D Structure for Q9NNX6
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MR-1
 Host    Mouse
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 Form/Format    Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
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 Reconstitution    Reconstitute with 1 ml distilled water
Perservative Stabilisers
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-CD209 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD209 antibody

   Mouse anti Human CD209 antibody, clone MR-1 recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a 45kD C-type lectin that binds ICAM-3 also known as CD209. CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro.CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's. Clone MR-1 is reported to partially block the functional activity of DC-SIGN (Melero et al.).
 Applications Tested/Suitable for anti-CD209 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD209 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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 Testing Data of anti-CD209 antibody    Staining of CD209 transfected K562 cells with Mouse anti Human CD209: Alexa Fluor 647 (MBS215905A647)
anti-CD209 antibody Testing Data image
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 Testing Data of anti-CD209 antibody    Staining of CD209 transfected K562 cells with Mouse anti Human CD209: Alexa Fluor 488 (MBS215905A488)
anti-CD209 antibody Testing Data image
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 Testing Data of anti-CD209 antibody    Staining of CD209 transfected K562 cells with Mouse anti Human CD209 (MBS211234)
anti-CD209 antibody Testing Data image
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 Testing Data of anti-CD209 antibody    Staining of CD209 transfected K562 cells with Mouse anti Human CD209 (MBS215905)
anti-CD209 antibody Testing Data image
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 Testing Data of anti-CD209 antibody    Staining of CD209 transfected K562 cells with Mouse anti Human CD209: FITC (MBS215910)
anti-CD209 antibody Testing Data image
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 Testing Data of anti-CD209 antibody    Staining of CD209 transfected K562 cells with Mouse anti Human CD209: Biotin (MBS215908)
anti-CD209 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD209. It may not necessarily be applicable to this product.
 NCBI GI #    223029380
 NCBI GeneID    30835
 NCBI Accession #    NP_001138365.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001144893.1 [Other Products]
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 UniProt Primary Accession #    Q9NNX6 [Other Products]
 UniProt Secondary Accession #    Q2TB19; Q96QP7; Q96QP8; Q96QP9; Q96QQ0; Q96QQ1; Q96QQ2; Q96QQ3; A8KAM4; A8MVQ9; G5E9C4 [Other Products]
 UniProt Related Accession #    Q9NNX6 [Other Products]
 Molecular Weight    33,874 Da
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 NCBI Official Full Name    CD209 antigen isoform 5
 NCBI Official Synonym Full Names    CD209 molecule
 NCBI Official Symbol    CD209 [Similar Products]
 NCBI Official Synonym Symbols   
CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
[Similar Products]
 NCBI Protein Information    CD209 antigen; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; HIV gpl20-binding protein; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
 UniProt Protein Name    CD209 antigen
 UniProt Synonym Protein Names   
C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD_antigen: CD209
 Protein Family    CD209 antigen
 UniProt Gene Name    CD209 [Similar Products]
 UniProt Synonym Gene Names    CLEC4L; DC-SIGN; DC-SIGN1 [Similar Products]
 UniProt Entry Name    CD209_HUMAN
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 NCBI Summary for CD209    This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
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 UniProt Comments for CD209    CD209: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cell surface; membrane; cytoplasm; integral to membrane; plasma membrane

Molecular Function: mannose binding; protein binding; peptide antigen binding; metal ion binding; virion binding; carbohydrate binding

Biological Process: heterophilic cell adhesion; cell-cell recognition; antigen processing and presentation; leukocyte adhesion; virus-host interaction; regulation of T cell proliferation; innate immune response; endocytosis; peptide antigen transport; viral genome replication; virion attachment to host cell surface receptor

Disease: Mycobacterium Tuberculosis, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on CD209    1. Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD209 antibodyDiseases associated with anti-CD209 antibody
 Products by Pathway  Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >33 publications with CD209 and Inflammation
 HIV Infections Antibodies  >21 publications with CD209 and HIV Infections
 Respiratory Tract Diseases Antibodies  >20 publications with CD209 and Respiratory Tract Diseases
 Dengue Antibodies  >20 publications with CD209 and Dengue
 Tuberculosis, Pulmonary Antibodies  >13 publications with CD209 and Tuberculosis, Pulmonary
 Lung Diseases Antibodies  >12 publications with CD209 and Lung Diseases
 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies  >10 publications with CD209 and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
 Cardiovascular Diseases Antibodies  >8 publications with CD209 and Cardiovascular Diseases
 Death Antibodies  >8 publications with CD209 and Death
 Atherosclerosis Antibodies  >5 publications with CD209 and Atherosclerosis
Organs/Tissues associated with anti-CD209 antibody
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >11 publications with CD209 and Placenta
 Intestine Antibodies  >10 publications with CD209 and Intestine
 Brain Antibodies  >8 publications with CD209 and Brain
 Uterus Antibodies  >6 publications with CD209 and Uterus
 Eye Antibodies  >3 publications with CD209 and Eye
 Pharynx Antibodies  >3 publications with CD209 and Pharynx
 Muscle Antibodies  >3 publications with CD209 and Muscle
 Thymus Antibodies  >2 publications with CD209 and Thymus
 Pancreas Antibodies  >2 publications with CD209 and Pancreas
 Adipose Tissue Antibodies  >1 publications with CD209 and Adipose Tissue
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