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anti-CD22 antibody :: Mouse anti-Human CD22 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS249124
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD22, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone 1B1] (IgG1) to Human CD22

 Product Synonym Names    Anti-CD22 Antibody (clone 1B1) IHC-plus; CD22; CD22 molecule; CD22 antigen; SIGLEC2; SIGLEC-2; T-cell surface antigen Leu-14; B-cell receptor CD22; BL-CAM; Human CD22
 Product Gene Name   

anti-CD22 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107266
 3D Structure    ModBase 3D Structure for P20273
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1B1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human CD22
 Purity/Purification    Protein A/G Purified
 Form/Format    PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Full length human recombinant protein of human CD22(NP_001762) produced in HEK293T cell.
 Antigen type    Recombinant Protein
 Immunogen Type    Recombinant protein
 Immunogen    CD22 antibody was raised against full length human recombinant protein of human CD22(NP_001762) produced in HEK293T cell.
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-CD22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD22 antibody

   Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules .
 Product Categories/Family for anti-CD22 antibody    Family: Immunoglobulin
 Applications Tested/Suitable for anti-CD22 antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-CD22 antibody    IF (1:100), IHC-P (5 ug/ml), WB (1:4000)
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 Immunohistochemistry (IHC) of anti-CD22 antibody    Anti-CD22 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD22 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CD22 antibody    Anti-CD22 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CD22.
anti-CD22 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-CD22 antibody    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD22 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD22.
anti-CD22 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD22. It may not necessarily be applicable to this product.
 NCBI GI #    157168355
 NCBI GeneID    933
 NCBI Accession #    NP_001762.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001771.3 [Other Products]
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 UniProt Primary Accession #    P20273 [Other Products]
 UniProt Secondary Accession #    O95699; O95701; O95702; O95703; Q01665; Q32M46; Q92872; Q92873; Q9UQA6; F5GYU4; F5H7U3 [Other Products]
 UniProt Related Accession #    P20273 [Other Products]
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 NCBI Official Full Name    B-cell receptor CD22 isoform 1
 NCBI Official Synonym Full Names    CD22 molecule
 NCBI Official Symbol    CD22 [Similar Products]
 NCBI Official Synonym Symbols   
SIGLEC2; SIGLEC-2
[Similar Products]
 NCBI Protein Information    B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
 UniProt Protein Name    B-cell receptor CD22
 UniProt Synonym Protein Names   
B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22
 Protein Family    CD226 antigen
 UniProt Gene Name    CD22 [Similar Products]
 UniProt Synonym Gene Names    SIGLEC2; BL-CAM; Siglec-2 [Similar Products]
 UniProt Entry Name    CD22_HUMAN
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 UniProt Comments for CD22    CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; external side of plasma membrane

Molecular Function: protein binding; carbohydrate binding

Biological Process: cell adhesion
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 Research Articles on CD22    1. study detected the expression of CD22 and CD72 on B cells of myasthenia gravis, compared to multiple sclerosis patient controls and healthy controls y
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD22 antibodyDiseases associated with anti-CD22 antibody
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >958 publications with CD22 and Immune System Diseases
 Neoplasms, Experimental Antibodies  >105 publications with CD22 and Neoplasms, Experimental
 Death Antibodies  >63 publications with CD22 and Death
 Inflammation Antibodies  >56 publications with CD22 and Inflammation
 Necrosis Antibodies  >51 publications with CD22 and Necrosis
 Respiratory Tract Diseases Antibodies  >46 publications with CD22 and Respiratory Tract Diseases
 Cell Transformation, Neoplastic Antibodies  >23 publications with CD22 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >22 publications with CD22 and Kidney Diseases
 Liver Diseases Antibodies  >19 publications with CD22 and Liver Diseases
 Lung Diseases Antibodies  >18 publications with CD22 and Lung Diseases
Organs/Tissues associated with anti-CD22 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1051 publications with CD22 and Blood
 Bone Marrow Antibodies  >289 publications with CD22 and Bone Marrow
 Spleen Antibodies  >122 publications with CD22 and Spleen
 Lymph Node Antibodies  >111 publications with CD22 and Lymph Node
 Lymph Antibodies  >101 publications with CD22 and Lymph
 Skin Antibodies  >47 publications with CD22 and Skin
 Lung Antibodies  >32 publications with CD22 and Lung
 Thymus Antibodies  >31 publications with CD22 and Thymus
 Tonsil Antibodies  >31 publications with CD22 and Tonsil
 Kidney Antibodies  >31 publications with CD22 and Kidney
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