NP_006557.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,614 Da
NCBI Official Full Name
CD226 antigen isoform a
NCBI Official Synonym Full Names
CD226 molecule
NCBI Protein Information
CD226 antigen; DNAX accessory molecule 1; DNAX accessory molecule-1; T lineage-specific activation antigen 1 antigen; adhesion glycoprotein; platelet and T cell activation antigen 1
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1; DNAM-1; CD_antigen: CD226
UniProt Synonym Gene Names
UniProt Entry Name
CD226_HUMAN
NCBI Summary for CD226
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Comments for CD226
DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q22.3
Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft
Molecular Function: integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding
Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; cell adhesion; signal transduction; positive regulation of mast cell activation
Research Articles on CD226
Precautions
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Products associated with anti-CD226 antibody
Pathways associated with anti-CD226 antibody
Diseases associated with anti-CD226 antibody
Organs/Tissues associated with anti-CD226 antibody
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