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anti-CD24 antibody :: Rat CD24 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215809 anti-CD24 antibody
Unit / Price
0.025 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD24, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD24

 Product Gene Name   

anti-CD24 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P24807
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    M1/69
 Host    Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    T-cell enriched spleen cells from B10 mice
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD24 antibody

   Rat anti Mouse CD24 antibody, clone M1/69 recognizes murine CD24 (also known as heat stable antigen), a 35-45kDa cell surface glycoprotein that is variably glycosylated.The M1/69 antigen is differentially expressed by developing haematopoietic cells including B-cells, myeloid precursors, thymocytes and erythroid cells. CD24 is not expressed by mouse peripheral T-cells and is a marker of haematopoietic differentiation in both B- and T-cell lineages. Rat anti Mouse CD24 antibody, clone M1/69 has been reported to agglutinate mouse red blood cells (RBCs) and to lyse mouse RBCs and thymocytes in the presence of complement (Springer. et al. 1978).
 Applications Tested/Suitable for anti-CD24 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD24 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Maximum Dilution: 1/10
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NCBI/Uniprot data below describe general gene information for CD24. It may not necessarily be applicable to this product.
 NCBI GI #    6753342
 NCBI GeneID    12484
 NCBI Accession #    NP_033976.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009846.2 [Other Products]
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 UniProt Primary Accession #    P24807 [Other Products]
 UniProt Secondary Accession #    P26691 [Other Products]
 UniProt Related Accession #    P24807 [Other Products]
 Molecular Weight    7,797 Da
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 NCBI Official Full Name    signal transducer CD24
 NCBI Official Synonym Full Names    CD24a antigen
 NCBI Official Symbol    Cd24a [Similar Products]
 NCBI Official Synonym Symbols   
HSA; Cd24; Ly-52; nectadrin
[Similar Products]
 NCBI Protein Information    signal transducer CD24; M1/69-J11D heat stable antigen; R13-Ag; X62 heat stable antigen; cluster of differentiation 24; lymphocyte antigen 52
 UniProt Protein Name    Signal transducer CD24
 UniProt Synonym Protein Names   
Lymphocyte antigen 52; Ly-52; M1/69-J11D heat stable antigen; HSA; Nectadrin; R13-Ag; X62 heat stable antigen; CD_antigen: CD24
 Protein Family    Signal transducer
 UniProt Gene Name    Cd24 [Similar Products]
 UniProt Synonym Gene Names    Cd24a; Ly-52; Ly-52; HSA [Similar Products]
 UniProt Entry Name    CD24_MOUSE
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 UniProt Comments for CD24    CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Cell surface; Membrane protein, GPI anchor

Cellular Component: anchored to external side of plasma membrane; cell surface; membrane; cell; microvillus membrane; plasma membrane; intracellular; cytosol; external side of plasma membrane; lipid raft

Molecular Function: protein binding; protein tyrosine kinase activator activity; carbohydrate binding; protein kinase binding

Biological Process: positive regulation of MAP kinase activity; positive regulation of inflammatory response to antigenic stimulus; elevation of cytosolic calcium ion concentration; regulation of cell-cell adhesion mediated by integrin; leukocyte adhesion; cell surface receptor linked signal transduction; negative regulation of neuroblast proliferation; response to molecule of bacterial origin; negative regulation of transforming growth factor-beta3 production; cell adhesion; neurite development; positive regulation of B cell apoptosis; regulation of phosphorylation; positive regulation of integrin activation; cell activation; negative regulation of neuron differentiation; positive regulation of peptidyl-tyrosine phosphorylation; cholesterol homeostasis; negative regulation of erythrocyte aggregation; response to estrogen stimulus; regulation of MAPKKK cascade; synaptic vesicle endocytosis; T cell costimulation; regulation of cytokine and chemokine mediated signaling pathway; positive regulation of alpha-beta T cell proliferation; respiratory burst; positive regulation of calcium-mediated signaling; negative regulation of B cell proliferation; positive regulation of activated T cell proliferation; positive regulation of cell-cell adhesion mediated by integrin; negative regulation of neurogenesis; apoptotic mitochondrial changes; regulation of cell-cell adhesion; homotypic cell-cell adhesion; positive regulation of cell-cell adhesion; positive regulation of T cell mediated immune response to tumor cell; cell migration; positive regulation of cell adhesion mediated by integrin; positive regulation of T cell homeostatic proliferation; chemokine receptor transport out of lipid raft; leukocyte migration during inflammatory response; heterophilic cell adhesion; negative regulation of erythrocyte clearance; pre-B cell differentiation; apoptotic nuclear changes; negative regulation of T cell homeostatic proliferation; regulation of B cell differentiation; response to hypoxia; neuromuscular synaptic transmission
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 Research Articles on CD24    1. CD24 expression negatively regulates the NF-kappaB pathway following experimental traumatic brain injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD24 antibodyDiseases associated with anti-CD24 antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >16 publications with CD24 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >11 publications with CD24 and Neoplasms, Experimental
 Inflammation Antibodies  >6 publications with CD24 and Inflammation
 Mammary Neoplasms, Experimental Antibodies  >5 publications with CD24 and Mammary Neoplasms, Experimental
 Breast Neoplasms Antibodies  >5 publications with CD24 and Breast Neoplasms
 Adenocarcinoma Antibodies  >4 publications with CD24 and Adenocarcinoma
 Mammary Neoplasms, Animal Antibodies  >4 publications with CD24 and Mammary Neoplasms, Animal
 Neoplasm Metastasis Antibodies  >3 publications with CD24 and Neoplasm Metastasis
 Necrosis Antibodies  >3 publications with CD24 and Necrosis
 Liver Neoplasms, Experimental Antibodies  >2 publications with CD24 and Liver Neoplasms, Experimental
Organs/Tissues associated with anti-CD24 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >98 publications with CD24 and Blood
 Bone Antibodies  >38 publications with CD24 and Bone
 Bone Marrow Antibodies  >37 publications with CD24 and Bone Marrow
 Thymus Antibodies  >29 publications with CD24 and Thymus
 Other Antibodies  >26 publications with CD24 and Other
 Spleen Antibodies  >24 publications with CD24 and Spleen
 Brain Antibodies  >17 publications with CD24 and Brain
 Embryonic Tissue Antibodies  >11 publications with CD24 and Embryonic Tissue
 Liver Antibodies  >10 publications with CD24 and Liver
 Skin Antibodies  >9 publications with CD24 and Skin
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