NP_033976.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
7,797 Da
NCBI Official Full Name
signal transducer CD24
NCBI Official Synonym Full Names
CD24a antigen
NCBI Protein Information
signal transducer CD24; M1/69-J11D heat stable antigen; R13-Ag; X62 heat stable antigen; cluster of differentiation 24; lymphocyte antigen 52
UniProt Protein Name
Signal transducer CD24
UniProt Synonym Protein Names
Lymphocyte antigen 52; Ly-52; M1/69-J11D heat stable antigen; HSA; Nectadrin; R13-Ag; X62 heat stable antigen; CD_antigen: CD24
UniProt Synonym Gene Names
UniProt Entry Name
CD24_MOUSE
UniProt Comments for CD24
CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Cell surface; Membrane protein, GPI anchor
Cellular Component: anchored to external side of plasma membrane; cell surface; membrane; cell; microvillus membrane; plasma membrane; intracellular; cytosol; external side of plasma membrane; lipid raft
Molecular Function: protein binding; protein tyrosine kinase activator activity; carbohydrate binding; protein kinase binding
Biological Process: positive regulation of MAP kinase activity; positive regulation of inflammatory response to antigenic stimulus; elevation of cytosolic calcium ion concentration; regulation of cell-cell adhesion mediated by integrin; leukocyte adhesion; cell surface receptor linked signal transduction; negative regulation of neuroblast proliferation; response to molecule of bacterial origin; negative regulation of transforming growth factor-beta3 production; cell adhesion; neurite development; positive regulation of B cell apoptosis; regulation of phosphorylation; positive regulation of integrin activation; cell activation; negative regulation of neuron differentiation; positive regulation of peptidyl-tyrosine phosphorylation; cholesterol homeostasis; negative regulation of erythrocyte aggregation; response to estrogen stimulus; regulation of MAPKKK cascade; synaptic vesicle endocytosis; T cell costimulation; regulation of cytokine and chemokine mediated signaling pathway; positive regulation of alpha-beta T cell proliferation; respiratory burst; positive regulation of calcium-mediated signaling; negative regulation of B cell proliferation; positive regulation of activated T cell proliferation; positive regulation of cell-cell adhesion mediated by integrin; negative regulation of neurogenesis; apoptotic mitochondrial changes; regulation of cell-cell adhesion; homotypic cell-cell adhesion; positive regulation of cell-cell adhesion; positive regulation of T cell mediated immune response to tumor cell; cell migration; positive regulation of cell adhesion mediated by integrin; positive regulation of T cell homeostatic proliferation; chemokine receptor transport out of lipid raft; leukocyte migration during inflammatory response; heterophilic cell adhesion; negative regulation of erythrocyte clearance; pre-B cell differentiation; apoptotic nuclear changes; negative regulation of T cell homeostatic proliferation; regulation of B cell differentiation; response to hypoxia; neuromuscular synaptic transmission
Research Articles on CD24
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Pathways associated with anti-CD24 antibody
Diseases associated with anti-CD24 antibody
Disease Name |
Pubmed Publications |
Disease Models, Animal Antibodies |
>16 publications with CD24 and Disease Models, Animal |
Neoplasms, Experimental Antibodies |
>11 publications with CD24 and Neoplasms, Experimental |
Inflammation Antibodies |
>6 publications with CD24 and Inflammation |
Mammary Neoplasms, Experimental Antibodies |
>5 publications with CD24 and Mammary Neoplasms, Experimental |
Breast Neoplasms Antibodies |
>5 publications with CD24 and Breast Neoplasms |
Adenocarcinoma Antibodies |
>4 publications with CD24 and Adenocarcinoma |
Mammary Neoplasms, Animal Antibodies |
>4 publications with CD24 and Mammary Neoplasms, Animal |
Neoplasm Metastasis Antibodies |
>3 publications with CD24 and Neoplasm Metastasis |
Necrosis Antibodies |
>3 publications with CD24 and Necrosis |
Liver Neoplasms, Experimental Antibodies |
>2 publications with CD24 and Liver Neoplasms, Experimental |
Organs/Tissues associated with anti-CD24 antibody
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