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anti-CD25 antibody :: Rat CD25 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219338 anti-CD25 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD25, Monoclonal Antibody

★Popular Item★
 Also Known As   

RAT ANTI MOUSE CD25

 Product Gene Name   

anti-CD25 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01590
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    PC61.5.3
 Host    Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    B6.1 CTL cell line
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD25 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD25 antibody

   Rat anti Mouse CD25 antibody, clone PC61.5.3 reacts with the low affinity alpha chain of the interleukin-2 receptor present on activated T and B cells in mice. Rat anti Mouse CD25 antibody, clone PC61.5.3 is reported to inhibit IL-2 binding and IL-2 dependent proliferation.
 Applications Tested/Suitable for anti-CD25 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD25 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1 x 106 cells in 100ul.
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NCBI/Uniprot data below describe general gene information for CD25. It may not necessarily be applicable to this product.
 NCBI GI #    254540187
 NCBI GeneID    16184
 NCBI Accession #    NP_032393.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_008367.3 [Other Products]
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 UniProt Primary Accession #    P01590 [Other Products]
 UniProt Secondary Accession #    Q61731 [Other Products]
 UniProt Related Accession #    P01590 [Other Products]
 Molecular Weight    30,723 Da
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 NCBI Official Full Name    interleukin-2 receptor subunit alpha
 NCBI Official Synonym Full Names    interleukin 2 receptor, alpha chain
 NCBI Official Symbol    Il2ra [Similar Products]
 NCBI Official Synonym Symbols   
CD25; Il2r; Ly-43
[Similar Products]
 NCBI Protein Information    interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; p55 chain
 UniProt Protein Name    Interleukin-2 receptor subunit alpha
 UniProt Synonym Protein Names   
p55; CD_antigen: CD25
 UniProt Gene Name    Il2ra [Similar Products]
 UniProt Synonym Gene Names    Il2r; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA [Similar Products]
 UniProt Entry Name    IL2RA_MOUSE
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 UniProt Comments for CD25    IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; interleukin-2 receptor activity; drug binding; interleukin-2 binding

Biological Process: regulation of T cell homeostatic proliferation; Notch signaling pathway; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; positive regulation of T cell proliferation; T cell homeostasis; activated T cell apoptosis
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 Research Articles on CD25    1. our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD25 antibodyDiseases associated with anti-CD25 antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G Beta:gamma Signalling Through PI3Kgamma Pathway antibodies  G Beta:gamma Signalling Through PI3Kgamma Pathway Diagram
 G-protein Beta:gamma Signalling Pathway antibodies  G-protein Beta:gamma Signalling Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1295 publications with CD25 and Immune System Diseases
 Inflammation Antibodies  >541 publications with CD25 and Inflammation
 Necrosis Antibodies  >343 publications with CD25 and Necrosis
 Lung Diseases Antibodies  >198 publications with CD25 and Lung Diseases
 Liver Diseases Antibodies  >159 publications with CD25 and Liver Diseases
 Diabetes Mellitus, Type 1 Antibodies  >149 publications with CD25 and Diabetes Mellitus, Type 1
 Multiple Sclerosis Antibodies  >139 publications with CD25 and Multiple Sclerosis
 Cardiovascular Diseases Antibodies  >128 publications with CD25 and Cardiovascular Diseases
 Arthritis, Rheumatoid Antibodies  >117 publications with CD25 and Arthritis, Rheumatoid
 Kidney Diseases Antibodies  >95 publications with CD25 and Kidney Diseases
Organs/Tissues associated with anti-CD25 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >396 publications with CD25 and Spleen
 Lymph Node Antibodies  >312 publications with CD25 and Lymph Node
 Skin Antibodies  >223 publications with CD25 and Skin
 Thymus Antibodies  >209 publications with CD25 and Thymus
 Ovary Antibodies  >13 publications with CD25 and Ovary
 Mammary Gland Antibodies  >2 publications with CD25 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with CD25 and Uncharacterized Tissue
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