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anti-CD27  antibody :: Rabbit anti-Mouse CD27  Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2544480 anti-CD27  antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD27 , Monoclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti Mouse CD27  Monoclonal Antibody

 Product Gene Name   

anti-CD27  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M63928 mRNA
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Immunogen    Recombinant Mouse CD27 protein
 Buffer    0.2 mum filtered solution in PBS with 5% trehalose
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 Preparation and Storage    This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD27  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD27  antibody

   CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
 Applications Tested/Suitable for anti-CD27  antibody   

Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS)

 Application Notes for anti-CD27  antibody    Flow Cytometry: 0.5-2 mug/Test
ICC/IF: 10-25 mug/mL
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NCBI/Uniprot data below describe general gene information for CD27 . It may not necessarily be applicable to this product.
 NCBI GI #    4507587
 NCBI GeneID    939
 NCBI GenBank Nucleotide #    NM_001242.4 [Other Products]
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 UniProt Secondary Accession #    B2RDZ0 [Other Products]
 UniProt Related Accession #    P26842 [Other Products]
 Molecular Weight    29,137 Da
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 NCBI Official Full Name    CD27 antigen
 NCBI Official Synonym Full Names    CD27 molecule
 NCBI Official Symbol    CD27 [Similar Products]
 NCBI Official Synonym Symbols   
T14; S152; Tp55; TNFRSF7; S152. LPFS2
[Similar Products]
 NCBI Protein Information    CD27 antigen
 UniProt Protein Name    CD27 antigen
 UniProt Synonym Protein Names   
CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27
 UniProt Gene Name    CD27 [Similar Products]
 UniProt Synonym Gene Names    TNFRSF7 [Similar Products]
 UniProt Entry Name    CD27_HUMAN
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 NCBI Summary for CD27     The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD27     CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Protein type: Apoptosis; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane

Molecular Function: caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity

Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway

Disease: Lymphoproliferative Syndrome 2
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 Research Articles on CD27     1. HCV infection increased the frequency of CD4+CXCR5+ T cells and decreased the frequency of CD27+IgG+ B cells. CD4+CXCR5+ T cells activated CD27+IgG+ B cells via the secretion of IL-21.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD27  antibodyPathways associated with anti-CD27  antibody
 Reference Product  PubMed Publications
 CD70 antibody  >286 publications with CD27  and CD70
 CD5 antibody  >131 publications with CD27  and CD5
 IL10 antibody  >98 publications with CD27  and IL10
 CXCR3 antibody  >55 publications with CD27  and CXCR3
 TRAF2 antibody  >13 publications with CD27  and TRAF2
 SIVA1 antibody  >12 publications with CD27  and SIVA1
 TRAF3 antibody  >8 publications with CD27  and TRAF3
 CCR3 antibody  >4 publications with CD27  and CCR3
 CD40LG antibody  >1 publications with CD27  and CD40LG
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 TNFR2 Non-canonical NF-kB Pathway antibodies  TNFR2 Non-canonical NF-kB Pathway Diagram
 TNFs Bind Their Physiological Receptors Pathway antibodies  TNFs Bind Their Physiological Receptors Pathway Diagram
Diseases associated with anti-CD27  antibodyOrgans/Tissues associated with anti-CD27  antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1015 publications with CD27  and Immune System Diseases
 Necrosis Antibodies  >460 publications with CD27  and Necrosis
 Inflammation Antibodies  >218 publications with CD27  and Inflammation
 Nervous System Diseases Antibodies  >119 publications with CD27  and Nervous System Diseases
 Vascular Diseases Antibodies  >100 publications with CD27  and Vascular Diseases
 Carcinoma Antibodies  >73 publications with CD27  and Carcinoma
 Memory Disorders Antibodies  >49 publications with CD27  and Memory Disorders
 Kidney Diseases Antibodies  >46 publications with CD27  and Kidney Diseases
 Neoplasms, Experimental Antibodies  >45 publications with CD27  and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >23 publications with CD27  and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2630 publications with CD27  and Blood
 Lymph Node Antibodies  >193 publications with CD27  and Lymph Node
 Spleen Antibodies  >174 publications with CD27  and Spleen
 Lymph Antibodies  >156 publications with CD27  and Lymph
 Lung Antibodies  >102 publications with CD27  and Lung
 Kidney Antibodies  >97 publications with CD27  and Kidney
 Thymus Antibodies  >91 publications with CD27  and Thymus
 Tonsil Antibodies  >71 publications with CD27  and Tonsil
 Heart Antibodies  >47 publications with CD27  and Heart
 Intestine Antibodies  >44 publications with CD27  and Intestine
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