NM_001242.4
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,137 Da
NCBI Official Full Name
CD27 antigen
NCBI Official Synonym Full Names
CD27 molecule
NCBI Official Synonym Symbols
T14; S152; Tp55; TNFRSF7; S152. LPFS2 [Similar Products]
NCBI Protein Information
CD27 antigen
UniProt Protein Name
CD27 antigen
UniProt Synonym Protein Names
CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27
UniProt Synonym Gene Names
UniProt Entry Name
CD27_HUMAN
NCBI Summary for CD27
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for CD27
CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Protein type: Apoptosis; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane
Molecular Function: caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity
Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway
Disease: Lymphoproliferative Syndrome 2
Research Articles on CD27
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Products associated with anti-CD27 antibody
Pathways associated with anti-CD27 antibody
Diseases associated with anti-CD27 antibody
Organs/Tissues associated with anti-CD27 antibody
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