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anti-CD27 antibody :: anti-Mouse CD27 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS520087
Testing Data
Unit / Price
0.1 mg  /  $230 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD27, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Mouse CD27 FITC (Clone LG.3A10) (Armenian Hamster IgG1)

 Product Synonym Names    CD27 FITC (Clone LG.3A10) (Armenian Hamster IgG1); Anti-Mouse CD27 Monoclonal Antibody
 Product Gene Name   

anti-CD27 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (6554051..6560884). Location: 12p13
 OMIM    186711
 3D Structure    ModBase 3D Structure for P26842
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 Clonality    Monoclonal
 Isotype    Armenian hamster IgG1
 Clone Number    LG.3810
 Host    Armenian Hamster
 Species Reactivity    Mouse
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 Specificity    CD27 (Mouse CD27 Receptor)
 Form/Format    FITC
 Concentration    0.1 mg/ml (lot specific)
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 Immunogen    MCD27 tag expressing clones AR0524 and AR0530
 Donor    Armenian hamster spleen
 Fusion Partner    SP2/0 Murine Myeloma Partner
 Presentation    Biotin/FITC/PE conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
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 Preparation and Storage    For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin, FITC, No Azide), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CD27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD27 antibody

   anti-mouse CD27 Monoclonal Antibody is specific for the mouse CD27 receptor. CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both alphabeta and gammadelta T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8- precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events. This clone (LG.3A10) has been reported to work in Immunohistochemistry on frozen tissue sections, Flow Cytometry and in functional studies (stimulating).
 Applications Tested/Suitable for anti-CD27 antibody   

Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) (stimulating)

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 Testing Data of anti-CD27 antibody    anti-CD27 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD27. It may not necessarily be applicable to this product.
 NCBI GI #    4507587
 NCBI GeneID    939
 NCBI Accession #    NP_001233.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242.4 [Other Products]
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 UniProt Primary Accession #    P26842 [Other Products]
 UniProt Secondary Accession #    B2RDZ0 [Other Products]
 UniProt Related Accession #    P26842 [Other Products]
 Molecular Weight    29,137 Da
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 NCBI Official Full Name    CD27 antigen
 NCBI Official Synonym Full Names    CD27 molecule
 NCBI Official Symbol    CD27 [Similar Products]
 NCBI Official Synonym Symbols   
T14; S152; Tp55; TNFRSF7; S152. LPFS2
[Similar Products]
 NCBI Protein Information    CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7
 UniProt Protein Name    CD27 antigen
 UniProt Synonym Protein Names   
CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7
 Protein Family    CD27 antigen
 UniProt Gene Name    CD27 [Similar Products]
 UniProt Synonym Gene Names    TNFRSF7 [Similar Products]
 UniProt Entry Name    CD27_HUMAN
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 NCBI Summary for CD27    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD27    Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subunit structure: Homodimer. Interacts with SIVA1 and TRAF2. Ref.8 Ref.9

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Found in most T-lymphocytes.

Post-translational modification: Phosphorylated.O-glycosylated with core 1 or possibly core 8 glycans. Ref.10

Involvement in disease: Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.12

Sequence similarities: Contains 3 TNFR-Cys repeats.
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 Research Articles on CD27    1. We identified soluble CD27 as an immune modulator associated with enhanced human T cell activation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD27 antibodyDiseases associated with anti-CD27 antibody
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >821 publications with CD27 and Immune System Diseases
 Neoplasms Antibodies  >466 publications with CD27 and Neoplasms
 Necrosis Antibodies  >407 publications with CD27 and Necrosis
 Lymphoma Antibodies  >216 publications with CD27 and Lymphoma
 Inflammation Antibodies  >137 publications with CD27 and Inflammation
 Nervous System Diseases Antibodies  >92 publications with CD27 and Nervous System Diseases
 Skin Diseases Antibodies  >87 publications with CD27 and Skin Diseases
 Neoplasms, Experimental Antibodies  >74 publications with CD27 and Neoplasms, Experimental
 Liver Diseases Antibodies  >56 publications with CD27 and Liver Diseases
 Carcinoma Antibodies  >54 publications with CD27 and Carcinoma
Organs/Tissues associated with anti-CD27 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2115 publications with CD27 and Blood
 Lymph Node Antibodies  >164 publications with CD27 and Lymph Node
 Spleen Antibodies  >137 publications with CD27 and Spleen
 Lymph Antibodies  >134 publications with CD27 and Lymph
 Lung Antibodies  >78 publications with CD27 and Lung
 Thymus Antibodies  >76 publications with CD27 and Thymus
 Kidney Antibodies  >67 publications with CD27 and Kidney
 Tonsil Antibodies  >56 publications with CD27 and Tonsil
 Intestine Antibodies  >33 publications with CD27 and Intestine
 Heart Antibodies  >33 publications with CD27 and Heart
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