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anti-CD273 antibody :: Mouse CD273 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS217331
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD273, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD273:FITC

 Product Gene Name   

anti-CD273 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605723
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MIH14
 Host    Mouse
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Preparation
 Immunogen    Human B7-DC transfected L cells.
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD273 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD273 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD273 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: neat; Maximum Dilution: 1/5
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 Testing Data of anti-CD273 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD273:Alexa Fluor 488 (MBS214413A488)
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD273 antibody, clone MIH14 (MBS214413) followed by Histar detection system . High power
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD273 antibody, clone MIH14 (MBS214413) followed by Histar detection system . High power
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD273 antibody, clone MIH14 (MBS214413) followed by Histar detection system . Medium power
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD273:RPE (MBS217332)
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Immunofluorescence staining of human tonsil cryosection with Mouse nti Human CD273 antibody, clone MIH14 (MBS214413), red in A anti Mouse anti Human CD21antibo0dy, clone LB21 (MBS212051), green in B. C is the merged image with nuclei counterstained blue using DAPI. Medium power
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD273:FITC
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD273 antibody, clone MIH14 (MBS214413) followed by Histar detection system . Low power
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD273 Alexa Fluor 647 (MBS214413A647)
anti-CD273 antibody Testing Data image
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 Testing Data of anti-CD273 antibody    Immunofluorescence staining of human tonsil cryosection with Mouse nti Human CD273 antibody, clone MIH14 (MBS214413), red in A anti Mouse anti Human CD21antibo0dy, clone LB21 (MBS212051), green in B. C is the merged image with nuclei counterstained blue using DAPI. Low power
anti-CD273 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD273. It may not necessarily be applicable to this product.
 NCBI GI #    190014605
 NCBI GeneID    80380
 NCBI Accession #    NP_079515.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_025239.3 [Other Products]
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 UniProt Secondary Accession #    Q14CN8; Q5T7Z6; Q6JXL8; Q6JXL9 [Other Products]
 UniProt Related Accession #    Q9BQ51 [Other Products]
 Molecular Weight    20,745 Da
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 NCBI Official Full Name    programmed cell death 1 ligand 2
 NCBI Official Synonym Full Names    programmed cell death 1 ligand 2
 NCBI Official Symbol    PDCD1LG2 [Similar Products]
 NCBI Official Synonym Symbols   
B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
[Similar Products]
 NCBI Protein Information    programmed cell death 1 ligand 2; B7 dendritic cell molecule; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2
 UniProt Protein Name    Programmed cell death 1 ligand 2
 UniProt Synonym Protein Names   
Butyrophilin B7-DC; B7-DC; CD_antigen: CD273
 UniProt Gene Name    PDCD1LG2 [Similar Products]
 UniProt Synonym Gene Names    B7DC; CD273; PDCD1L2; PDL2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC [Similar Products]
 UniProt Entry Name    PD1L2_HUMAN
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 UniProt Comments for CD273    PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: plasma membrane; integral to membrane; endomembrane system

Biological Process: negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; T cell costimulation; positive regulation of T cell proliferation; immune response
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 Research Articles on CD273    1. conclude that PD-L2 protein is robustly expressed by the majority of primary mediastinal (thymic) large B-cell lymphomas
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD273 antibodyPathways associated with anti-CD273 antibody
 Reference Product  PubMed Publications
 PDCD1 antibody  >99 publications with CD273 and PDCD1
 CD4 antibody  >66 publications with CD273 and CD4
 CTLA4 antibody  >21 publications with CD273 and CTLA4
 CD40 antibody  >15 publications with CD273 and CD40
 BTLA antibody  >2 publications with CD273 and BTLA
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
Diseases associated with anti-CD273 antibodyOrgans/Tissues associated with anti-CD273 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >28 publications with CD273 and Inflammation
 Necrosis Antibodies  >16 publications with CD273 and Necrosis
 Carcinoma Antibodies  >13 publications with CD273 and Carcinoma
 Nervous System Diseases Antibodies  >12 publications with CD273 and Nervous System Diseases
 Lung Diseases Antibodies  >12 publications with CD273 and Lung Diseases
 Adenocarcinoma Antibodies  >8 publications with CD273 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >7 publications with CD273 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >5 publications with CD273 and Liver Neoplasms
 Kidney Diseases Antibodies  >4 publications with CD273 and Kidney Diseases
 Lung Neoplasms Antibodies  >4 publications with CD273 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >20 publications with CD273 and Lung
 Brain Antibodies  >9 publications with CD273 and Brain
 Vascular Antibodies  >8 publications with CD273 and Vascular
 Heart Antibodies  >7 publications with CD273 and Heart
 Placenta Antibodies  >4 publications with CD273 and Placenta
 Thymus Antibodies  >2 publications with CD273 and Thymus
 Uterus Antibodies  >2 publications with CD273 and Uterus
 Ganglia Antibodies  >1 publications with CD273 and Ganglia
 Testis Antibodies  >1 publications with CD273 and Testis
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