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anti-CD276 antibody :: anti-Mouse CD276 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2534023 anti-CD276 antibody
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 Product Name   

CD276, Monoclonal Antibody

★Popular Item★
 Also Known As   

LE/AF Purified Anti-Mouse CD276 (B7-H3) Antibody

 Product Gene Name   

anti-CD276 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605715
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MJ18
 Species Reactivity    Mouse
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 Form/Format    PBS pH 7.2, 0.09% NaN3, 0.2% BSA
 Concentration    1 mg/ml (lot specific)
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 Conjugation    LE/AF
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 Preparation and Storage    Keep as concentrated solution. Store at 4 degree C as an undiluted liquid. For extended storage aliquot contents and freeze at -20 degree C or lower. Avoid cycles of freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD276 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD276 antibody

   B7-H3 is a type I transmembrane protein belonging to the B7 family of co-stimulatory proteins. B7-H3 is mostly expressed on professional APCs including B cells, macrophages, and dendritic cells at low level. It is detected on various human and murine tumor cells, nasal and airway epithelial cells. Its expression on dendritic cells appears to be up-regulated by LPS. Initial studies have shown that B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. Mouse B7-H3 protein inhibited T cell activation and effector cytokine production. Thus, the immunological function of B7-H3 remains unclear. B7-H3 is involved in the suppression of Th1-mediated immune responses and plays an important role in the development of pathogenic Th2 cells in a murine asthma model. Monoclonal antibody against B7-H3 enhances T cell proliferation in vitro and leads to exacerbated EAE in vivo. It was reported recently that the Triggering Receptor Expressed on Myeloid cells (TREM)-like Transcript 2 (TLT-2, TREML2) is a receptor for B7-H3 in mice. It remains controversial. Further studies are needed to identify the receptor of B7-H3.
NCBI/Uniprot data below describe general gene information for CD276. It may not necessarily be applicable to this product.
 NCBI GI #    67188443
 NCBI GeneID    80381
 NCBI Accession #    NP_001019907.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024736.1 [Other Products]
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 UniProt Secondary Accession #    Q6P5Y4; Q6UXI2; Q8NBI8; Q8NC34; Q8NCB6; Q9BXR1 [Other Products]
 UniProt Related Accession #    Q5ZPR3 [Other Products]
 Molecular Weight    57,165 Da
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 NCBI Official Full Name    CD276 antigen isoform a
 NCBI Official Synonym Full Names    CD276 molecule
 NCBI Official Symbol    CD276 [Similar Products]
 NCBI Official Synonym Symbols   
B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
[Similar Products]
 NCBI Protein Information    CD276 antigen
 UniProt Protein Name    CD276 antigen
 UniProt Synonym Protein Names   
4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD_antigen: CD276
 Protein Family    CD276 antigen
 UniProt Gene Name    CD276 [Similar Products]
 UniProt Synonym Gene Names    B7H3; B7-H3 [Similar Products]
 UniProt Entry Name    CD276_HUMAN
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 NCBI Summary for CD276    The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for CD276    CD276: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q23-q24

Cellular Component: external side of plasma membrane; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: cell proliferation; immune response; negative regulation of inflammatory response; negative regulation of interferon-gamma biosynthetic process; negative regulation of interleukin-2 biosynthetic process; negative regulation of T cell proliferation; positive regulation of bone mineralization; positive regulation of interferon-gamma biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of T cell proliferation; regulation of immune response; T cell activation
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 Research Articles on CD276    1. found that the N-glycans of B7-H3 from Ca9-22 oral cancer cells contain the terminal alpha-galactose and are more diverse with higher fucosylation and better interaction with DC-SIGN and Langerin on immune cells than that from normal cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD276 antibodyPathways associated with anti-CD276 antibody
 Reference Product  PubMed Publications
 TREML2 antibody  >4 publications with CD276 and TREML2
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-CD276 antibodyOrgans/Tissues associated with anti-CD276 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >50 publications with CD276 and Carcinoma
 Neoplasm Metastasis Antibodies  >19 publications with CD276 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >17 publications with CD276 and Neoplasms, Experimental
 Liver Diseases Antibodies  >16 publications with CD276 and Liver Diseases
 Disease Models, Animal Antibodies  >16 publications with CD276 and Disease Models, Animal
 Liver Neoplasms Antibodies  >14 publications with CD276 and Liver Neoplasms
 Lung Diseases Antibodies  >14 publications with CD276 and Lung Diseases
 Necrosis Antibodies  >12 publications with CD276 and Necrosis
 Breast Neoplasms Antibodies  >11 publications with CD276 and Breast Neoplasms
 Lung Neoplasms Antibodies  >10 publications with CD276 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >117 publications with CD276 and Blood
 Liver Antibodies  >22 publications with CD276 and Liver
 Vascular Antibodies  >16 publications with CD276 and Vascular
 Lung Antibodies  >15 publications with CD276 and Lung
 Brain Antibodies  >12 publications with CD276 and Brain
 Bone Antibodies  >11 publications with CD276 and Bone
 Kidney Antibodies  >7 publications with CD276 and Kidney
 Prostate Antibodies  >7 publications with CD276 and Prostate
 Heart Antibodies  >6 publications with CD276 and Heart
 Skin Antibodies  >6 publications with CD276 and Skin
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