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anti-CD276 antibody :: anti-Human CD276 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS606057 anti-CD276 antibody
Unit / Price
0.2 mg  /  $645 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD276, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti - CD276 (4Ig-B7-H3, B7 Homolog 3, B7-H3, B7H3, CD276 Antigen, CD276 Molecule, Costimulatory Molecule)

 Product Synonym Names    CD276 (4Ig-B7-H3, B7 Homolog 3, B7-H3, B7H3, CD276 Antigen, CD276 Molecule, Costimulatory Molecule)
 Product Gene Name   

anti-CD276 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (73976622..74006859). Location: 15q23-q24
 OMIM    605715
 3D Structure    ModBase 3D Structure for Q5ZPR3
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10B1212
 Host    Mouse
Source: Human
 Species Reactivity    Human
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 Specificity    Recognizes human CD276.
 Purity/Purification    Purified by Protein G affinity chromatography.
 Form/Format    Affinity Purified
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
 Concentration    1mg/ml (lot specific)
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 Immunogen    Human CD276.
 Recommended Positive Control (IHC): Acetone fixed human tonsil.   
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CD276 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD276 antibody

   CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma.

Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
 Product Categories/Family for anti-CD276 antibody    Abs to CD Markers
 Applications Tested/Suitable for anti-CD276 antibody   

Immunohistochemistry, Flow Cytometry

 Application Notes for anti-CD276 antibody    Suitable for use in Flow Cytometry and Immunohistochemistry (frozen). Other applications not tested.
Dilution: Flow Cytometry: 1:10-1:100; 10ul labels 10e6 cells in 100ul
Immunohistochemistry (frozen): 1:100
Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for CD276. It may not necessarily be applicable to this product.
 NCBI GI #    67188443
 NCBI GeneID    80381
 NCBI Accession #    NP_001019907.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024736.1 [Other Products]
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 UniProt Primary Accession #    Q5ZPR3 [Other Products]
 UniProt Secondary Accession #    Q6P5Y4; Q6UXI2; Q8NBI8; Q8NC34; Q8NCB6; Q9BXR1 [Other Products]
 UniProt Related Accession #    Q5ZPR3 [Other Products]
 Molecular Weight    57,235 Da
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 NCBI Official Full Name    CD276 antigen isoform a
 NCBI Official Synonym Full Names    CD276 molecule
 NCBI Official Symbol    CD276 [Similar Products]
 NCBI Official Synonym Symbols   
B7H3; B7-H3; 4Ig-B7-H3
[Similar Products]
 NCBI Protein Information    CD276 antigen; B7 homolog 3; OTTHUMP00000174913; OTTHUMP00000174914; costimulatory molecule
 UniProt Protein Name    CD276 antigen
 UniProt Synonym Protein Names   
4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule
 Protein Family    CD276 antigen
 UniProt Gene Name    CD276 [Similar Products]
 UniProt Synonym Gene Names    B7H3 [Similar Products]
 UniProt Entry Name    CD276_HUMAN
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 NCBI Summary for CD276    Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM]
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 UniProt Comments for CD276    CD276: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q23-q24

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: cell proliferation; positive regulation of osteoblast differentiation; regulation of immune response; negative regulation of T cell proliferation; T cell activation; negative regulation of inflammatory response; negative regulation of interleukin-2 biosynthetic process; positive regulation of T cell proliferation; immune response; positive regulation of bone mineralization; positive regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma biosynthetic process
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Product References and Citations for anti-CD276 antibody

   • 1. Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2: 269-274,
• 2. Sun, X. et al. (2003) Mouse B7-H3 induces antitumor immunity. Gene Ther. 10: 1728-1734,
• 3. Ma, L. et al. (2007) Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy. J. Hepatol. 46: 98-106.As reported
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 Research Articles on CD276    1. B7-H3 appears to be a useful blood marker for predicting tumor progression in gastric cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD276 antibodyDiseases associated with anti-CD276 antibody
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >19 publications with CD276 and Carcinoma
 Necrosis Antibodies  >8 publications with CD276 and Necrosis
 Liver Neoplasms Antibodies  >6 publications with CD276 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with CD276 and Neoplasm Metastasis
 Inflammation Antibodies  >5 publications with CD276 and Inflammation
 Lung Neoplasms Antibodies  >4 publications with CD276 and Lung Neoplasms
 Liver Diseases Antibodies  >4 publications with CD276 and Liver Diseases
 Stomach Neoplasms Antibodies  >3 publications with CD276 and Stomach Neoplasms
 Breast Neoplasms Antibodies  >2 publications with CD276 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with CD276 and Pancreatic Neoplasms
Organs/Tissues associated with anti-CD276 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with CD276 and Blood
 Lung Antibodies  >7 publications with CD276 and Lung
 Liver Antibodies  >7 publications with CD276 and Liver
 Vascular Antibodies  >7 publications with CD276 and Vascular
 Prostate Antibodies  >5 publications with CD276 and Prostate
 Brain Antibodies  >5 publications with CD276 and Brain
 Kidney Antibodies  >4 publications with CD276 and Kidney
 Bone Antibodies  >4 publications with CD276 and Bone
 Stomach Antibodies  >3 publications with CD276 and Stomach
 Muscle Antibodies  >3 publications with CD276 and Muscle
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