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anti-CD279 antibody :: Mouse CD279 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS217320
Unit / Price
0.2 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD279, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD279

 Product Gene Name   

anti-CD279 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109100
 3D Structure    ModBase 3D Structure for Q15116
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MIH4
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Human CD279 - transfected L cells.
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD279 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD279 antibody

   Mouse anti Human CD279 antibody, clone MIH4 detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
 Applications Tested/Suitable for anti-CD279 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS)

 Application Notes for anti-CD279 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/200
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 Testing Data of anti-CD279 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD279:A488 (MBS217320A488)
anti-CD279 antibody Testing Data image
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 Testing Data of anti-CD279 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD279:RPE (MBS217325)
anti-CD279 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD279. It may not necessarily be applicable to this product.
 NCBI GI #    167857792
 NCBI GeneID    5133
 NCBI Accession #    NP_005009.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005018.2 [Other Products]
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 UniProt Primary Accession #    Q15116 [Other Products]
 UniProt Secondary Accession #    O00517; Q8IX89 [Other Products]
 UniProt Related Accession #    Q15116 [Other Products]
 Molecular Weight    31,647 Da
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 NCBI Official Full Name    programmed cell death protein 1
 NCBI Official Synonym Full Names    programmed cell death 1
 NCBI Official Symbol    PDCD1 [Similar Products]
 NCBI Official Synonym Symbols   
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
[Similar Products]
 NCBI Protein Information    programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
 UniProt Protein Name    Programmed cell death protein 1
 UniProt Synonym Protein Names   
CD_antigen: CD279
 UniProt Gene Name    PDCD1 [Similar Products]
 UniProt Synonym Gene Names    PD1; Protein PD-1; hPD-1 [Similar Products]
 UniProt Entry Name    PDCD1_HUMAN
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 NCBI Summary for CD279    This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD279    PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; signal transducer activity

Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response

Disease: Systemic Lupus Erythematosus
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 Research Articles on CD279    1. These data strongly support testing of PD-1-blocking agents in combination with standard-of-care chemoradiotherapy for papillomavirus (HPV)-related oropharyngeal cancer .
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD279 antibodyPathways associated with anti-CD279 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >418 publications with CD279 and CD4
 CD274 antibody  >336 publications with CD279 and CD274
 PDCD1LG2 antibody  >99 publications with CD279 and PDCD1LG2
 PTPN6 antibody  >7 publications with CD279 and PTPN6
 PTPN11 antibody  >7 publications with CD279 and PTPN11
 HLA-DR4 antibody  >1 publications with CD279 and HLA-DR4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-CD279 antibodyOrgans/Tissues associated with anti-CD279 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >147 publications with CD279 and Liver Diseases
 Inflammation Antibodies  >115 publications with CD279 and Inflammation
 Melanoma Antibodies  >79 publications with CD279 and Melanoma
 Necrosis Antibodies  >75 publications with CD279 and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >72 publications with CD279 and Lupus Erythematosus, Systemic
 Lung Diseases Antibodies  >58 publications with CD279 and Lung Diseases
 Lung Neoplasms Antibodies  >38 publications with CD279 and Lung Neoplasms
 Adenocarcinoma Antibodies  >35 publications with CD279 and Adenocarcinoma
 Kidney Diseases Antibodies  >28 publications with CD279 and Kidney Diseases
 Liver Neoplasms Antibodies  >26 publications with CD279 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >945 publications with CD279 and Blood
 Kidney Antibodies  >36 publications with CD279 and Kidney
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