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anti-CD28 antibody :: anti-Rat CD28 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2534380 anti-CD28 antibody
Unit / Price
0.05 mg  /  $145 +1 FREE 8GB USB
0.5 mg  /  $395 +1 FREE 8GB USB
1 mg  /  $575 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD28, Monoclonal Antibody

 Also Known As   

LE/AF Purified Anti-Mouse CD28 Antibody

 Product Gene Name   

anti-CD28 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    JJ319
 Species Reactivity    Rat
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 Form/Format    PBS pH 7.2, 0.09% NaN3, 0.2% BSA
 Concentration    1 mg/ml (lot specific)
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 Conjugation    LE/AF
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 Preparation and Storage    Keep as concentrated solution. Store at 4 degree C as an undiluted liquid. For extended storage aliquot contents and freeze at -20 degree C or lower. Avoid cycles of freezing and thawing.
 Other Notes    Small volumes of anti-CD28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD28 antibody

   CD28 is a 44 kD glycoprotein also known as Tp44 or T44. It is a member of the immunoglobulin superfamily and is expressed on thymocytes, alpha/betaTCR+ T cells, most gamma/deltaTCR+ T cells, and an NK cell subset. During interaction with CD80 (B7-1) or CD86 (B7-2), CD28 acts as the second signal for T cell stimulation.
NCBI/Uniprot data below describe general gene information for CD28. It may not necessarily be applicable to this product.
 NCBI GI #    192485
 NCBI GeneID    12487
 NCBI Accession #    AAA37396.1 [Other Products]
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 UniProt Secondary Accession #    Q6GSH7 [Other Products]
 UniProt Related Accession #    P31041 [Other Products]
 Molecular Weight    25,243 Da
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 NCBI Official Full Name    CD28, partial
 NCBI Official Synonym Full Names    CD28 antigen
 NCBI Official Symbol    Cd28 [Similar Products]
 NCBI Protein Information    T-cell-specific surface glycoprotein CD28
 UniProt Protein Name    T-cell-specific surface glycoprotein CD28
 UniProt Synonym Protein Names   
CD_antigen: CD28
 Protein Family    T-cell-specific surface glycoprotein
 UniProt Gene Name    Cd28 [Similar Products]
 UniProt Entry Name    CD28_MOUSE
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 UniProt Comments for CD28    CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: external side of plasma membrane; immunological synapse; integral to membrane; lipid raft; membrane; plasma membrane

Molecular Function: protease binding; protein homodimerization activity; protein kinase binding; SH3/SH2 adaptor activity

Biological Process: immune response; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of inflammatory response to antigenic stimulus; positive regulation of interleukin-2 biosynthetic process; positive regulation of isotype switching to IgG isotypes; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of regulatory T cell differentiation; regulatory T cell differentiation; T cell activation; T cell costimulation; T cell receptor signaling pathway
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 Research Articles on CD28    1. results suggest a key role for CD28 costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine receptors such as CCR6 that are required for tissue homing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD28 antibodyPathways associated with anti-CD28 antibody
 Reference Product  PubMed Publications
 Cd80 antibody  >1857 publications with CD28 and Cd80
 Cd86 antibody  >1117 publications with CD28 and Cd86
 Lck antibody  >174 publications with CD28 and Lck
 Vav1 antibody  >61 publications with CD28 and Vav1
 Grb2 antibody  >30 publications with CD28 and Grb2
 Grap2 antibody  >7 publications with CD28 and Grap2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-CD28 antibodyOrgans/Tissues associated with anti-CD28 antibody
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >1294 publications with CD28 and Autoimmune Diseases
 Necrosis Antibodies  >888 publications with CD28 and Necrosis
 Inflammation Antibodies  >881 publications with CD28 and Inflammation
 HIV Infections Antibodies  >465 publications with CD28 and HIV Infections
 Arthritis, Rheumatoid Antibodies  >381 publications with CD28 and Arthritis, Rheumatoid
 Lung Diseases Antibodies  >337 publications with CD28 and Lung Diseases
 Vascular Diseases Antibodies  >303 publications with CD28 and Vascular Diseases
 Carcinoma Antibodies  >254 publications with CD28 and Carcinoma
 Liver Diseases Antibodies  >174 publications with CD28 and Liver Diseases
 Kidney Diseases Antibodies  >151 publications with CD28 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >583 publications with CD28 and Spleen
 Bone Antibodies  >441 publications with CD28 and Bone
 Bone Marrow Antibodies  >390 publications with CD28 and Bone Marrow
 Lung Antibodies  >374 publications with CD28 and Lung
 Thymus Antibodies  >354 publications with CD28 and Thymus
 Skin Antibodies  >332 publications with CD28 and Skin
 Joint Antibodies  >163 publications with CD28 and Joint
 Embryonic Tissue Antibodies  >56 publications with CD28 and Embryonic Tissue
 Mammary Gland Antibodies  >3 publications with CD28 and Mammary Gland
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