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anti-CD28 antibody :: Hamster anti-Murine CD28 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531972 anti-CD28 antibody
Unit / Price
0.1 mg  /  $315 +1 FREE 8GB USB
0.2 mg  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD28, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD28 antibody (PE)

 Product Synonym Names    Monoclonal CD28; Anti-CD28; CD 28; CD28; CD-28
 Product Gene Name   

anti-CD28 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P31041
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    37.51
 Host    Hamster
 Species Reactivity    Murine
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 Form/Format    Supplied as a liquid in PBS, with NaN3 added as preservative.
 Concentration    0.1 mg/ml (lot specific)
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 Biological Significance    CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for B7.1 (CD80) and B7.2 (CD86). When activated by Toll-like receptor ligands, the B7.1 expression is upregulated in antigen presenting cells (APCs). The B7.2 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    PE
 Immunogen    CD28 antibody (PE) was raised in hamster using CD28 costimulatory receptor as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD28 antibody

   Hamster monoclonal CD28 antibody (PE)
 Product Categories/Family for anti-CD28 antibody    Immunology; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD28 antibody   

Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for CD28. It may not necessarily be applicable to this product.
 NCBI GI #    192485
 NCBI GeneID    12487
 NCBI Accession #    AAA37396.1 [Other Products]
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 UniProt Primary Accession #    P31041 [Other Products]
 UniProt Secondary Accession #    Q6GSH7 [Other Products]
 UniProt Related Accession #    P31041 [Other Products]
 Molecular Weight    25,243 Da
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 NCBI Official Full Name    CD28, partial
 NCBI Official Synonym Full Names    CD28 antigen
 NCBI Official Symbol    Cd28 [Similar Products]
 NCBI Protein Information    T-cell-specific surface glycoprotein CD28
 UniProt Protein Name    T-cell-specific surface glycoprotein CD28
 UniProt Synonym Protein Names   
CD_antigen: CD28
 Protein Family    T-cell-specific surface glycoprotein
 UniProt Gene Name    Cd28 [Similar Products]
 UniProt Entry Name    CD28_MOUSE
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 UniProt Comments for CD28    CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: membrane; integral to membrane; plasma membrane; immunological synapse; lipid raft; external side of plasma membrane

Molecular Function: protein homodimerization activity; protease binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; T cell activation; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of inflammatory response to antigenic stimulus; positive regulation of protein kinase B signaling cascade; T cell costimulation; positive regulation of T cell proliferation; immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulatory T cell differentiation
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 Research Articles on CD28    1. Data show that calcium-promoted Ras inactivator (CAPRI) C2AB domains are required for CD28 antigen inhibition of adhesion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD28 antibodyPathways associated with anti-CD28 antibody
 Reference Product  PubMed Publications
 Cd80 antibody  >1824 publications with CD28 and Cd80
 Cd86 antibody  >1090 publications with CD28 and Cd86
 Lck antibody  >170 publications with CD28 and Lck
 Vav1 antibody  >59 publications with CD28 and Vav1
 Grb2 antibody  >29 publications with CD28 and Grb2
 Grap2 antibody  >6 publications with CD28 and Grap2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-CD28 antibodyOrgans/Tissues associated with anti-CD28 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2421 publications with CD28 and Immune System Diseases
 Autoimmune Diseases Antibodies  >1261 publications with CD28 and Autoimmune Diseases
 Necrosis Antibodies  >862 publications with CD28 and Necrosis
 Inflammation Antibodies  >835 publications with CD28 and Inflammation
 Death Antibodies  >698 publications with CD28 and Death
 HIV Infections Antibodies  >460 publications with CD28 and HIV Infections
 Arthritis, Rheumatoid Antibodies  >365 publications with CD28 and Arthritis, Rheumatoid
 Lung Diseases Antibodies  >317 publications with CD28 and Lung Diseases
 Vascular Diseases Antibodies  >292 publications with CD28 and Vascular Diseases
 Lymphoma Antibodies  >287 publications with CD28 and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >568 publications with CD28 and Spleen
 Bone Antibodies  >429 publications with CD28 and Bone
 Bone Marrow Antibodies  >382 publications with CD28 and Bone Marrow
 Lung Antibodies  >352 publications with CD28 and Lung
 Thymus Antibodies  >347 publications with CD28 and Thymus
 Skin Antibodies  >320 publications with CD28 and Skin
 Joint Antibodies  >154 publications with CD28 and Joint
 Embryonic Tissue Antibodies  >56 publications with CD28 and Embryonic Tissue
 Mammary Gland Antibodies  >3 publications with CD28 and Mammary Gland
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