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anti-CD3E antibody :: anti-Mouse CD3 Epsilon Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311895 anti-CD3E antibody
Unit / Price
0.5 mg  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD3 Epsilon (CD3E), Monoclonal Antibody

 Also Known As   

MAb to Mouse CD3 Epsilon

 Product Synonym Names    Monoclonal Antibody to Mouse CD3 epsilon
 Product Gene Name   

anti-CD3E antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (118175295..118186890). Location: 11q23
 OMIM    186830
 3D Structure    ModBase 3D Structure for P07766
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 Clonality    Monoclonal
 Isotype    IgG (Hamster)
 Clone Number    500-A2
 Host    Host: Syrian Hamster
Source: Tissue Culture
 Species Reactivity    Mouse
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 Specificity    CD3 Epsilon
Anti-Mouse CD3 epsilon recognizes the (Mr 25kD) epsilon chain of the CD3 T-cell receptor complex expressed on mouse T-cells. The CD3 epsilon is present on thymocytes, CD8+ and CD4+ positive cells expressed low level of CD3 epsilon while cel
 Purity/Purification    Protein G chromatography
 Form/Format    Purified, Liquid
 Concentration    0.5mg/ml (OD280nm) (lot specific)
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 Immunogen    C6VL-BS cell lysate
 Affinity Constant    Not determined.
 Buffer    0.01M PBS, pH 7.2 containing 1% BSA
 Preservative    0.09% Sodium Azide
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short-term (up to 6 months) store at 2 to 8 degree C. Long-term, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD3E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD3E antibody    Monoclonal Antibodies to Non-Human CDs
 Application Notes for anti-CD3E antibody    Anti-CD3 epsilon antibody can be used for flow cytometric analysis, immunofluorescence and immunohistochemical staining of acetone fixed fresh frozen tissue sections. We recommend using 1ug to stain 1.0 x 106 cells in flow cytometric applications. Each la
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NCBI/Uniprot data below describe general gene information for CD3E. It may not necessarily be applicable to this product.
 NCBI GI #    4502671
 NCBI GeneID    916
 NCBI Accession #    NP_000724.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000733.3 [Other Products]
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 UniProt Primary Accession #    P07766 [Other Products]
 UniProt Secondary Accession #    A8K997 [Other Products]
 UniProt Related Accession #    P07766 [Other Products]
 Molecular Weight    23,147 Da [Similar Products]
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 NCBI Official Full Name    T-cell surface glycoprotein CD3 epsilon chain
 NCBI Official Synonym Full Names    CD3e molecule, epsilon (CD3-TCR complex)
 NCBI Official Symbol    CD3E [Similar Products]
 NCBI Official Synonym Symbols   
T3E; TCRE; FLJ18683
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; OTTHUMP00000234559; OTTHUMP00000234560; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
 UniProt Protein Name    T-cell surface glycoprotein CD3 epsilon chain
 UniProt Synonym Protein Names   
T-cell surface antigen T3/Leu-4 epsilon chain
 Protein Family    T-cell surface glycoprotein
 UniProt Gene Name    CD3E [Similar Products]
 UniProt Synonym Gene Names    T3E [Similar Products]
 UniProt Entry Name    CD3E_HUMAN
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 NCBI Summary for CD3E    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq]
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 UniProt Comments for CD3E    Function: The CD3 complex mediates signal transduction.

Subunit structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. Ref.13 Ref.14

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Contains 1 Ig-like (immunoglobulin-like) domain.Contains 1 ITAM domain.
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Product References and Citations for anti-CD3E antibody

   • Havran, W.M. et al., (1987), "Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes", Nature, 330, 170-173
• Allison, J.W. et al., (1988), "Expression and function of CD3 on murine thymocytes." The T-cell
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 Research Articles on CD3E    1. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD3E antibodyPathways associated with anti-CD3E antibody
 Reference Product  PubMed Publications
 ZAP70 antibody  >13 publications with CD3E and ZAP70
 LCK antibody  >13 publications with CD3E and LCK
 CD3D antibody  >9 publications with CD3E and CD3D
 CD3G antibody  >6 publications with CD3E and CD3G
 SYK antibody  >3 publications with CD3E and SYK
 CD79B antibody  >3 publications with CD3E and CD79B
 NCK2 antibody  >1 publications with CD3E and NCK2
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-CD3E antibodyOrgans/Tissues associated with anti-CD3E antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with CD3E and Inflammation
 Immunologic Deficiency Syndromes Antibodies  >10 publications with CD3E and Immunologic Deficiency Syndromes
 Carcinoma Antibodies  >5 publications with CD3E and Carcinoma
 Liver Diseases Antibodies  >4 publications with CD3E and Liver Diseases
 Skin Neoplasms Antibodies  >4 publications with CD3E and Skin Neoplasms
 Drug Toxicity Antibodies  >3 publications with CD3E and Drug Toxicity
 Fibrosis Antibodies  >2 publications with CD3E and Fibrosis
 Gastritis Antibodies  >2 publications with CD3E and Gastritis
 Lung Neoplasms Antibodies  >2 publications with CD3E and Lung Neoplasms
 Kidney Diseases Antibodies  >2 publications with CD3E and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >155 publications with CD3E and Blood
 Thymus Antibodies  >40 publications with CD3E and Thymus
 Spleen Antibodies  >28 publications with CD3E and Spleen
 Lymph Node Antibodies  >12 publications with CD3E and Lymph Node
 Liver Antibodies  >10 publications with CD3E and Liver
 Intestine Antibodies  >8 publications with CD3E and Intestine
 Lung Antibodies  >7 publications with CD3E and Lung
 Brain Antibodies  >4 publications with CD3E and Brain
 Heart Antibodies  >3 publications with CD3E and Heart
 Eye Antibodies  >3 publications with CD3E and Eye
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