NP_000064.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,469 Da
NCBI Official Full Name
T-cell surface glycoprotein CD3 gamma chain
NCBI Official Synonym Full Names
CD3g molecule, gamma (CD3-TCR complex)
NCBI Protein Information
T-cell surface glycoprotein CD3 gamma chain; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain
UniProt Protein Name
T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names
T-cell receptor T3 gamma chain; CD_antigen: CD3g
UniProt Synonym Gene Names
UniProt Entry Name
CD3G_HUMAN
NCBI Summary for CD3
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for CD3
CD3G: The CD3 complex mediates signal transduction.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; alpha-beta T cell receptor complex
Molecular Function: receptor signaling complex scaffold activity; transmembrane receptor activity; protein heterodimerization activity; T cell receptor binding
Biological Process: regulation of immune response; protein transport; cell surface receptor linked signal transduction; T cell activation; T cell costimulation; establishment and/or maintenance of cell polarity; innate immune response; protein complex assembly; T cell receptor signaling pathway
Disease: Immunodeficiency 17
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Products associated with anti-CD3 antibody
Pathways associated with anti-CD3 antibody
Diseases associated with anti-CD3 antibody
Organs/Tissues associated with anti-CD3 antibody
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