NP_031674.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
21,393 Da
NCBI Official Full Name
T-cell surface glycoprotein CD3 epsilon chain
NCBI Official Synonym Full Names
CD3 antigen, epsilon polypeptide
NCBI Protein Information
T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain
UniProt Protein Name
T-cell surface glycoprotein CD3 epsilon chain
UniProt Synonym Protein Names
T-cell surface antigen T3/Leu-4 epsilon chain; CD_antigen: CD3e
UniProt Entry Name
CD3E_MOUSE
UniProt Comments for CD3
CD3E: a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain.
Protein type: Receptor, misc.; Membrane protein, integral
Cellular Component: T cell receptor complex; membrane; integral to membrane; plasma membrane; immunological synapse; alpha-beta T cell receptor complex; intercellular junction; external side of plasma membrane
Molecular Function: signal transducer activity; protein binding; transmembrane receptor activity; protein heterodimerization activity; SH3 domain binding
Biological Process: positive regulation of interleukin-2 biosynthetic process; lymphocyte activation; positive regulation of calcium-mediated signaling; T cell receptor signaling pathway; negative thymic T cell selection; positive regulation of interleukin-4 production; positive regulation of interferon-gamma production; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; negative regulation of smoothened signaling pathway; T cell costimulation; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell activation; positive regulation of T cell anergy; response to nutrient
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Pathways associated with anti-CD3 antibody
Diseases associated with anti-CD3 antibody
Organs/Tissues associated with anti-CD3 antibody
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