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anti-TNFRSF8 antibody :: anti-Mouse CD30 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673313 anti-TNFRSF8 antibody
Unit / Price
0.5 mg  /  $260 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD30 (TNFRSF8), Monoclonal Antibody

 Also Known As   

Hamster Anti-Mouse CD30-UNLB

 Product Synonym Names    Hamster Anti-Mouse CD30 - Purified, Unlabeled Antibody; Hamster Anti-Mouse CD30
 Product Gene Name   

anti-TNFRSF8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (12123434..12204264). Location: 1p36
 OMIM    153243
 3D Structure    ModBase 3D Structure for P28908
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 Clonality    Monoclonal
 Isotype    Armenian Hamster IgG kappa
 Clone Number    2SH12-5F (also known as mCD30.1)
 Host    Armenian Hamster
 Species Reactivity    Mouse
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 Specificity    Murine CD30, Mr 52 kDa (core peptide)
CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins.^1,2 Murine CD30 is expressed predominantly in the thymus, and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A.^1 In anti-CD3 epsilon -activated spleen cells, CD30 is expressed primarily on the surface of CD8^+ T cells with peak expression on days 4 and 5. Stimulation of CD30^+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN- gamma production. ^1 While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.
 Form/Format    Purified (UNLB) Antibody
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 Immunogen    Recombinant mouse CD30 extracellular domain-mouse IgG1 fusion protein
 Characterization    To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL or 0.2 mg in 2.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-TNFRSF8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TNFRSF8 antibody   

Flow Cytometry

 Application Notes for anti-TNFRSF8 antibody    Research Application(s): In vitro functional studies

Flow Cytometry Suggested Dilution: <= 3 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for TNFRSF8. It may not necessarily be applicable to this product.
 NCBI GI #    180096
 NCBI GeneID    943
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 UniProt Primary Accession #    P28908 [Other Products]
 UniProt Secondary Accession #    Q6P4D9; B1AN79 [Other Products]
 UniProt Related Accession #    P28908; Q6GMU3; Q9HCX5 [Other Products]
 Molecular Weight    63,747 Da [Similar Products]
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 NCBI Official Full Name    CD30 antigen
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 8
 NCBI Official Symbol    TNFRSF8 [Similar Products]
 NCBI Official Synonym Symbols   
CD30; Ki-1; D1S166E
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 8; CD30 antigen; Ki-1 antigen; CD30L receptor; OTTHUMP00000001783; OTTHUMP00000221481; cytokine receptor CD30; lymphocyte activation antigen CD30
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 8
 UniProt Synonym Protein Names   
CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30
 Protein Family    CD302 antigen
 UniProt Gene Name    TNFRSF8 [Similar Products]
 UniProt Synonym Gene Names    CD30; D1S166E [Similar Products]
 UniProt Entry Name    TNR8_HUMAN
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 NCBI Summary for TNFRSF8    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
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 UniProt Comments for TNFRSF8    Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Subunit structure: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein. Isoform Short: Cytoplasm.

Post-translational modification: Phosphorylated on serine and tyrosine residues. Ref.12

Miscellaneous: Most specific Hodgkin disease associated antigen.

Sequence similarities: Contains 6 TNFR-Cys repeats.
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Product References and Citations for anti-TNFRSF8 antibody

   1. Bowen, M.A., R.K. Lee, G. Miragliotta, S.Y. Nam, and E.R. Podack. 1996. J. Immunol. 156:442.
2. Falini, B., et al. 1995. Blood 85:1.
3. Shanebeck, K. D., et al. 1995. Eur. J. Immunol. 25:2147.
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 Research Articles on TNFRSF8    1. The data provide evidence that sCD30 can be used as a marker for diagnosing Epstein-Barr virus-associated lymphoproliferative diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF8 antibodyPathways associated with anti-TNFRSF8 antibody
 Reference Product  PubMed Publications
 TNFSF8 antibody  >1 publications with TNFRSF8 and TNFSF8
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-TNFRSF8 antibodyOrgans/Tissues associated with anti-TNFRSF8 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with TNFRSF8 and Neoplasms
 Inflammation Antibodies  >2 publications with TNFRSF8 and Inflammation
 Arthritis, Rheumatoid Antibodies  >1 publications with TNFRSF8 and Arthritis, Rheumatoid
 Dermatitis, Atopic Antibodies  >1 publications with TNFRSF8 and Dermatitis, Atopic
 Drug Toxicity Antibodies  >1 publications with TNFRSF8 and Drug Toxicity
 Carcinoma Antibodies  >1 publications with TNFRSF8 and Carcinoma
 Respiratory Hypersensitivity Antibodies  >1 publications with TNFRSF8 and Respiratory Hypersensitivity
 Sepsis Antibodies  >1 publications with TNFRSF8 and Sepsis
 Recurrence Antibodies  >1 publications with TNFRSF8 and Recurrence
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with TNFRSF8 and Blood
 Mixed Antibodies  >1 publications with TNFRSF8 and Mixed
 Lung Antibodies  >1 publications with TNFRSF8 and Lung
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