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anti-CD30 antibody :: Mouse anti-Human CD30 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245116
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD30, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone MEM-268] (IgG) to Human CD30

 Product Synonym Names    Anti-CD30 Antibody (clone MEM-268) IHC-plus; TNFRSF8; CD30L receptor; CD30; Cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; CD30 antigen; Human CD30
 Product Gene Name   

anti-CD30 antibody

[Similar Products]
 Product Synonym Gene Name    TNFRSF8 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153243
 3D Structure    ModBase 3D Structure for P28908
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    MEM-268
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
 Purity/Purification    Protein A Purified
 Form/Format    PBS, 15 mM sodium azide, approx., pH 7.4.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Cells.
 Immunogen    CD30 antibody was raised against cells.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-CD30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD30 antibody    Family: TNF Receptor
 Applications Tested/Suitable for anti-CD30 antibody   

Immunohistochemistry (IHC - Paraffin), Flow Cytometry (FC/FACS)

 Application Notes for anti-CD30 antibody    Flo, IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CD30 antibody    Anti-TNFRSF8 / CD30 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD30 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD30. It may not necessarily be applicable to this product.
 NCBI GI #    68348711
 NCBI GeneID    943
 NCBI Accession #    NP_001234.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243.3 [Other Products]
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 UniProt Primary Accession #    P28908 [Other Products]
 UniProt Secondary Accession #    Q6P4D9; B1AN79; B9EGD9; D3YTD8 [Other Products]
 UniProt Related Accession #    P28908 [Other Products]
 Molecular Weight    50,935 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 8 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 8
 NCBI Official Symbol    TNFRSF8 [Similar Products]
 NCBI Official Synonym Symbols   
CD30; Ki-1; D1S166E
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 8
 UniProt Synonym Protein Names   
CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
 Protein Family    CD302 antigen
 UniProt Gene Name    TNFRSF8 [Similar Products]
 UniProt Synonym Gene Names    CD30; D1S166E [Similar Products]
 UniProt Entry Name    TNR8_HUMAN
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 NCBI Summary for CD30    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD30    TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: negative regulation of cell proliferation; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction
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 Research Articles on CD30    1. a substantial subset of patients with T-ALL have lymphoblasts that express surface CD30. CD30 expression by T-lymphoblasts also appears to be up-regulated in patients who are treated with high-dose chemotherapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD30 antibodyPathways associated with anti-CD30 antibody
 Reference Product  PubMed Publications
 ALK antibody  >184 publications with CD30 and ALK
 TNFSF8 antibody  >94 publications with CD30 and TNFSF8
 TRAF2 antibody  >36 publications with CD30 and TRAF2
 TRAF1 antibody  >27 publications with CD30 and TRAF1
 TRAF3 antibody  >13 publications with CD30 and TRAF3
 JUNB antibody  >13 publications with CD30 and JUNB
 TRAF5 antibody  >10 publications with CD30 and TRAF5
 CCL4 antibody  >3 publications with CD30 and CCL4
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-CD30 antibodyOrgans/Tissues associated with anti-CD30 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1826 publications with CD30 and Immune System Diseases
 Hodgkin Disease Antibodies  >572 publications with CD30 and Hodgkin Disease
 Skin Neoplasms Antibodies  >371 publications with CD30 and Skin Neoplasms
 Necrosis Antibodies  >311 publications with CD30 and Necrosis
 Carcinoma Antibodies  >130 publications with CD30 and Carcinoma
 Neoplasms, Experimental Antibodies  >109 publications with CD30 and Neoplasms, Experimental
 Inflammation Antibodies  >91 publications with CD30 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >63 publications with CD30 and Cell Transformation, Neoplastic
 Fever Antibodies  >63 publications with CD30 and Fever
 Hyperplasia Antibodies  >56 publications with CD30 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1159 publications with CD30 and Blood
 Lymph Node Antibodies  >351 publications with CD30 and Lymph Node
 Lung Antibodies  >74 publications with CD30 and Lung
 Intestine Antibodies  >28 publications with CD30 and Intestine
 Testis Antibodies  >23 publications with CD30 and Testis
 Embryonic Tissue Antibodies  >23 publications with CD30 and Embryonic Tissue
 Uterus Antibodies  >7 publications with CD30 and Uterus
 Salivary Gland Antibodies  >2 publications with CD30 and Salivary Gland
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